Protocol Number: 05-M-0144

Title:

MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

Number:

05-M-0144

Summary:

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Age: 18-65 years

Diagnosis: Healthy

EXCLUSION CRITERIA:

Serious medical illness (including diabetes) as determined from H& P or laboratory testing

Prescription psychotropic medication; drug free period must be greater than 3 weeks for anticholinergics and benzodiazepine and greater than 8 weeks for fluoxetine, antipsychotics, anticonvulsants

Claustrophobia

Pregnancy; women with child bearing potential will have pregnancy test to exclude pregnancy

Any condition that increases risk for MRI (e.g., pacemaker, metallic foreign body in the eye, etc.)

Unable to lay on one's back for MRI/MRS scans

Positive HIV test

Special Instructions:

Currently Not Provided

Keywords:

Glutamate

Excitatory Amino Acid

Neurochemistry

GABA

Magnetic Resonance Spectroscopy

Recruitment Keyword(s):

None

Condition(s):

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

Procedure/Surgery: Magnetic Resonance Spectroscopy

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Gruetter R, Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem. 1994 Oct;63(4):1377-85.

Malloy CR, Analysis of tricarboxylic acid cycle of the heart using 13C isotope isomers. Am J Physiol. 1990 Sep;259(3 Pt 2):H987-95.

Shen J, Magnetic resonance spectroscopic approaches to studying neuronal: glial interactions. Biol Psychiatry. 2002 Oct 1;52(7):694-700.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home

National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 01/13/2009