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Protocol Number:
08-CH-0001
- Title:
Calibration of Non-Invasive Non-ionizing Imaging Techniques to Study Vasculature of Healthy Volunteers
- Number:
08-CH-0001
- Summary:
This study will explore the uses of three noninvasive imaging techniques-thermography, laser Doppler imaging, and multispectral imaging-to test the blood flow of healthy volunteers. By comparing these three techniques, researchers will be able to train these imaging systems to better evaluate skin types and blood flow. The study will also test computer programs that have been developed to correct for the effects of curvature and body hair on the images.
Healthy volunteers must be older than 18 years of age and may not have had a history of malignant tumors, skin disease, or vascular disease.
Participants will undergo the following procedures on an outpatient basis:
Three different types of images taken of the participant's forearm
-Thermography - infrared thermal imaging to map skin temperature
-Laser Doppler imaging - low-powered laser imaging to map blood flow in the skin
-Multispectral imaging - near-infrared light imaging to measure total blood flow and oxygen levels in the skin
A reactive hyperemia experiment, in which multispectral images will be taken of the participant's forearm during and after the use of a blood pressure cuff
A hair removal experiment, in which images will be collected of the participant's forearm in separate scans done before and after the hair is removed with a topical hair removal solution
The entire series of exams will take approximately one hour to perform.
- Sponsoring Institute:
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National Institute of Child Health and Human Development (NICHD)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Age 18 years or greater.
EXCLUSION CRITERIA:
-Healthy volunteers with any skin disease.
-Past or present history of malignant tumors.
-Past or present hematologic abnormality of Hgb less than 9.0 gm/dl.
-Healthy volunteers with any past or present vein disease.
-Any medical condition that, in the opinion of the Principal Investigator, would preclude the inclusion of a patient onto this research study.
-Unable or unwilling to give informed consent.
- Special Instructions:
Currently Not Provided
- Keywords:
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Imaging
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Multi-Spectral Imaging
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Thermography
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Laser Doppler Imaging
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Vasculature
- Recruitment Keyword(s):
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Healthy Volunteer
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HV
- Condition(s):
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Healthy Volunteers Only
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Child Health and Human Development
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Thorniley M, Sinclair J, Barnett N, Shurey C, Green C. The use of near-infrared spectroscopy for assessing flap viability during reconstructive surgery. Br J Plast Surg 1998;51(3):218-26.
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Wolf M, Weber O, Keel M, Golay X, Scheidegger M, Bucher HU, Kollias S, Boesiger P, BÌ?nziger O. Comparison of cerebral blood volume measured by near infrared spectroscopy and contrast enhanced magnetic resonance imaging. Adv Exp Med Biol 1999;471:767-73.
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Essex T, Byrne P. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng 1991;13(3):189-94.
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Bethesda, Maryland 20892. Last update: 01/13/2009
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