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Vitamin D and Cancer: Current Dilemas/Future Needs
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Meeting Date
May 7-8, 2007
Meeting Location
Lister Hill Auditorium
First Floor, Lister Hill Center, Building 38A
National Institutes of Health
8600 Rockville Pike (at Center Drive)
Bethesda, MD 20894
Meeting Objectives
- To evaluate the scientific evidence related to vitamin D and cancer risk.
- Identify gaps in knowledge and determine the research needed to make science-based recommendations for vitamin D intake/exposure for cancer prevention.
- The conference topics covered included the relative importance of sunlight exposure and diet as sources of vitamin D; the epidemiological evidence of the nature and strength of the association between vitamin D and cancer risk; how nutrigenetics has advanced our understanding of the relationship between vitamin D and cancer risk; discussion of new information about the role of genes and cross-talk among genes that may influence the response to vitamin D; the interrelationship between vitamin D and other dietary components that may modify the response; and information provided by preclinical models about the relationship between vitamin D and cancer.
Meeting Materials
Presentations
| Name |
Presentation |
Gary Schwartz, PhD, MPH, PhD
Associate Professor, Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine |
Setting the Stage: What are the Critical Factors for Evaluating Sunlight and Dietary Vitamin D and Cancer Risk?
Abstract (pdf, 12kb) |
Ed Giovannucci, MD, ScD
Professor, Nutrition and Epidemiology, Harvard School of Public Health |
What are the Strengths and Limitations of Current Epidemiologic Studies Investigating Vitamin D Intake and Status as a Modifier of Breast Cancer Risk?
Abstract (pdf, 8kb) |
Thomas Rohan, MD, PhD
Chairman, Epidemiology and Population Health, Albert Einstein School of Medicine |
What are the Strengths and Limitationsof Current Epidemiologic Studies of Vitamin D Intake and Status as a Modifier of Breast Cancer Risk? (ppt, 120kb)
Abstract (pdf, 8kb) |
Margaret Tucker, MD
Director, Human Genetics Program, Genetic Epidemiology Branch, DCEG, National Cancer Institute |
What are the Strengths and Limitations of Current Assessment Tools for Sunlight Exposure in Populations? (ppt, 1.77mb) |
Bruce Hollis, PhD
Professor, Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina |
What are the Strengths and Limitations of Current Assessment Tools for Vitamin D Status in Populations? (ppt, 2.74mb)
Abstract (pdf, 9kb) |
Cedric Garland, DrPH
Professor, Department of Family and Preventive Medicine, University of California San Diego School of Medicine |
What is the Dose Response Relationship Between Vitamin D Statusand Cancer? (ppt, 1.35mb)
Abstract (pdf, 12kb) |
Nicholas Rukin, MBChB
Urology Research Fellow, Department of Urological Surgery, Keele University Medical School |
What are the Frequency, Distribution and Functional Effects of Vitamin D Receptor Polymorphisms as Related to Cancer Risk? (ppt, 317kb)
Abstract (pdf,10 kb) |
Martha Slattery, PhD
Professor, Internal Medicine, University of Utah |
What is the Evidence That Genetic Polymorphisms in the Vitamin D Receptor Influence Cancer Risk? Are There Ethnic Differences in These Polymorphisms and are These Related to Cancer Risk? (pdf, 32kb)
Abstract (pdf, 32kb) |
Sue Ingles, DrPH
Associate Professor, Preventive Medicine, University of Southern California |
Can Diet and/or Sunlight Exposure Influence the Relationship Between Vitamin D Receptor Polymorphisms and Cancer Risk? (ppt, 2.85mb)
Abstract (pdf, 9kb) |
Heide S. Cross, PhD
AssociateProfessor, Pathophysiology, Medical University of Vienna |
What is the Role of Extra-Renal Vitamin D Hydroxylase Expression and Activity in Normal and MalignantCells? How is this Modified by Epigenetic Mechanisms and Dietary Factors? (ppt, 18.53mb)
Abstract (pdf, 12kb) |
David Feldman, MD
Professor, Medicine/Endocrinology, Stanford University School of Medicine |
What is the Role of Vitamin D Mediated Inhibition of Prostaglandin Metabolism on Cancer Risk?
Abstract (pdf, 8kb) |
Nancy Weigel, PhD
Professor, Molecular and Cellular Biology, Baylor College of Medicine |
What is the Role of the Androgen Receptor in Mediating the Effects of Vitamin D? (ppt, 968kb)
Abstract (pdf, 9kb) |
Stephen Byers, PhD
Professor, Oncology, Georgetown University |
What is the Molecular Basis of VitaminD Receptor and β-catenin Cross-Regulation? (ppt, 3.69mb)
Abstract (pdf, 34kb) |
Heide S. Cross, PhD
Associate Professor, Pathophysiology, Medical University of Vienna |
How do Dietary Calcium, Folate, and Soy Regulate Colonic Vitamin D Synthesis? (ppt, 22.81mb)
Abstract (pdf, 34kb)
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Aruna Krishnan, PhD
Senior Research Scientist, Medicine, Division of Endocrinology, Stanford University |
What is the Molecular Mechanism Whereby Genistein Poteniates the Growth Inhibitory Effects of Vitamin D?
Abstract (pdf, 9kb) |
Ann Looker, PhD
Senior Scientist, Centers for Disease Control, National Center for Health Statistics |
How do Body Fat and Exercise Modulate Vitamin D Status? Do Ethnic Differences Modify this Relationship? (ppt, 89kb)
Abstract (pdf, 8kb) |
James Fleet, PhD
Professor, Department of Foods and Nutrition, Purdue University |
What have Genomic and Proteomic Approaches Told Us About Vitamin D and Cancer?
Abstract (pdf, 8kb) |
JoEllen Welsh, PhD
Professor, Biological Sciences, University of Notre Dame |
What is the Role of Dietary Calcium And Vitamin D in Vitamin D Receptor Knockout Animals? (ppt, 26.76mb)
Abstract (pdf, 21kb) |
Lenord Augenlicht, BA, PhD
Professor, Associate Director, Medicine and Cell Biology, Albert Einstein Cancer Center |
What are the Molecular Targets for Calcium and Vitamin D in Mouse Genetic Models for Cancer?
Abstract (pdf, 24kb) |
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Point of Contact
Cindy Davis, Ph.D
Program Director
Nutritional Science Research Group
Division of Cancer Prevention
National Cancer Institute, NIH, DHHS
6130 Executive Boulevard
Suite 3159
Rockville, MD 20892
Phone: 301-594-9692
Fax: 301-480-3925
E-mail: davisci@mail.nih.gov
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