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Agent Name 1-Bromopropane CAS Number 106-94-5 Formula C3-H7-Br Major Category Solvents Synonyms N-Propyl bromide; Propane, 1-bromo-; Propyl bromide; n-Propyl bromide; [ChemIDplus] n-Propylbromide; Propylbromide;1-BP; [ACGIH] UN2344 Category Brominated Solvents Description Colorless liquid; [ACGIH] Sources/Uses Used as a solvent substitute "to clean metals and electronics, in adhesive and coating applications, and in aerosol propellant applications." [ACGIH] Comments If left on clothes, may cause reddening of skin; [CHRIS] Low acute toxicity; A case of peripheral neuropathy was reported in a 19 year old male after 2 months of occupational exposure to a degreasing solvent containing 95.5% 1-BP. Reproductive toxicity and hepatoxiicty are observed in animals repeatedly exposed to levels above 100 ppm and 200 ppm, respectively. [ACGIH] 1-BP causes neurotoxicity and reproductive toxicity in animal studies. A study of 27 workers producing 1-BP in a Chinese factory found evidence of toxicity to the CNS and peripheral nerves. [Reference #1] Six cases of neurotoxicity (? central distal axonopathy) were reported among foam cushion gluers. [Reference #2] Potential adverse effects include CNS depression and anesthesia; [HSDB] See "2-Bromopropane." Reference Link Neurologic abnormalities in workers of a 1-bromopr...[Environ Health Perspect. 2004] - PubMed Result Exposure Assessment Skin Designation (ACGIH) No TLV (ACGIH) 10 ppm Vapor Pressure 146 mm Hg Lethal Concentration LC50 (rats) =253,000 mg/m3/30 min Reference Link Severe neurotoxicity associated with exposure to t...[Clin Toxicol (Phila). 2007] - PubMed Result Flammability (NFPA) 2: high ambient temperature required Adverse Effects Dermatotoxin Skin Burns Neurotoxin CNS Solvent Syndrome Hepatotoxin Hepatotoxin, Secondary Reproductive Toxin Yes Links to Other NLM Databases Health Studies Human Health Effects from Hazardous Substances Data Bank: 1-BROMOPROPANE   Toxicity Information Search TOXNET Chemical Information Search ChemIDplus Biomedical References Search PubMed Related Information in Haz-Map Diseases Occupational diseases associated with exposure to this agent: Encephalopathy, chronic solvent Neuropathy, toxic Solvents, acute toxic effect Processes Industrial Processes with risk of exposure: Metal Degreasing Painting (Solvents) Working with Glues and Adhesives

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