NIH Clinical Research Studies

Protocol Number: 91-CH-0127

Active Accrual, Protocols Recruiting New Patients

Title:
Ovarian Follicle Function in Patients with Premature Ovarian Failure
Number:
91-CH-0127
Summary:
Premature ovarian failure may be the result of the destruction of eggs in the ovaries. Some patients experience complete destruction of all eggs within the ovaries. In these cases, no treatment will restore egg development.

However, some patients experience a condition known as premature autoimmune ovarian failure. In these cases eggs still remain in the ovaries, but they are prevented from working normally by the body's own immune system.

This study was designed to evaluate patients with premature ovarian failure. It will provide researchers with information that may be used later in other studies related to this condition. In addition, patients participating in this study may be selected for other studies that may benefit them directly.

Sponsoring Institute:
National Institute of Child Health and Human Development (NICHD)
Recruitment Detail
Type: Participants currently recruited/enrolled
Gender: Female
Referral Letter Required: Yes
Population Exclusion(s): Male

Children

Eligibility Criteria:
INCLUSION CRITERIA:

Women 18 to 42 years of age with premature ovarian failure who meet the following requirements will be candidates for the study: 1) at least a four month history of amenorrhea not due to pregnancy, and 2) at least two documented serum FSH levels or two documented LH levels in the menopausal range for the corresponding assay (greater than or equal to 20 U/ml for FSH and greater than or equal to15 U/L for LH in the current Clinical Center assays).

EXCLUSION CRITERIA:

Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian failure will not be candidates.

Special Instructions:
Currently Not Provided
Keywords:
Menopause
Estrogen
Infertility
Ovulation
Amenorrhea
Hypergonadotropic Hypogonadism
Young Women
Gonadal Steroid Deficiency
Mineralocorticoid Deficiency
Recruitment Keyword(s):
Premature Ovarian Failure
POF
Condition(s):
Amenorrhea
Hypoaldosteronism
Hypogonadism
Infertility
Premature Ovarian Failure
Investigational Drug(s):
None
Investigational Device(s):
None
Intervention(s):
None
Supporting Site:
National Institute of Child Health and Human Development

Contact(s):
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):
Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure

The use of human recombinant gonadotropin receptors to search for IgG mediated premature ovarian failure

Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure

Active Accrual, Protocols Recruiting New Patients

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