| Agent Name |
Propylene dichloride |
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| Alternative Name |
1,2-Dichloropropane |
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| CAS Number |
78-87-5 |
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| Formula |
C3-H6-Cl2 |
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| Major Category |
Solvents |
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| Synonyms |
1,2-Dichloropropane; Bichlorure de propylene [French]; Dichloro-1,2 propane [ISO-French]; Dwuchloropropan [Polish]; alpha,beta-Dichloropropane; alpha,beta-Propylene dichloride; [ChemIDplus] UN1279 |
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| Category |
Chlorinated Solvents |
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| Description |
Colorless liquid with a chloroform-like odor. [pesticide]; [NIOSH] |
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| Sources/Uses |
Propylene dichloride is used as a solvent for many different purposes. [ACGIH] Used as a solvent in plastics, resins, fats & oils, metal degreasing, rubber processing, and dry cleaning; Used in past as a soil fumigant; [HSDB] |
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| Comments |
Acute inhalation studies of rats: anesthesia and elevation of liver enzymes; In occupational exposure, the liver and kidneys are the target organs. [ACGIH] In high-dose reproductive studies of male rats, 1,2-dichloropropane causes testicular damage. [Frazier, p. 248-9] Propylene dichloride is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; May cause kidney and liver injury; [ICSC] |
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| Reference Link |
Volatile Substance Abuse |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
75 ppm |
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| IDLH (NIOSH) |
400 ppm |
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| Vapor Pressure |
53.3 mm Hg |
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| Odor Threshold Low |
0.26 ppm |
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| Odor Threshold High |
0.52 ppm |
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| Lethal Concentration |
LC50 (rats) = 14,000 mg/m3/8H |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.26 ppm); Flash point = 16 deg C; |
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| Reference Link |
ATSDR ToxFAQs - 1,2-Dichloropropane |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Primary |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,2-DICHLOROPROPANE
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