Protocol Number: 90-M-0142

Title:

Brain Procurement for the Neuropathology Section, CBDB

Number:

90-M-0142

Summary:

The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.

This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls.

Special Instructions:

Currently Not Provided

Keywords:

Schizophrenia

Neuropathology

Neurochemistry

Substance Abuse

Bipolar Disorder

Aging

Normal Development

Depression

Anxiety Disorders

Suicide

Recruitment Keyword(s):

Dementia

Depression

Bipolar Disorder

Neuropsychiatric Disorders

Suicide

Tourette's Syndrome

Normal Controls

Schizophrenia

Condition(s):

Bipolar Disorder

Depression

Anxiety Disorders

Schizophrenia

Tourette's Syndrome

Brain Diseases

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Mental Health

Contact(s):

Joel E. Kleinman, M.D.
National Institutes of Health
Building 10
Room 4S237A
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 402-7909
Fax: (301) 480-7795
Electronic Address: kleinmaj@intra.nimh.nih.gov

Citation(s):

Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest. 2007 Feb 8; [Epub ahead of print]

Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6747-52. Epub 2006 Apr 17.

Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9. Epub 2004 Aug 13.

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