| Disease/Syndrome |
Cadmium, chronic toxic effect |
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| Category |
Poisoning, Heavy Metal |
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| Acute/Chronic |
Chronic |
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| Synonyms |
Itai-itai disease |
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| Biomedical References |
Search PubMed |
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| Comments |
Acutely, cadmium exposure can cause delayed pulmonary edema and acute renal failure after inhalation of high concentrations of the fume. See "Pneumonitis, toxic" and "Acute tubular necrosis." Chronically, cadmium dust and fume are toxic primarily to the kidneys with secondary effects on the bones (osteomalacia). Biological monitoring of cadmium exposed workers is mandated by OSHA to prevent chronic renal disease. [LaDou, p. 418-20] Studies of heavily exposed workers have shown a latency of about 10 years before the onset of kidney damage. [ATSDR #10, p. 7] |
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| Latency/Incubation |
Weeks to years |
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| Diagnostic |
Urine and blood cadmium; Urine B2-microglobulins; When urinary cadmium level is less 10 micrograms/g. creatinine, then renal dysfunction is unlikely. |
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| ICD-9 Code |
985.5 |
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| Reference Link |
OSHA - Cadmium |
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| Related Information in Haz-Map |
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| Symptoms/Findings |
Symptoms/Findings associated with this disease:
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| Job Tasks |
High risk job tasks associated with this disease:
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| Agents |
Hazardous agents that cause the occupational disease:
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