Protocol Number: 02-M-0036

Title:

A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control

Number:

02-M-0036

Summary:

The purpose of this study is to determine how the brain controls motor activity in children with attention deficit hyperactivity disorder (ADHD).

The inability to control one's behavior is an important symptom of many psychiatric illnesses. The stop signal paradigm which involves withholding a motor response to a go signal, has proved useful in assessing uncontrolled behavior in children with ADHD and other disorders. This study will use a stop signal paradigm in order to evaluate the ability of children with and without ADHD to control their motor behavior. A magnetic resonance imaging (MRI) scan will be used to study how the brain works during specific activities.

This study will evaluate the stop signal paradigm in three groups of people: healthy children, children with ADHD, and healthy adults. This study comprises two sub-studies: a behavioral study in which participants perform simple activities and an MRI study.

Participants will be asked to stop any over-the-counter medication 5 days before entering the behavioral or MRI study. Children with ADHD will be asked to stop taking medication for ADHD 72 hours before the study. All participants will have a medical history and a psychiatric evaluation (for children, both parents and children provide information for the assessment). Participants in the MRI study will also have physical examinations and blood and urine tests. All children will undergo intelligence tests; and those with ADHD will have tests to confirm the diagnosis. The parents of child participants will complete an autism screening questionnaire.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Stop Task

ADHD

Impulsivity

Functional MRI

Developmental

Inhibitory Control

Attention Deficit Hyperactivity Disorder

Recruitment Keyword(s):

ADHD

Attention Deficit Hyperactivity Disorder

Impulsivity

Healthy Volunteer

Normal Volunteer

HV

Condition(s):

Attention Deficit Hyperactivity Disorder

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Institute of Mental Health

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Response inhibition in AD/HD, CD comorbid AD/HD + CD, anxious, and control children: A meta-analysis of studies with the stop task

Structural and functional brain development and its relation to cognitive development

Basal ganglia thalamocortical circuits: Parallel substrates for motor, oculomotor, prefrontal, and limbic functions

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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