National Institute on Aging
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Tamara B. Harris, M.D., M.S. Tamara B. Harris, M.D., M.S., Senior Investigator
Chief, Geriatric Epidemiology Section
Laboratory of Epidemiology, Demography, and Biometry

E-mail: harrista@nia.nih.gov
Biography: Dr. Harris received her M.D. degree from Albert Einstein College of Medicine, New York, New York in 1978. She trained in internal medicine at Montefiore Hospital, Bronx, New York and in geriatric medicine at Harvard University, Division on Aging, where she was a Kaiser Fellow in Geriatric Medicine. She obtained a M.S. in Epidemiology from Harvard School of Public Health and also has a M.S. in Human Nutrition from Columbia University College of Physician's and Surgeons. From Harvard, she joined the Office of Analysis and Epidemiology at the National Center for Health Statistics. Dr. Harris moved to the National Institute on Aging in 1991, where she is Chief of the Geriatric Epidemiology Section. Dr. Harris has developed the Geriatric Epidemiology Section to cover a broad range of topics ranging from molecular and genetic epidemiology and body composition to health disparities. The goal of this research is to identify new risk factors for disease and disability amenable to intervention.
Research Overview: The role of the Geriatric Epidemiology Section is to integrate molecular and genetic epidemiology with interdisciplinary studies of functional outcomes, disease endpoints and mortality in older persons. This includes identification of novel risk factors and design of studies involving biomarkers, selected polymorphisms and exploration of gene/environment interactions. The Section has been particularly active in devising methods to integrate promising molecular or imaging techniques in ways that begin to explore the physiology underlying epidemiologic associations including adaptaton of imaging protocols to epidemiologic studies. The major areas of research include:
Health Studies in Relation to Weight and Body Composition: Despite the fact that overweight is well-accepted as a risk factor for disease, disability and death in younger populations, there remains controversy about the optimal level of weight in old age. This is further complicated by age-associated changes in body fat, bone and muscle and questions regarding the contribution of sarcopenia, or age-related muscle loss, to declines in aerobic capacity and function with age. The Geriatric Epidemiology Section initiated the Health, Aging and Body Composition Study (Health ABC) in 1996 to investigate these questions. The major study objective is to examine whether change in body composition, particularly loss of muscle, represents a common pathway by which multiple conditions contribute to disability. Since little was known about sarcopenia in an unselected population, the Health ABC population was selected as well-functioning and relatively health-stable, but at high risk of health transitions secondary to age, race and gender characteristics. The Health ABC cohort consists of 3,075 black and white men and women aged 70-79 (46 percent of the women and 37 percent of the men enrolled are black) who initially reported no difficulty walking at least 1/4 mile and or up a flight of stairs. The major study outcome is report of new limitation in walking 1/4 mile or up stairs, complemented by assessment of performance on a 400-meter walk, quadriceps strength, and other objective functional tests. Morbidity and mortality are also assessed.
The study was designed around the hypothesis that factors affecting body composition and loss of muscle would be consistent across all four race/sex groups and that factors in three key areas would modulate loss of muscle including: metabolic dysregulation, particularly inflammation or genetic factors; episodes of acute illness; and patterns of change in physical activity. A battery of detailed physiologic measurements and questionnaire material was developed to follow change over the 7-year period of examinations that is part of the study and that covers a period of rapid health transitions. All critical measures will be repeated during this time (see website: http://www.grc.nia.nih.gov/branches/ledb/healthabc/index.htm). We have established a large repository of specimens and continue to seek innovative ideas and collaborators for the use of these samples.
One important finding from this study is the characterization of the extent of fatty infiltration into muscle and the metabolic and functional correlates. The Geriatric Epidemiology Section has organized a series of studies to investigate this finding in more detail including collaborating with investigators who have a large library of full-body MRI scans to assess fatty infiltration by age, race and level of physical activity and molecular studies of muscle and fat tissue from several locations in the body.
The Geriatric Epidemiology Section also has an ancillary study in the Osteoarthritis Initiative to investigate the relationship of muscle mass in the leg, strength, and the importance of fatty infiltration into muscle in relationship to incidence and progression of knee osteoarthritis. This involves a measure of quadriceps and hamstrings strength as well as a protocol for imaging of the muscles of the leg with a quantitative assessment of muscle lipid.
Causes and Consequences of Inflammation in Diseases of Old Age: The focus of efforts in the Geriatric Epidemiology Section has been on the contribution of chronic low-level inflammation to health outcomes apart from cardiovascular disease, and to understanding what conditions and behaviors appear to be linked to low-level inflammation. A number of data sets have been used to explore the relationship of chronic low-level inflammation with health risks in old age. These efforts have involved studies of mortality, disability, cardiovascular disease, diabetes and glucose metabolism, smoking and pulmonary function, cognition, and weight and fat distribution. Visceral fat has been identified as the fat depot most consistently associated with higher levels of cytokines; however, fat infiltrating into muscle also appears to be associated with higher cytokines as well. There is on-going analysis of these data to assess whether the poor health outcomes associated with elevated cytokines is due to direct effects of elevated cytokines or whether the elevated cytokines represent severity of the underlying condition and the condition ultimately is responsible for the increased health risk.
Assessing the Genetic Contribution to Diseases of Old Age: The Geriatric Epidemiology Section initiated and works collaboratively with the Neuroepidemiology Section on the Age, Gene/Environment Susceptibility (AGES) Study. This study, established collaboratively with the Icelandic Heart Association, consists of a follow-up examination of an established cohort of about 12,000 people in the birth cohorts of 1907-1935 previously examined in the Reykjavik Study. The AGES Study goals include: identification of genetic and other new risk factors for selected diseases and conditions including: atherosclerosis, cognitive impairment, dementia and subtypes (i.e. Alzheimer's disease), stroke, sarcopenia, obesity, osteoporosis, diabetes, and osteoarthritis; characterization of phenotypes for these diseases and conditions to study them in relation to genetic susceptibility, gene function and genetic/environmental contributions to disease; and identification of contributory molecular markers associated with these conditions including markers of cellular maintenance and repair, markers of oxidative stress, and immunologic and endocrine indicators.
The Geriatric Epidemiology Section has also carried out studies of selected polymorphisms pertinent to inflammation and body composition measures in nested case-control studies in the Health ABC Study and in other datasets developed for this purpose. Efforts have been made to broaden the application of emerging techniques for genomic and proteomic studies to populations by development of new methods in collaboration with laboratory-based investigators.
Publications:

