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Protocol Number:
90-M-0142
- Title:
Brain Procurement for the Neuropathology Section, CBDB
- Number:
90-M-0142
- Summary:
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.
This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Schizophrenia
-
Neuropathology
-
Neurochemistry
-
Substance Abuse
-
Bipolar Disorder
-
Aging
-
Normal Development
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Depression
-
Anxiety Disorders
-
Suicide
- Recruitment Keyword(s):
-
Dementia
-
Depression
-
Bipolar Disorder
-
Neuropsychiatric Disorders
-
Suicide
-
Tourette's Syndrome
-
Normal Controls
-
Schizophrenia
- Condition(s):
-
Bipolar Disorder
-
Depression
-
Anxiety Disorders
-
Schizophrenia
-
Tourette's Syndrome
-
Brain Diseases
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Mental Health
- Contact(s):
-
Joel E. Kleinman, M.D.
National Institutes of Health Building 10 Room 4S237A 10 Center Drive Bethesda, Maryland 20892 Phone: (301) 402-7909 Fax: (301) 480-7795 Electronic Address: kleinmaj@intra.nimh.nih.gov
- Citation(s):
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Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest. 2007 Feb 8; [Epub ahead of print]
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Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6747-52. Epub 2006 Apr 17.
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Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9. Epub 2004 Aug 13.
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Bethesda, Maryland 20892. Last update: 01/13/2009
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