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Protocol Number:
02-M-0281
- Title:
The Characterization of Childhood Onset Obsessive Compulsive Disorder and the PANDAS Subgroup
- Number:
02-M-0281
- Summary:
The purpose of this study is to learn more about Obsessive-compulsive Disorder (OCD) in children. OCD usually has a slow onset, and symptoms that may remain at a stable level over time. A subset of children with OCD has a sudden onset and symptoms that fluctuate in severity over time. This study will also compare healthy children to those with OCD. This is an observational study; children who participate will not receive any new or experimental therapies.
OCD affects nearly 1% of the pediatric population. The symptoms of this illness can interrupt development, causing significant psychological distress and producing life-long impairments in social, academic, and occupational functioning. A subgroup of pediatric OCD has been designated by the acronym PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). This type of OCD is characterized by sudden symptom onset and a relapsing-remitting course of illness; exacerbation of symptoms occurs with scarlet fever or strep. throat infections. This study will identify factors that distinguish children with PANDAS OCD from children with non-PANDAS OCD, and will compare both groups to healthy children.
Children with OCD and their parents are screened with interviews and a review of the child's medical records. Participants have an initial evaluation that includes a psychiatric, physical and neuromotor exam, neuropsychological testing, psychological interviews, and a blood test. Structural magnetic resonance imaging (MRS) scans of the brain are also obtained. The MRS scan does not use radiation.
After the initial evaluation, children with OCD have follow-up visits every 6 weeks for 12 to 24 months. They are seen yearly for 8 years after the study. If they have a significant improvement or worsening of their symptoms, they are asked to make a maximum of two extra visits. Parents of OCD patients are called four times a year to discuss any changes in the child's condition between yearly visits. All participants have a 1-year follow-up visit upon study completion.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
No longer recruiting/follow-up only
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
-
Tic Disorders
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Neurophyschological
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Immunology
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Magnetic Resonance Imaging
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Basal Ganglia
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Obsessive-Compulsive Disorder
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Children
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Adolescents
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Magnetic Resonance Spectroscopy
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PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated d
- Recruitment Keyword(s):
-
Obsessive Compulsive Disorder
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OCD
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Healthy Volunteers
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HV
- Condition(s):
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Obsessive-Compulsive Disorder
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
-
National Institute of Mental Health
- Contact(s):
-
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
-
Rosenberg DR, Keshavan MS, O'Hearn KM, Dick EL, BagwellWW, Seymour AB, Montrose DM, Pierri JN, Birmaher B. Frontostriatal measurement in treatment-naive children with bsessive-compulsive disorder. Arch Gen Psychiatry. 1997Sep;54(9):824-30.
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Snider LA, Lougee L, Slattery M, Grant P, Swedo SE. Antibioticprophylaxis with azithromycin or penicillin forchildhood-onset neuropsychiatric disorders. Biol Psychiatry.2005 Apr 1;57(7):788-92.
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Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl. 1998;(35):26-37. Review.
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Bethesda, Maryland 20892. Last update: 01/13/2009
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