National Toxicology Program

Decalin (TR-513)

The Subcommittee accepted unanimously (10 yes, 0 no) the conclusions as written, clear evidence of carcinogenic activity of decalin in male rats, no evidence of carcinogenic activity in female rats and in male mice, and equivocal evidence of carcinogenic activity in female mice.

Dipropylene Glycol (TR-511)

The Subcommittee accepted (9 yes votes, 1 abstention) the conclusions as written, no evidence of carcinogenic activity of dipropylene glycol in male and female rats and no evidence of carcinogenic activity in male and female mice.

Elmiron® (TR-512)

The Subcommittee accepted unanimously (10 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of elmiron in male and female rats and some evidence of carcinogenic activity in male and female mice. The Subcommittee recommended that the hepatocellular neoplasms in female mice be clarified as being predominately adenomas.

trans-Cinnamaldehyde (TR-514)

The Subcommittee accepted unanimously (10 yes, 0 no) the conclusions as written, no evidence of carcinogenic activity of trans-cinnamaldehyde in male and female rats and in male and female mice.

Urethane + Ethanol (TR-510)

The Subcommittee accepted unanimously (10 yes, 0 no) the conclusion, clear evidence of carcinogenic activity of urethane in male and female mice. The Subcommittee recommended that skin be added to clear evidence in male mice and that the heart be removed from the list of hemangiosarcomas identified in female mice. The Subcommittee recommended that the occurrences of hemangiosarcoma of the spleen in males and of the uterus and skin in females be changed from were also considered to be exposure related to may have been exposure related.

The Subcommittee concluded unanimously that the study design was inadequate to determine the carcinogenic activity of ethanol in male and female mice.

The Subcommittee accepted unanimously the conclusion, weak evidence of an interaction of ethanol on the carcinogenicity of urethane in mice.

Trimethylolpropane triacrylate (TMPTA) and Pentaerythritol triacrylate (PETA) Tg.AC Mouse Studies

The abstracts for the studies of Trimethylolpropane Triacrylate (TMPTA) and Pentaerythritol Triacrylate (PETA) in the Tg.AC mouse model have been removed from this page. The NTP decided to withdraw the "consideration of carcinogenic activity" of the results of these studies by the NTP Board of Scientific Counselors Technical Reports Review Subcommittee at the September 6, 2002 meeting. The NTP does not consider the tumorigenic responses in the Tg.AC mouse model to be comparable to those observed in the 2-year rodent studies and therefore these results would not be judged as an adequate study of the carcinogenic activity. The NTP will re-evaluate the data from these studies and prepare new reports on TMPTA and PETA as part of the NTP Toxicity Report Series. Please destroy any copies of draft NTP Technical Reports 516 and 517.

The data for the Pentaerythritol Triacrylate and Trimethylolpropane Triacrylate Tg.AC mouse 26-week topical exposure studies have been moved to "Pathology Data for Short-Term (studies less than 1 year in length) Toxicity Studies" (About Short Term).