Description of Invention:
The present invention is directed to small, water-soluble peptides isolated from a native virus inhibitory sequence. The native peptide is involved in the step-wise autocatalytic maturation of the virally encoded protease in a pH dependent manner. The isolated peptide and its derivatives also inhibit the mature protease. The peptides and its derivatives may be used to treat virally infected cells, in preparing vaccine formulations, in generating clinically relevant antibodies and anti-idiotypic antibodies, and generating a screening assay or a kit that can be used to identify other similarly acting protease inhibitors.
Inventors:
John Louis Medabalimi (NIDDK)
Patent Status:
DHHS Reference No. E-138-1995/0 --
U.S. Patent 5,872,210 issued 16 Feb 1999
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
