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Protocol Number:
03-EI-0122
- Title:
Evaluation of Immune Responses to Different Antigens in Non Infectious Ocular Inflammatory Diseases
- Number:
03-EI-0122
- Summary:
This study will collect blood samples from patients with non-infectious eye inflammatory diseases-a spectrum of eye disorders that can produce sight-threatening vision loss. The blood will be analyzed for substances that may provide a better understanding of the nature of these disorders, possibly leading to improved treatments. Treatment is not offered under this protocol.
Patients 6 years of age and older with an eye inflammatory disease, including non-infectious uveitis, ocular cicatricial pemphigoid, non-infectious scleritis, episcleritis, Stevens Johnson syndrome, Moorens ulcer, peripheral ulcerative keratitis and keratoconjunctivitis sicca, may be eligible for this study. Patients may or may not currently be participating in a treatment trial.
Participants will have blood drawn through a needle in an arm vein. More samples may be collected if patients enrolled in another study are scheduled for additional visits. No more than 4 teaspoonfuls of blood will be collected at any one time.
- Sponsoring Institute:
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National Eye Institute (NEI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Participant is 6 years or older.
Participant is able to understand and sign the informed consent and if the participant is younger than 18 years of age at enrollment, has a parent or legal guardian who is able to understand and sign the consent on their behalf.
Patients must have a diagnosis of ocular inflammatory diseases.
EXCLUSION CRITERIA:
Patient under 6 years of age.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Autoimmunity
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Cell Mediated Immunity
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S Antigen
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Cell Proliferation
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Uveitis
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Cell Proliferation Assays
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Auto-Antibody
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Auto-Antigens
- Recruitment Keyword(s):
-
None
- Condition(s):
-
Eye Diseases
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Eye Institute
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Foster CS, et al. The immunopathology of Mooren's ulcer.Am J Ophthalmol. 1979 Aug;88(2):149-59.
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Nussenblatt RB, et al. Cellular immune responsiveness of uveitis patients to retinal S-antigen. Am J Ophthalmol. 1980 Feb;89(2):173-9.
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Murray PI, Rahi AH. Pathogenesis of Mooren's ulcer: some new concepts. Br J Ophthalmol. 1984 Mar;68(3):182-7.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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