| Agent Name |
Cyclohexylamine |
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| CAS Number |
108-91-8 |
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| Formula |
C6-H13-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Aminocyclohexane; 1-Cyclohexylamine; Aminocyclohexane; Aminohexahydrobenzene; Aniline, hexahydro-; Benzenamine, hexahydro-; CHA; Cyclohexanamine; Cyclohexylamine; Hexahydroaniline; Hexahydrobenzenamine; [ChemIDplus] UN2357 |
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| Category |
Amines, Heterocyclic |
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| Description |
Colorless or yellow liquid with a strong, fishy, amine-like odor; [NIOSH] |
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| Sources/Uses |
Used to inhibit corrosion in boiler feed water and to manufacture "insecticides, plasticizers, dry-cleaning soaps, rubber chemicals, dye stuffs, and gas absorbents." [ACGIH] |
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| Comments |
Cyclohexylamine has moderate skin sensitizing potential and is a weak methemoglobin inducer. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Merck Index # 2729; Causes second and third degree burns after short skin exposure; [CHRIS] Corrosive to skin; [Quick CPC] Corrosive to the skin, eyes, and respiratory tract; Inhalation of high concentrations may cause CNS effects; [ICSC] No apparent effects in workers exposed to 4-10 ppm; Inhalation of high concentrations could cause pulmonary edema; A 25% solution produced severe irritation of the skin in humans; [CHEMINFO] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
10 ppm |
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| MAK |
2 ppm |
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| Vapor Pressure |
10.1 mm Hg |
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| Odor Threshold Low |
2.6 ppm |
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| Odor Threshold High |
110 ppm |
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| Lethal Concentration |
LC50 (rats) = 7,500 mg/m3 |
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| Explanatory Notes |
Flash point = 88 deg F; Odor thresholds from CHEMINFO; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CYCLOHEXYLAMINE
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