INCLUSION CRITERIA:
Inclusion Criteria for Patients
1. Patients known to have, or suspected of having an infection susceptibility will be eligible for enrollment.
2. Patients with known or suspected infections will also be eligible in order to identify the microbiologic cause of the infection, identify the extent of infection, or determine the proper course of treatment. There will be no limit as to age, sex, race or disability.
3. Patients must have a primary physician outside of the NIH and may be required to submit a letter from their physician that documents their relevant health history.
4. The patient or the patient's guardian will be willing and capable of providing informed consent after initial counseling by clinical staff. Separate consent forms for all interventional procedures will be obtained after explanation of the specific procedure.
5. Women of childbearing potential, or who are pregnant or lactating, may be eligible. Interventions in pregnant or lactating women will minimize as much as possible risks to the fetus/infant but will follow state of art evaluation and therapy. Should a woman become pregnant or suspect she may be pregnant while participating in this study, she should inform the study staff and her primary care physician immediately.
6. Patients must agree to have blood stored for future studies of the immune system and/or other medical conditions.
7. Patients may be concurrently enrolled on other protocols as long as the Principal Investigator is informed.
Inclusion Criteria for Healthy Blood Relatives of Patients:
1. Healthy blood relatives of patients known to have or suspected of having an infection susceptibility will be eligible for enrollment only if they have a sick relative who is enrolled on this protocol as a patient.
2. There will be no limit as age, sex, race or disability.
3. Relatives or the minor relative's guardian must be willing and capable of providing informed consent after initial counseling by clinical staff.
4. Participating relatives agree to have blood stored for future studies of the immune system and/or other medical conditions.
EXCLUSION CRITERIA:
1. A well understood acquired abnormality which leads to infection susceptibility, such as HIV, cytotoxic chemotherapy, or active malignancy may be adequate explanation for the infection diathesis. These may be grounds for exclusion if, in the opinion of the investigators, the presence of such disease process interferes significantly with evaluation (applicable to patients and their blood relatives).
2. Severe or uncommon infections or syndromes often require highly specialized teams and institutions. Some referred cases will not be able to be handled appropriately at the NIH and may be deemed ineligible for admission, as determined by the Principal Investigator.