Protocol Number: 02-D-0169

Title:

Complex Regional Pain Syndrome Proteomics Study

Number:

02-D-0169

Summary:

This study will try to learn more about complex regional pain syndrome, or CRPS (previously known as reflex sympathetic dystrophy, spreading neuralgia, and sympathalgia), by examining the release of small proteins in the blood of patients with this condition. Patients with CRPS usually have three types of symptoms:

- Sensory abnormalities - increased sensitivity to pain or a painful reaction to a harmless stimulus

- Perfusion abnormalities - alterations in blood flow, temperature abnormality, swelling, decrease or increased nail growth, and hair and skin changes

- Motor abnormalities - weakness, guarding (Holding the limb in such a fashion that it minimizes accidental or intentional contact from possible sources of pain), and atrophy (wasting)

The cause of CRPS is unknown, and there are no definitive diagnostic tests for the condition. Because early treatment improves the prognosis of CRPS, a test that enables early diagnosis would be important for optimal medical management. The findings of this study may contribute to the development of such a test and possibly new drug treatments.

Normal healthy volunteers and patients of any age with complex regional pain syndrome who are in otherwise good general health may be eligible for this study.

Participants will have a medical history, physical examination and collection of a blood sample. They will fill out several questionnaires, providing information on their health, personality, mood, pain levels, and symptoms. Participation in the study requires one outpatient clinic visit.

Sponsoring Institute:

National Institute of Dental And Craniofacial Research (NIDCR)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

CRPS

RSD

Causalgia

Chronic Pain

Neuropathic Pain

Recruitment Keyword(s):

Normal Control

Complex Regional Pain Syndrome

CRPS

RSD

Healthy Volunteer

HV

Condition(s):

Complex Regional Pain Syndromes

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Institute of Dental and Craniofacial Research

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Bichsel VE, Liotta LA, Petricoin EF 3rd Cancer proteomics: from biomarker discovery to signal pathway profiling Cancer J 2001 Jan-Feb;7(1):69-78 Review.

Bittner M, Molecular classification of cutaneous malignant melanoma by gene expression profiling Nature 2000 Aug 3;406(6795):536-40.

Chelimsky TC, Low PA, Naessens JM, Wilson PR, Amadio PC, O'Brien PC Value of autonomic testing in reflex sympathetic dystrophy Mayo Clin Proc 1995 Nov;70(11):1029-40.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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