  • Atkinson HH, Rosano C, Simonsick EM, Williamson JD, Davis C, Ambrosius WT, Rapp SR, Cesari M, Newman AB, Harris TB, Rubin SM, Yaffe K, Satterfield S, Kritchevsky SB; for the Health ABC study. Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2007;62(8):844-850.

  • Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB; for the Health ABC Study. Inflammatory markers and incident fracture risk in older men and women: The Health Aging and Body Composition Study. J Bone Miner Res. 2007;22(7):1088-1095.

  • Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, Tylavsky FA, Newman AB; Health, Aging and Body Composition Study. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55(5):769-774.

  • Ding J, Kritchevsky SB, Newman AB, Taaffe DR, Nicklas BJ, Visser M, Lee JS, Nevitt M, Tylavsky FA, Rubin SM, Pahor M, Harris TB; the Health ABC Study. Effects of birth cohort and age on body composition in a sample of community-based elderly. Am J Clin Nutr. 2007;85(2):405-410.

  • Faulkner KA, Redfern MS, Cauley JA, Landsittel DP, Studenski SA, Rosano C, Simonsick EM, Harris TB, Shorr RI, Ayonayon HN, Newman AB; Health, Aging, and Body Composition Study. Multitasking: association between poorer performance and a history of recurrent falls. J Am Geriatr Soc. 2007;55(4):570-576.

