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Protocol Number:
03-H-0201
- Title:
Cytokine Gene Polymorphisms in Allotransplant Donors
- Number:
03-H-0201
- Summary:
This study seeks to investigate the factors that may account for the differences in the way a stem cell recipient's immune system works after a transplant. It will focus on cytokine genes, which give specific instructions to the genes and which may influence immune system response. More specifically, the purpose of the study is to find out how gene polymorphisms (gene variations among the population) affect the success or failure of a stem cell transplant.
Study participants will have donated blood for a stem cell transplant. They will be asked to give consent for NIH personnel to run special tests on these blood samples, which will have been placed in storage. It is hoped that blood samples will be studied from 600 stem cell donors.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
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Tumor Necrosis Factor Alpha (TNF-Alpha)
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Interferon-Gamma (IFN-Gamma)
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Interleukin-10 (IL-10)
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Interleukin-6 (IL-6)
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Interleukin-1 (IL-1 Ra)
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Interleukin-1 Receptor Antagonist (IL-1 Ra)
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Vitamin D Receptor (VitD R)
- Recruitment Keyword(s):
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None
- Condition(s):
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Stem Cell Transplantation
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
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National Heart, Lung and Blood Institute
- Contact(s):
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Socie G, et al., Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transplantation. 2001 Aug 27;72(4):699-706. PMID: 11544434
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Cavet J, et al., Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood. 1999 Dec 1;94(11):3941-6. PMID: 10572111
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Cavet J, et al., Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood. 2001 Sep 1;98(5):1594-600. PMID: 11520812
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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