Cloning Of GMEB 1 And 2: Two Proteins Involved In The Modulation Of Glucocorticoid Regulated Gene Transcription
Description of Invention:
This technology relates to a previously identified DNA element from a naturally occurring gene that has the properties of causing glucocorticoid induction at lower steroid concentrations than for other glucocorticoid inducible genes in the same cell. This DNA element, also called a glucocorticoid modulatory element, or GME, has been found to involve two proteins of 88 and 67 kDa.
This technology has succeeded in cloning and characterizing both the 67 kDa protein and the 88 kDa protein which together offer a unique and not previously described method of using genetic engineering to achieve selective regulation of glucocorticoid responsive genes. This group of proteins appears to be members of a larger class of related proteins which may have similar roles in modifying the activity of RNA polymerase II transcriptional complex.
For Additional Information Please Contact: Tara L. Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4426
Email: tarak@mail.nih.gov
Fax: (301)402-0220