  • Fried LF, Biggs ML, Shlipak MG, Seliger S, Kestenbaum B, Stehman-Breen C, Sarnak M, Siscovick D, Harris T, Cauley J, Newman AB, Robbins J. Association of kidney function with incident hip fracture in older adults. J Am Soc Nephrol. 2007;18(1):282-286.

  • Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, Harris TB, Hanlon JT, Rubin SM, Shorr RI, Bauer DC, Abernethy DR. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167(8):781-787.

  • Houston DK, Ding J, Nicklas BJ, Harris TB, Lee JS, Nevitt MC, Rubin SM, Tylavsky FA, Kritchevsky SB. The association between weight history and physical performance in the Health, Aging and Body Composition study. Int J Obes (Lond). 2007 May; [Epub ahead of print].

  • Keller CR, Odden MC, Fried LF, Newman AB, Angleman S, Green CA, Cummings SR, Harris TB, Shlipak MG. Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the Health, Aging, and Body Composition Study. Kidney Int. 2007;71(3):239-244.

  • Mackey DC, Gaare Eby J, Harris F, Taaffe DR, Cauley JA, Tylavsky FA, Harris TB, Lang TF, Cummings SR; for the Health, Aging, and Body Composition Study Group. Prediction of clinical non-spine rractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: The Health, Aging, and Body Composition Study. J Bone Miner Res. 2007 August; [Epub ahead of print].

  • Manini TM, Clark BC, Nalls MA, Goodpaster BH, Ploutz-Snyder LL, Harris TB. Reduced physical activity increases intermuscular adipose tissue in healthy young adults. Am J Clin Nutr. 2007;85(2):377-384.

  • Manini TM, Visser M, Won-Park S, Patel KV, Strotmeyer ES, Chen H, Goodpaster B, De Rekeneire N, Newman AB, Simonsick EM, Kritchevsky SB, Ryder K, Schwartz AV, Harris TB. Knee extension strength cutpoints for maintaining mobility. J Am Geriatr Soc. 2007;55(3):451-457.

  • Nevitt MC, Peterfy C, Guermazi A, Felson DT, Duryea J, Woodworth T, Chen H, Kwoh K, Harris TB. Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss. Arthritis Rheum. 2007;56(5):1512-1520.

  • Park SW, Goodpaster BH, Strotmeyer ES, Kuller LH, Broudeau R, Kammerer C, de Rekeneire N, Harris TB, Schwartz AV, Tylavsky FA, Cho YW, Newman AB; Health, Aging, and Body Composition Study. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the Health, Aging, and Body Composition Study. Diabetes Care. 2007;30(6):1507-1512.

  • Pope SK, Kritchevsky SB, Morris MC, Block G, Tylavsky FA, Lee JS, Stewart S, Harris T, Rubin SM, Simonsick EM. Cognitive ability is associated with suspected reporting errors on food frequency questionnaires. J Nutr Health Aging. 2007;11(1):55-58.

  • Ruhl CE, Harris TB, Ding J, Goodpaster BH, Kanaya AM, Kritchevsky SB, Simonsick EM, Tylavsky FA, Everhart JE. Body mass index and serum leptin concentration independently estimate percentage body fat in older adults. Am J Clin Nutr. 2007;85(4):1121-1126.

  • Schaap LA, Pluijm SM, Deeg DJ, Penninx BW, Nicklas BJ, Lips P, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, Goodpaster BH, Tylavsky FA, Yaffe K, Visser M; for the Health ABC study. Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. Clin Endocrinol (Oxf). 2007 July; [Epub ahead of print].

  • Shaffer JR, Kammerer CM, Reich D, McDonald G, Patterson N, Goodpaster B, Bauer DC, Li J, Newman AB, Cauley JA, Harris TB, Tylavsky F, Ferrell RE, Zmuda JM; for the Health ABC study. Genetic markers for ancestry are correlated with body composition traits in older African Americans. Osteoporos Int. 2007;18(6):733-741.

  • Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 2007;68(22):1902-1908.

