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Federal Register Notice: Technical Reports Review

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http://ntp.niehs.nih.gov/go/14454

[Federal Register:April 9, 1999 (Volume 64, Number 68)]
[Notices]
[Page 17402]


Public Health Service

National Toxicology Program

>National Toxicology Program (NTP) Board of Scientific Counselors' Meeting;
Review of Draft NTP Technical Reports

Pursuant to Public Law 92-463, notice is hereby given of the next meeting of the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee on May 21, 1999, in the Rodbell Auditorium, Building 101, South Campus, National Institute of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. The meeting will begin at 8:45 a.m. on May 21 and is open to the public. The agenda topic is the peer review of draft Technical Reports of long-term toxicology and carcinogenesis studies from the National Toxicology Program.

Tentatively scheduled to be peer reviewed on May 21 are draft Technical Reports of four two-year studies, listed alphabetically, along with supporting information in the attached table. All studies were done using Fischer 344 rats and B6C3F1 mice. The order of review is given in the far right column of the table. By April 21, 1999, full copies of these draft reports will be available for free on the Internet for public review and comment through the Environmental Health Information Service (EHIS) at http://ehis.niehs.nih.gov. Printed copies can be obtained, as available, from: Central Data Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419), FAX (919/541-3687), email: CDM@niehs.nih.gov.

Public comment on any of the Technical Reports is welcome. Persons wanting to make a formal presentation regarding a particular Technical Report must notify the Executive Secretary by telephone at 919/541-3971, by FAX at 919/541-0295, by mail, or by email at hart@niehs.nih.gov, by no later than May 18, 1999, and, if possible, provide a written copy in advance of the meeting so copies can be made and distributed to all Subcommittee members and staff, and made available at the meeting for the public. Written statements could supplement and may expand on the oral presentation. Oral presentations should be limited to no more than five minutes.

The Program would welcome receiving toxicology and carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the chemicals listed in this announcement. Please contact Central Data Management at the address given above, and they will relay the information to the appropriate staff scientist.

The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709, will furnish agenda and a roster of Subcommittee members prior to the meeting. Summary minutes subsequent to the meeting will be available upon request to Central Data Management.

Attachment:

Dated: April 2, 1999

Samuel H. Wilson, M.D.
Deputy Director
National Institute of Environmental Health Sciences

[Billing Code 4140-01-P]


Summary Data for Technical Reports Tentatively Scheduled
for Review at the Meeting of the NTP Board of Scientific Counselor's
Technical Reports Review Subcommittee
May 21, 1999


Chemical
CAS Number

Technical
Report
Number


Primary
Uses

Route/
Exposure
Levels


Review
Order

Anthraquinone
84-65-1

TR-494

Intermediate in the manufacture of dyes and other organics. Organic inhibitor. Catalyst. Accelerator in nickel electroplating. Improving adhesion and heat stability of tire cord.

Feed:
Rats: 0, 469, 938, 1875, or 3750 ppm
Mice: 0, 833, 2500, or 7500 ppm

3

Emodin
518-82-1

TR-493

Major component of natural laxative drugs of plant origin. Medicine. Natural plant dye.

Feed:
Rats: 0, 280, 830, or 2500 ppm;
Mice: 0, 160, 312, 625, or 1250 ppm
(60/sex/species/group)

2

Fumonisin B1
116355-83-0

TR-496

Mycotoxin produced by certain strains of fusarium moniliforme, a commonly occurring fungi on U.S. agricultural products, especially corn. No known uses.

Feed:
Rats &Mice: 0, 5, 15, 50, 100, or 150 ppm

4

Gallium Arsenide
1303-00-0

TR-492

Semiconductors. Magnetoresistance devices. Light-emitting diodes. Microwave generation.

Inhalation
Rats: 0, 0.01, 0.1, or 1.0 mg/m3;
Mice: 0, 0.1, 0.5, or 1.0 mg/m3;
(50/group)

1