| Agent Name |
1,2-Dichloroethylene, all isomers |
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| Alternative Name |
Acetylene dichloride |
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| CAS Number |
540-59-0, 156-59-2, 156-60-5 |
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| Formula |
C2-H2-Cl2 |
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| Major Category |
Solvents |
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| Synonyms |
Acetylene dichloride; cis-Acetylene dichloride; trans-Acetylene dichloride; sym-Dichloroethylene; [NIOSH] 1,2-Dichloroethene; Dioform; [ChemIDplus] UN1150 |
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| Category |
Chlorinated Solvents |
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| Description |
Colorless liquid (usually a mixture of the cis & trans isomers) with a slightly acrid, chloroform-like odor; [NIOSH] |
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| Sources/Uses |
Used as a solvent and chemical intermediate; [ACGIH] Used as a refrigerant, degreaser, dry cleaning agent, and solvent for perfumes, adhesives, lacquers, oils, and resins; [HSDB] |
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| Comments |
Liver injury observed in acute animal toxicology studies; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
200 ppm |
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| PEL (OSHA) |
200 ppm |
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| MAK |
200 ppm |
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| IDLH (NIOSH) |
1000 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: Patty [1963] reported that rats exposed to the cis�isomer of dichloroethylene for 4 hours at 8,000 ppm were neither killed nor anesthetized, but at 16,000 ppm, anesthesia occurred in 8 minutes and death occurred in 4 hours [Smyth 1956]. Because Patty [1963] also reported that the trans�isomer was twice as toxic an anesthetic as the cis�isomer, an IDLH of 4,000 ppm is chosen. . . . Human data: It has been reported that exposure to the trans�isomer at 2,200 ppm caused burning of the eyes, vertigo, and nausea [von Oettingen 1955]. An exposure to the trans�isomer at 819 ppm for 30 minutes has been reported to cause no untoward effects, while inhalation of either 1,687 to 2,184 ppm for 5 minutes or 1,191 ppm for 10 minutes has resulted in vertigo, pressure in the head, and somnolence [von Oettingen 1937]. |
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| Vapor Pressure |
201 mm Hg |
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| Odor Threshold Low |
0.08 ppm |
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| Odor Threshold High |
17 ppm |
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| Lethal Concentration |
LC50 (mice) = 21,723 ppm/6H (trans-isomer); |
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| Explanatory Notes |
Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; VP = 180-265 mm Hg; Flash point = 2 deg C; |
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| Reference Link |
ATSDR ToxFAQs - 1,2-Dichloroethene |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,2-DICHLOROETHYLENE
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