  • Vogelzangs N, Beekman AT, Kritchevsky SB, Newman AB, Pahor M, Yaffe K, Rubin SM, Harris TB, Satterfield S, Simonsick EM, Penninx BW. Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2007;62(5):563-569.

  • Wassel Fyr CL, Kanaya AM, Cummings SR, Reich D, Hsueh WC, Reiner AP, Harris TB, Moffett S, Li R, Ding J, Miljkovic-Gacic I, Ziv E; for the Health, Aging, Body Composition Study. Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study. Hum Genet. 2007;121(5):615-624.

  • Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx B, Satterfield S, Harris T, Cummings SR; Health ABC Investigators. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiol Aging. 2007;28(2):171-178.

  • Yende S, Angus DC, Ali IS, Somes G, Newman AB, Bauer D, Garcia M, Harris TB, Kritchevsky SB. Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc. 2007;55(4):518-525.

  • Angleman SB, Harris TB, Melzer D. The role of waist circumference in predicting disability in periretirement age adults. Int J Obes (Lond). 2006;30(2):364-373.

  • Eiriksdottir G, Aspelund T, Bjarnadottir K, Olafsdottir E, Launer LJ, Harris TB, Gudnason V. Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study. Atherosclerosis. 2006;186(1):222-224.

  • Kanaya AM, Wassel Fyr C, Vittinghoff E, Harris TB, Park SW, Goodpaster BH, Tylavsky F, Cummings SR. Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med. 2006;166(3):350-356.

  • Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB. Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition Study cohort. J Gerontol A Biol Sci Med Sci. 2006;61(1):72-77.

  • Pettee KK, Brach JS, Kriska AM, Boudreau R, Richardson CR, Colbert LH, Satterfield S, Visser M, Harris TB, Ayonayon HN, Newman AB. Influence of marital status on physical activity levels among older adults. Med Sci Sports Exerc. 2006;38(3):541-546.

  • Shlipak MG, Wassel Fyr CL, Chertow GM, Harris TB, Kritchevsky SB, Tylavsky FA, Satterfield S, Cummings SR, Newman AB, Fried LF. Cystatin C and mortality risk in the elderly: The Health, Aging, and Body Composition Study. J Am Soc Nephrol. 2006;17(1):254-261.

  • Yende S, Waterer GW, Tolley EA, Newman AB, Bauer DC, Taaffe DR, Jensen R, Crapo R, Rubin S, Nevitt M, Simonsick EM, Satterfield S, Harris T, Kritchevsky SB. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax. 2006;61(1):10-16.

  • Angleman SB, Harris TB, Melzer D. The role of waist circumference in predicting disability in periretirement age adults. Int J Obes (Lond). 2005;30(2):364-373.

  • Cesari M, Kritchevsky SB, Nicklas BJ, Penninx BW, Holvoet P, Koh-Banerjee P, Cummings SR, Harris TB, Newman AB, Pahor M. Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study. Arch Intern Med. 2005;165(18):2148-2154.

  • Cesari M, Kritchevsky SB, Penninx BW, Nicklas BJ, Simonsick EM, Newman AB, Tylavsky FA, Brach JS, Satterfield S, Bauer DC, Visser M, Rubin SM, Harris TB, Pahor M. Prognostic value of usual gait speed in well-functioning older people-results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53(10):1675-1680.

  • Fried LP, Hadley EC, Walston JD, Newman A, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ. 2005;2005(31):pe24.

  • Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, Visser M, Harris TB. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr. 2005;81(4):903-910.

  • Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Simonsick EM, Nevitt M, Holvoet P, Newman AB. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med. 2005;165(7):777-783.

  • Helzner EP, Cauley JA, Pratt SR, Wisniewski SR, Talbott EO, Zmuda JM, Harris TB, Rubin SM, Taaffe DR, Tylavsky FA, Newman AB. Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study. Osteoporos Int. 2005;16(12):1675-1682.

  • Helzner EP, Cauley JA, Pratt SR, Wisniewski SR, Zmuda JM, Talbott EO, Rekeneire N, Harris TB, Rubin SM, Simonsick EM, Tylavsky FA, Newman AB. Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53(12):2119-2127.

