| Agent Name |
4-Nitrophenol |
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| CAS Number |
100-02-7 |
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| Formula |
C6-H5-N-O3 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
4-Hydroxynitrobenzene; 4-Nitrofenol [Dutch]; 4-Nitrophenol; Niphen; PNP; Paranitrofenol [Dutch]; Paranitrofenolo [Italian]; Paranitrophenol; Paranitrophenol [French,German]; Phenol, 4-nitro-; Phenol, p-nitro-; p-Hydroxynitrobenzene; p-Nitrofenol [Czech]; p-Nitrophenol; [ChemIDplus] UN1663 |
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| Category |
Nitros, Aromatic |
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| Description |
Colorless to slightly yellow crystals; [HSDB] |
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| Sources/Uses |
Used as an intermediate for insecticides, fungicides, bactericides, and dyes; used as a leather treatment agent; [HSDB] Used to produce dyes, paints, rubber chemicals, and fungicides; [ATSDR ToxProfiles] |
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| Comments |
Methemoglobinemia has been reported. [HSDB] 4-Nitrophenol is more toxic than 2-nitrophenol in animals. Rats exposed to 2-nitrophenol at 112 mg/m3 for 2 weeks develop methemoglobinemia. No effect after dust exposures of 30 mg/m3 for 3-6 hours/day, 5 days a week for 4 weeks; [ATSDR ToxProfiles] A skin, eye, and respiratory tract irritant; May cause yellow stains on the skin; Can induce methemoglobinemia; May cause skin sensitization after prolonged contact; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
9.79 x 10 -05 mm Hg |
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| Explanatory Notes |
Flash point = 377 deg F; |
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| Reference Link |
ATSDR - ToxFAQs - Nitrophenols |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 4-NITROPHENOL
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