| Agent Name |
p-Nitrotoluene |
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| Alternative Name |
4-Nitrotoluene |
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| CAS Number |
99-99-0 |
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| Formula |
C7-H7-N-O2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Methyl-4-nitrobenzene; 4-Methylnitrobenzene; 4-Nitrotoluene; 4-Nitrotoluol; Nitrotoluenos [Spanish]; Toluene, p-nitro-; p-Methylnitrobenzene; p-Nitrotoluene; para-Nitrotoluol; [ChemIDplus] UN1664 |
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| Category |
Nitros, Aromatic |
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| Description |
Crystalline solid with a weak, aromatic odor; [NIOSH] |
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| Sources/Uses |
Used in the production of dyes, pesticides, and rubber chemicals; [ACGIH] |
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| Comments |
Nitrotoluenes (all isomers) have the potential to induce methemoglobinemia in the same manner as aniline and nitrobenzene. [ACGIH] Irritating to the eyes; Can induce methemoglobinemia; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
2 ppm |
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| PEL (OSHA) |
5 ppm |
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| MAK |
5 ppm |
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| IDLH (NIOSH) |
200 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for revised IDLH: Based on acute oral toxicity data in animals [Back et al. 1972; Vasilerko et al. 1978] and an analogy to nitrobenzene [Linch 1974] which has an IDLH of 200 ppm, the original IDLH for nitrotoluene (200 ppm) is not being revised at this time. |
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| Vapor Pressure |
0.1 mm Hg |
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| Odor Threshold Low |
0.00072 ppm |
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| Lethal Concentration |
LC50 (rats) = 975 mg/m3 |
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| Explanatory Notes |
Odor threshold (detection) from CHEMINFO; Flash point = 106 deg C; |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Primary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 4-NITROTOLUENE
|
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