  • Hicks GE, Simonsick EM, Harris TB, Newman AB, Weiner DK, Nevitt MA, Tylavsky FA. Cross-sectional associations between trunk muscle composition, back pain, and physical function in the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2005;60(7):882-887.

  • Hicks GE, Simonsick EM, Harris TB, Newman AB, Weiner DK, Nevitt MA, Tylavsky FA. Trunk muscle composition as a predictor of reduced functional capacity in the Health, Aging and Body Composition Study: the moderating role of back pain. J Gerontol A Biol Sci Med Sci. 2005;60(11):1420-1424.

  • Il'yasova D, Colbert LH, Harris TB, Newman AB, Bauer DC, Satterfield S, Kritchevsky SB. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev. 2005;14(10):2413-2418.

  • Katsiaras A, Newman AB, Kriska A, Brach J, Krishnaswami S, Feingold E, Kritchevsky SB, Li R, Harris TB, Schwartz A, Goodpaster BH. Skeletal muscle fatigue, strength and quality in the elderly: The Health ABC Study. J Appl Physiol. 2005;99(1):210-216.

  • Kern LM, Powe NR, Levine MA, Fitzpatrick AL, Harris TB, Robbins J, Fried LP. Association between screening for osteoporosis and the incidence of hip fracture. Ann Intern Med. 2005;142(3):173-181.

  • Koster A, Penninx BW, Bosma H, Kempen GI, Newman AB, Rubin SM, Satterfield S, Atkinson HH, Ayonayon HN, Rosano C, Yaffe K, Harris TB, Rooks RN, Van Eijk JT, Kritchevsky SB. Socio-economic differences in cognitive decline and the role of biomedical factors. Ann Epidemiol. 2005;15(8):564-571.

  • Lee JS, Kritchevsky SB, Harris TB, Tylavsky F, Rubin SM, Newman AB. Short-term weight changes in community-dwelling older adults: the Health, Aging, and Body Composition Weight Change Substudy. Am J Clin Nutr. 2005;82(3):644-650.

  • Newman AB, Lee JS, Visser M, Goodpaster BH, Kritchevsky SB, Tylavsky FA, Nevitt M, Harris TB. Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study. Am J Clin Nutr. 2005;82(4):872-878.

  • Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB. Association of visceral adipose tissue With incident myocardial infarction in older men and women: The Health, Aging and Body Composition Study. Obstet Gynecol Surv. 2005;60(3):173-175.

  • Reiner AP, Ziv E, Lind DL, Nievergelt CM, Schork NJ, Cummings SR, Phong A, Burchard EG, Harris TB, Psaty BM, Kwok PY. Population structure, admixture, and aging-related phenotypes in African American adults: The Cardiovascular Health Study. Am J Hum Genet. 2005;76(3):463-477.

  • Rodondi N, Newman AB, Vittinghoff E, de Rekeneire N, Satterfield S, Harris TB, Bauer DC. Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med. 2005;165(21):2460-2466.

  • Rodondi N, Vittinghoff E, Cornuz J, Butler J, Ding J, Satterfield S, Newman AB, Harris TB, Hulley SB, Bauer DC; Health, Aging, and Body Composition Study research group. Aspirin use for the primary prevention of coronary heart disease in older adults. Am J Med. 2005;118(11):1288.

  • Rosano C, Simonsick EM, Harris TB, Kritchevsky SB, Brach J, Visser M, Yaffe K, Newman AB. Association between physical and cognitive function in healthy elderly: the Health, Aging and Body Composition Study. Neuroepidemiology. 2005;24(1-2):8-14.

  • Sahyoun NR, Anderson AL, Kanaya AM, Koh-Banerjee P, Kritchevsky SB, de Rekeneire N, Tylavsky FA, Schwartz AV, Lee JS, Harris TB. Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults. Am J Clin Nutr. 2005;82(3):547-552.

