Protocol Number: 05-M-0105
Children between 8 and 17 years of age with attention deficit hyperactivity disorder (ADHD) or anti-social behavior or who are healthy normal volunteers may be eligible for this study. Candidates are screened with a medical history and physical examination, mental health and psychiatric interviews, blood test, and urine drug screen. Children who are taking atomoxetine (Stattera), bupropion (Wellbutrin), modafinil (Provigil), or similar medications for behavioral problems are excluded. Participants have the following procedures over two separate visits: - Visits 1 & 2, Standardized testing: Children undergo standardized tests designed to measure language, math, memory abilities, and intelligence. Children with ADHD or behavior problems must not take any medications for their disorder, such as stimulants related to amphetamine or methylphenidate for 48 hours before testing, and no over-the-counter medications for 5 days before testing. Healthy control participants must not take any prescription or over-the-counter medicines for 5 days before testing. In addition to testing, participants learn how magnetic resonance imaging (MRI) scans are performed in preparation for the next visit. A urine sample is collected for a drug screen. - Visit 3, MRI scan: MRI uses strong magnetic fields and radio waves to measure changes in brain tissues. During the procedure, the child lies on a table in a space encircled by a metal cylinder (the MRI scanner) for 60 to 90 minutes and must lie still for 10 to 15 minutes at a time. While in the scanner, the child is asked to perform some tasks on the computer involving responding to pictures or making simple decisions. Children with ADHD or behavior problems must not take any medications for their disorder, such as stimulants related to amphetamine or methylphenidate, for 48 hours before scanning, and no over-the-counter medications for 5 days before MRI scanning. Healthy control participants must not take any prescription or over-the-counter medicines for 5 days before the scan. A urine sample is collected for a drug screen before the test. Female participants are tested for pregnancy before the scan and are not scanned if the pregnancy test is positive. Participants may be invited to participate in a genetics study and a study of fatty acids in the blood.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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