Press Center
Federal Register Notice: Request for Comments
[Federal Register: April 21, 1997 (Volume 62, Number 76)]
[Notices]
[Page 19348-19349]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institute of Environmental Health Sciences
National Toxicology Program
Announcement of Nominated Chemicals Approved and Under Consideration for Toxicological Studies by the National Toxicology Program (NTP) -- Request for Comments
As part of an effort to earlier inform and obtain public input
into the selection of chemicals for evaluation, the National Toxicology
Program (NTP) routinely announces in the Federal Register chemicals
nominated to the Program, recommended for toxicological studies
by the Interagency Committee for Chemical Evaluation and Coordination
(ICCEC), and approved for study by the NTP Executive Committee.
This announcement will allow interested parties to comment and
provide information on chemicals under consideration for study.
The Program would welcome receiving toxicology and carcinogenesis
information from completed, ongoing, or planned studies by others,
as well as current production data, human exposure information,
use patterns, and environmental occurrence for any of the chemicals
listed in this announcement. To provide comments or information,
please contact Dr. William Eastin at the address given below within
60 days of the appearance of this announcement.
At their meeting on February 7, 1997, the ICCEC reviewed and recommended
twelve chemicals or chemical classes for metabolism, toxicity,
or carcinogenicity studies. On February 27, 1997, the NTP Executive
Committee reviewed and approved the recommendations of the ICCEC.
Chemicals with CAS numbers, nomination source, types of studies
under consideration, and other supporting information are given
in the table.
Contact may be made by mail to: Dr. William Eastin, NIEHS/NTP,
P. O. Box 12233, Research Triangle Park, North Carolina 27709;
by telephone at (919) 541-7941; by FAX at (919) 541-4714; or by
email at Eastin@NIEHS.NIH.GOV.
Dated: April 10, 1997
______________________________
Kenneth Olden, Ph. D.
Director
National Toxicology Program
Attachment
[Billing Code 4140-01-P]
on February 27, 1997
| Chemical (CAS Number) |
Nomination Source |
Testing Recommendations |
Study Rationale/Remarks |
| Bromodichloroacetic Acid
(71333-14-7) |
EPA | Carcinogenicity; Reproductive, neurotoxicity screen; Genetic toxicity | - Water disinfectant byproduct, part of a class study |
| 2-Butyne-1,4-diol
(110-65-6) | NIEHS | Short and long-term toxicity; reproductive, neurotoxicity screen; metabolism; mechanistic studies | - Industrial intermediate, stabilizer, corrosion inhibitor
- Coordinate with EPA the testing planned through OECD-SIDS |
| Dibromoacetonitrile
(3252-42-5) | EPA | Carcinogenicity; Reproductive. neurotoxicity screen; in vivo micronucleus | - Water disinfectant byproduct, part of a class study |
| trans-1,4-Dichloro-2- butene
(110-57-6) | NIEHS | Carcinogenicity; Short-term toxicity | - High production volume
- Chemical intermediate - Human exposure not well defined - Extensive toxicity and carcinogenesis data received from industry may lead to deferral |
| Ethyl Bromoacetate
(105-36-2) | NCI | Metabolism studies | - May hydrolyze to bromoacetic acid
- Odorant in toxic gases - Chemical intermediate |
 -Hydroxy Acids (and their salts) - Glycolic Acid (79-14-1) - Lactic Acid (50-21-5) | FDA | Phototoxicity; Chronic toxicity; | - FDA's FY 1997 priority nomination
- Skin care product uses - Class study |
| Methyl Isobutyl Ketone
(108-10-1) | NCI | Carcinogenicity | - High production volume
- Environmental exposure |
| Methylamine
(74-89-5) | NCI;
Private individual | Pharmacokinetics | - Component of many foods |
 -Myrcene
(123-35-3) | NIEHS | Metabolism studies; Consider for carcinogenicity | - May be metabolized to a a diepoxide
- High production & high level of natural exposure |
| Octachloronaphthalene (2234-13-1) | NCI | Liver P450 enzyme induction; Estrogenic activity | - Potential to bioaccumulate and enter food chain as component of halowaxes |
| Propargyl Alcohol
(107-19-7) | NCI | Subchronic toxicity | - High production and human exposure |
| Sodium Thioglycolate
(367-51-1) | NCI | Reproductive toxicity | - High production and occupational and human exposure in hair care products |
