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Protocol Number:
07-C-0028
- Title:
Screening of Mannose-Binding Lectin (MBL) Status in Pediatric Hematology/Oncology Patients
- Number:
07-C-0028
- Summary:
Background:
Infections are a major cause of sickness and death in children with cancer.
Studies show that a protein called mannose-binding lectin (MBL) is important in immunity and that changes in blood levels of MBL are associated with serious infectious complications when the immune system is stressed.
A new genetically engineered MBL protein called rhMBL may be useful in treating some patients with low MBL levels.
Objectives:
To learn more about MBL in children with cancer.
To identify pediatric cancer patients with low MBL levels who may be eligible to participate in a future study of rhMBL therapy.
Eligibility:
Children with cancer between 2 and 17 years of age who were previously enrolled in an NIH study for cancer evaluation or treatment.
Design:
Blood samples will be obtained to study MBL in children with cancer.
Children found to have a low blood level of MBL may be offered enrollment in a treatment study using rhMBL.
- Sponsoring Institute:
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National Cancer Institute (NCI)
- Recruitment Detail
- Type:
Clinical hold/Recruitment or enrollment suspended
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
-
Infection
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Immunogenicity
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Innate Immunity
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C4 Deposition
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Host Defense
- Recruitment Keyword(s):
-
Cancer
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Infection
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Hematological Disease
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Pediatrics
- Condition(s):
-
Mannose-Binding Lectin Deficiency
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
-
National Cancer Institute
- Contact(s):
-
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Anders EM, Hartley CA, Reading PC, Ezekowitz RA. Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. J Gen Virol. 1994 Mar;75 ( Pt 3):615-22.
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Babula O, Danielsson I, Sjoberg I, Ledger WJ, Witkin SS. Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol. 2004 Sep;191(3):762-6.
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Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis. 2003 Sep 1;37(5):733-7. Epub 2003 Aug 13.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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