  • Schoeller DA, Tylavsky FA, Baer DJ, Chumlea WC, Earthman CP, Fuerst T, Harris TB, Heymsfield SB, Horlick M, Lohman TG, Lukaski HC, Shepherd J, Siervogel RM, Borrud LG. QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. Am J Clin Nutr. 2005;81(5):1018-1025.

  • Schwartz AV, Sellmeyer DE, Strotmeyer ES, Tylavsky FA, Feingold KR, Resnick HE, Shorr RI, Nevitt MC, Black DM, Cauley JA, Cummings SR, Harris TB; for the Health ABC Study. Diabetes and bone loss at the hip in older black and white adults. J Bone Miner Res. 2005;20(4):596-603.

  • Snijder MB, Visser M, Dekker JM, Goodpaster BH, Harris TB, Kritchevsky SB, De Rekeneire N, Kanaya AM, Newman AB, Tylavsky FA, Seidell JC; for the Health ABC Study. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia. 2005;48(2):301-308.

  • Taaffe DR, Newman AB, Haggerty CL, Colbert LH, de Rekeneire N, Visser M, Goodpaster BH, Nevitt MC, Tylavsky FA, Harris TB. Estrogen replacement, muscle composition, and physical function: The Health ABC Study. Med Sci Sports Exerc. 2005;37(10):1741-1747.

  • Visser M, Goodpaster BH, Kritchevsky SB, Newman AB, Nevitt M, Rubin SM, Simonsick EM, Harris TB. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci. 2005;60(3):324-333.

  • Visser M, Kritchevsky SB, Newman AB, Goodpaster BH, Tylavsky FA, Nevitt MC, Harris TB. Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study. Am J Clin Nutr. 2005;82(3):531-537.

  • Visser M, Simonsick EM, Colbert LH, Brach J, Rubin SM, Kritchevsky SB, Newman AB, Harris TB; for the Health ABC Study. Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters. J Am Geriatr Soc. 2005;53(5):762-770.

  • Zamboni M, Mazzali G, Zoico E, Harris TB, Meigs JB, Di Francesco V, Fantin F, Bissoli L, Bosello O. Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes Relat Metab Disord. 2005;29(9):1011-1029.

  • Harris TB. Cholesterol and health in old age: risk factor or risk marker? J. Am. Geriatr. Soc. 2004;52(4):639-640.

  • Holvoet P, Kritchevsky SB, Tracy RP, Mertens A, Rubin SM, Butler J, Goodpaster B, Harris TB. The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the Health, Aging, and Body Composition Cohort. Diabetes. 2004;53(4):1068-1073.

  • Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, Kritchevsky SB, Fellin R, Harris TB. Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study. Circulation. 2004;109(5):607-612.

  • Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Tracy RP, Rubin SM, Harris TB, Pahor M. Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am. J. Cardiol. 2003;92(5):522-528.

  • De Rekeneire N, Resnick HE, Schwartz AV, Shorr RI, Kuller LH, Simonsick EM, Vellas B, Harris TB. Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study. Diabetes Care. 2003;26(12):3257-3263.

  • de Rekeneire N, Rooks RN, Simonsick EM, Shorr RI, Kuller LH, Schwartz AV, Harris TB; Health, Aging and Body Composition Study. Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition Study. Diabetes Care. 2003;26(7):1986-1992.

  • Taaffe DR, Lang TF, Fuerst T, Cauley JA, Nevitt MC, Harris TB. Sex- and race-related differences in cross-sectional geometry and bone density of the femoral mid-shaft in older adults. Ann. Hum. Biol. 2003;30(3):329-346.

  • Taaffe DR, Simonsick EM, Visser M, Volpato S, Nevitt MC, Cauley JA, Tylavsky FA, Harris TB; Health ABC Study. Lower extremity physical performance and hip bone mineral density in elderly black and white men and women: cross-sectional associations in the Health ABC Study. J. Gerontol. A Biol. Sci. Med. Sci. 2003;58(10):M934-M942.

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Updated: Thursday October 11, 2007