| Agent Name |
p-Anisidine |
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| CAS Number |
104-94-9 |
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| Formula |
C7-H9-N-O |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-4-methoxybenzene; 4-Aminoanisole; 4-Anisidine; 4-Methoxy-1-aminobenzene; 4-Methoxyaniline; 4-Methoxybenzenamine; 4-Methoxybenzeneamine; Aniline, 4-methoxy-; Aniline, p-methoxy-; Anisole, p-amino-; Benzenamine, 4-methoxy-; p-Aminoanisole; p-Anisylamine; p-Dianisidine; p-Methoxyaniline; p-Methoxyphenylamine; [ChemIDplus] UN2431 |
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| Category |
Amines, Aromatic |
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| Description |
Yellow to brown, crystalline solid with an amine-like odor; [NIOSH] |
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| Sources/Uses |
Both ortho and para isomers are used to produce azo dyes, while only the ortho form is used to produce synthetic guaiacol; [ACGIH] |
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| Comments |
Bladder cancer in animals observed in chronic feeding studies; Methemoglobinemia has been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] IARC classifies p-Anisidine as 3 (Not classifiable as to carcinogenicity to humans) and o-Anisidine as 2B (possibly carcinogenic to humans). A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.5 mg/m3 |
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| PEL (OSHA) |
0.5 mg/m3 |
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| IDLH (NIOSH) |
50 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with a only decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH. |
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| Vapor Pressure |
0.03 mm Hg |
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| Explanatory Notes |
Flash point = 5 deg C; [HSDB] |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: P-ANISIDINE
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