| Agent Name |
Chlordecone |
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| Alternative Name |
Kepone |
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| CAS Number |
143-50-0 |
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| Formula |
C10-Cl10-O |
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| Major Category |
Pesticides |
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| Synonyms |
1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; 1,2,3,4,5,5,6,7,8,9,10,10-Dodecachlorooctahydro-1,3,4-metheno-2-cyclobuta(c,d)pentalone; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decano-4-one; 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-; 2,3,3a,4,5,6,7,7a,8,8a-Decachloro-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one; Chlordecone; Ciba 8514; Clordecone; Compound 1189; Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; Decachloroketone; Decachlorooctahydro-1,3,4-methano-2H-cyclobuta(cd)pentalen-2-one; Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; Decachloropentacyclo(5.2.1.0(2,6).0(3,9).0(5),(8))decan-4-one; Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one; Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one; Decachlorotetracyclodecanone; Decachlorotetrahydro-4,7-methanoindeneone; GC 1189; General chemicals 1189; Kepone; Kepone-2-one, decachlorooctahydro-; Merex; Perchloropentacyclo(5.3.0.0(2,6).0(3,9).0(4,8))decan-5-one; [ChemIDplus] |
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| Category |
Organochlorine Pesticides |
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| Description |
Tan to white, crystalline, odorless solid. [insecticide]; [NIOSH] |
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| Sources/Uses |
Formerly used as an insecticide; Base material for the manufacture of kelevan; [HSDB] |
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| Comments |
In the past, workers in a manufacturing plant developed "Kepone shakes" with tremor, weakness, and slurred speech. Abnormal liver function tests were also seen. [Sullivan, p. 1078-9] Workers had decreased sperm counts. There is strong positive data and limited negative data that chlordecone causes fetal loss in animals. [ATSDR Case Studies #29] |
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| Restricted |
In 1975 the sole manufacturer of Kepone in the U.S. was ordered to terminate production. [Sullivan, p. 1048-9] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Bioaccumulates |
Yes |
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| Vapor Pressure |
3 x 10 -07 mm Hg |
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| Explanatory Notes |
NIOSH REL = 0.001 mg/m3; |
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| Reference Link |
ATSDR - ToxFAQs - Mirex and Chlordecone |
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| Adverse Effects |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Reproductive Toxin |
Yes |
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| Other Poison |
Organochlorine Pesticide |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: KEPONE
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