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Prospective

Researchers: Structural Biology - New York University

Students do their dissertation research in the laboratories of both NIH and NYU researchers who have a strong interest in structural biology, including such areas as X-ray crystallography, electron microscopy, magnetic resonance imaging, mass spectrometry, and computational methods. A full description of the program can be found at http://saturn.med.nyu.edu/programs/sb/Sackler/. Currently, there are more than 40 faculty members in the program. For details about specific NIH and NYU researchers, respectively, students should visit the Web sites http://gpp.nih.gov/ or http://saturn.med.nyu.edu/programs/sb/Sackler/Faculty.html.   Listed below is a representative sample of structural biologists at NYU and NIH but there are many more investigators at NIH also doing structural biology-related research.

X-Ray Crystallography

New York University
Stevan Hubbard. Receptor tyrosine kinases.
Moosa Mohammadi. Signaling by fibroblast growth factors.
Da-Neng Wang. Transmembrane nutrient transporters.
Rui-Ming Xu. DNA replication and gene expression

National Institutes of Health
Susan Buchanan. Membrane protein structure.
Fred Dyda. Mechanisms of catalytic regulation.
David Garboczi. X-ray diffraction and immunology.
Traci Hall. Cell signaling and RNA-protein interactions.
James Hurley. Signal transduction and lipid signaling.
Peter Kwong. HIV vaccines.
Wei Yang. DNA recombination and repair.

Electron Imaging of Macromolecular Complexes and Membrane Proteins

New York University
Xiangpeng Kong. Epithelial membrane structure.
David Stokes. ATP-dependent ion transport and cell-cell junctions.

National Institutes of Health
Jenny Hinshaw. CryoEM of membrane trafficking.
Thomas Reese. Light and electron microscopy of transporting proteins in axons.
Alasdair Steven. CryoEM of virus replication.
Sriram Subramaniam. CryoEM of macromolecular assemblies.

Nuclear Magnetic Resonance Spectroscopy and Imaging

New York University
Oded Gonen. Functional MRI on human brains.
Joseph Helpern. Functional MRI on human brains.
Alexej Jerchow. Ion binding to DNA and proteins; methods development.
Daniel Turnbull. MRI and ultrasound on transgenic mice.

National Institutes of Health
Adriaan Bax. Protein structure determination and development of new methods.
Andrew Byrd. Gene expression.
Niko Tjandra, Application of Nuclear Magnetic Resonance in Biological Systems
Robert Tycko. Solid-state NMR of prion proteins.

Computational Methods

New York University
Stuart Brown. Bioinformatics.
Timothy Cardozo. Development of computational tools targeted at visualizing and engineering 3D structural features of molecules  
Yingkai Zhang - Protein catalysis and recognition
Tamar Schlick. Protein structure prediction and modeling.

National Institutes of Health
Stephen Bryant. Computational biology; protein structure prediction.
Tom Darden. Molecular modeling.

Proteomics

New York University
Thomas Neubert. Mass spectrometry and posttranslational modification.

National Institutes of Health
Sanford Markey. Proteomics of Neurodegenerative Processes.
Rodney Levine. Oxidative Signals and Oxidative Stress Affect Physiology and Disease

Other Methods

New York University
Joel Belasco. Interactions between RNA and regulatory proteins.
Nicholas Cowan. Protein folding in the eukaryotic cytosol.
Neville Kallenbach. Protein engineering and protein folding.
Nadrian Seeman. DNA nanotechnology.

National Institutes of Health
Debbie Hinton. Mechanisms of Transcription Initiation and Activation
Adrian Parsegian. Intermolecular force methods.
Rodney Levine. Oxidative Signals and Oxidative Stress Affect Physiology and Disease
Alfred Yergey. Mass spectrometric studies of posttranslational modifications.