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Vilhelm A. Bohr, M.D., Ph.D., Senior Investigator Chief, Section on DNA Repair Laboratory of Molecular Gerontology Phone: 410-558-8223 Fax: 410-558-8157 E-mail: bohrv@grc.nia.nih.gov |
| Biography: Dr. Bohr received his M.D. in 1978, Ph.D. in 1987, and D.Sc. in 1987 from the University of Copenhagen, Denmark. After training in neurology and infectious diseases at the University Hospital in Copenhagen, Dr. Bohr did a postdoctoral fellowship with Dr. Hans Klenow at the University of Copenhagen, Denmark. He then worked with Dr. Philip Hanawalt at Stanford University as a research scholar from 1982-1986. In 1986 he was appointed to the National Cancer Institute (NCI) as an investigator, becoming a tenured Senior Investigator in 1988. Dr. Bohr developed a research section in DNA repair at the NCI. In 1992 he moved to the NIA to become Chief of the Laboratory of Molecular Genetics, renamed Laboratory of Molecular Gerontology in February 2001. |
| The Section on DNA Repair examines the role of the increased DNA damage accumulation in senescence as the major molecular change with aging. The goal is to understand the underlying mechanisms involved in DNA damage formation and it�s processing as well as the changes that take place with aging that make aging cells susceptible to cancer. Investigative focus is placed on investigating the molecular mechanisms involved in DNA repair and in genomic instability in normal, senescent and cancer cells. The Unit on Premature Aging Disorders studies the molecular functions and protein interactions of the premature aging proteins, Werner syndrome and Cockayne syndrome. The Unit on Oxidative DNA Damage Processing and Mitochondrial Functions focuses on mitochondrial DNA, and the studies seek to investigate the basis for the mitochondrial hypothesis of aging which states that accumulation of DNA damage with aging leads to the phenotypical changes that we observe in senescence and age-associated disease. The mechanisms of removal of oxidative DNA damage from mitochondria are investigated and how they are affected by increasing age or disease processes. |
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| Section on DNA Repair (left to right). Row 1: Lale Dawut, Marie Rossi, Rebecca Greaves, Deborah Croteau; row 2: Jane Tian, Lisa Martin, Jenq-Lin Yang, Zheng Wang; row 3: Cynthia Kasmer, Lorraine Oliver, Vilhelm Bohr, Dharmendra Singh; row 4: Maria Aamann, Guido Keijzers, Ghosh Avik, Scott Maynard; row5: Jason Aulds, Regina Knight, Tomasz Kulikowicz, Shepherd Schurman, Alfred May. Not shown: Lior Weissman and Jason Piotrowski. |
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