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Protocol Number:
84-D-0056
- Title:
Evaluation and Treatment of Salivary Gland Dysfunction
- Number:
84-D-0056
- Summary:
This study will evaluate patients with complaints of dry mouth to determine the cause and severity of their salivary gland dysfunction and their possible eligibility for other NIDCR protocols. Salivary gland secretions have antibacterial, lubricatory, remineralizing, digestive, buffering and cleansing properties. Impaired function of these glands can cause an increase in tooth decay; a variety of oral hard and soft tissue changes, with painful, burning, or ulcerated oral mucosal; problems chewing, swallowing, and speaking; and diminished taste and smell.
Patients with dry mouth complaints suggestive of salivary gland dysfunction may be eligible for this study. In addition, patients with recent onset of arthritis may enroll. Patients with arthritis are at risk for developing a disorder called Sjogren's syndrome, in which the glands that produce saliva may be damaged.
Participants will have a complete medical and dental history. Saliva samples will be collected from the major salivary glands, which are located in the cheeks and under the jaw. Several blood samples will also be drawn for tests. Some patients will have a biopsy of the minor salivary glands, usually from the lower lip, to confirm or rule out the diagnosis of Sjogren's syndrome and determine the extent of changes in the salivary glands. The ability to taste and smell may also be evaluated, and patients may have an ultrasound examination of their swallowing function.
- Sponsoring Institute:
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National Institute of Dental And Craniofacial Research (NIDCR)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
Patients with symptoms of oral dryness.
- Special Instructions:
Protocol is primarily seeking patients with Sjogren's syndrome, primary type.
- Keywords:
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Parotid Gland
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Submandibular/Sublingual Glands
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Xerostomia
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Radiation Therapy
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Sjogren's Syndrome
- Recruitment Keyword(s):
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Dry Mouth
- Condition(s):
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Sjogren's Syndrome
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Xerostomia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Dental and Craniofacial Research
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Xerostomia: Evaluation of a symptom with increasing significance
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The salivary and oral components of Sjogren's syndrome
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Current concepts of autoimmune exocrinopathy: Immunologic mechanisms in the salivary pathology of Sjogren's syndrome
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/13/2009
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