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Protocol Number:
92-EI-0113
- Title:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans
- Number:
92-EI-0113
- Summary:
The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.
- Sponsoring Institute:
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National Eye Institute (NEI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
1. Participants must be undergoing an eye procedure for clinical care of their condition which requires the removal of tissue specimens or have agreed pre-mortem to donate their eyes after death for research purposes.
2. Participants must agree to the de-identified storage of their sample for potential use in future research projects.
3. For conditions where blood is needed for analysis, participants must consent to having blood drawn for research evaluation, and be able to safely give a blood sample.
4. Participants must be able to give informed consent for themselves and/or their minor children who wish to enroll.
EXCLUSION CRITERIA:
1. Participant is unwilling or unable to give informed consent.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Ocular Pathology
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Ocular Immunology
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Clinicopathological Correlation
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Immunohistochemical Methods
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In Situ Hybridization
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Polymerase Chain Reaction
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Microdissection
- Recruitment Keyword(s):
-
Ocular Disease
- Condition(s):
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Conjunctival Disease
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Corneal Disease
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Eye Disease
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Uveitis
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Vitreoretinopathy, Proliferative
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Eye Institute
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Molecular pathology of primary intraocular lymphoma. Chan CC. Trans Am Ophthalmol Soc. 2003;101:275-92.
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Molecular pathology of age-related macular degeneration. Ding X, Patel M, Chan CC. Prog Retin Eye Res. 2008 Nov 6.
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Immunopathology of uveitis. Chan CC, Li Q. Br J Ophthalmol. 1998 Jan;82(1):91-6.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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