NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

80 Protocols (60 Active Accrual of new subjects, 20 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 09-DK-0058:
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

* 09-DK-0055:
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

* 08-DK-0187:
Natural History and Pathophysiology of Gastrointestinal Graft Versus Host Disease

* 08-DK-0182:
Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C

* 08-DK-0173:
A Trial of Segmental Stiffening Wires to Improve the Efficiency and Patient Tolerability of Colonoscopy

* 08-DK-0165:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

* 08-DK-0157:
A Trial of Oral Nifedipine for the Treatment of Iron Overload

* 08-DK-0149:
High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed After Standard Therapy

* 08-DK-0138:
A New Method for Determining Gastric Acid Output Using a Wireless Capsule

* 08-DK-0106:
Hepatitis C Eradication and Progression of Atherosclerosis

* 08-DK-0098:
Natural History of Familial Carcinoid Tumor

* 08-DK-0004:
High Throughput Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

* 07-DK-0219:
A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism

* 07-DK-0212:
Prospective Evaluation of Albuminuria in HIV Positive Patients

* 07-DK-0207:
Tenofovir Disoproxil Fumarate Alone Versus its Combination with Emtricitabine for Treatment of Chronic Hepatitis B

* 07-DK-0202:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Exposure to Cold Temperature in Humans

* 07-DK-0163:
The Effect of Diet on Vascular Disease: A Study of Pre-Menopausal African American and Caucasian Women

* 07-DK-0143:
Effects of S-Adenosyl Methionine (SAMe) on Viral and Cell Signaling Response to Combination Therapy for Chronic Hepatitis C

* 07-DK-0115:
Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults with Type 2 Diabetes Mellitus

* 07-DK-0077:
Study of the Phenotype of Overweight and Obese Adults

* 06-DK-0183:
Gene Expression and Release of Inflammatory Mediators in Overweight Subjects Before and After Weight Loss

* 06-DK-0142:
Peripheral Blood Collection of Adult Stem Cells

* 06-DK-0133:
Thyroid Hormone-Induced Lipolysis: An In Vivo Microdialysis Study

* 06-DK-0079:
The Role of the Orexin System in Body Weight Regulation: Patients with Narcolepsy

* 06-DK-0036:
Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity

* 06-DK-0025:
The Effects of Lithium Carbonate on Low Dose Radioiodine Ablation in Early Thyroid Cancer Treatment

* 06-DK-0020:
Kidney Disease Biomarkers

* 05-DK-0119:
Peripheral Thyroid Hormone Conversion and Glucose and Energy Metabolism

* 05-DK-0085:
Clinical and Laboratory Investigation of Humans with Informative Iron or Erythroid Phenotypes

* 05-DK-0015:
Retinoids for Podocyte Disease

* 04-DK-0061:
A Comparison of Free Fatty Acid Flux in African Americans and Caucasians

* 04-DK-0021:
Urinary Vitamin C Loss in Subjects with and without Diabetes

* 03-DK-0257:
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance

* 03-DK-0256:
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics

* 03-DK-0226:
Pulse Dexamethasone Over 48 Weeks for Podocyte Disease

* 03-DK-0098:
Study of Thyrotropin Releasing Hormone in Patients with Thyroid or Pituitary Abnormalities

* 02-DK-0107:
Investigation of Neurodegeneration in Glycosphingolipid Storage Disorders

* 02-DK-0022:
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy

* 01-DK-0247:
Treatment of Chronic Delta Hepatitis with Pegylated Interferon

* 01-DK-0062:
Genetic Analysis of Familial Keloids

* 01-DK-0053:
Permeability Factor in Focal Segmental Glomerulosclerosis

* 00-DK-0221:
Evaluation of the Immune Response in Humans After Exposure to Hepatitis C Virus

* 00-DK-0125:
Immunogenetics of Hepatitis C Virus Infection

* 00-DK-0107:
Search for Novel Methods to Detect Acute Renal Failure

* 99-DK-0119:
Monitoring for Donor-Specific Hyporesponsiveness Following Renal and Pancreatic Allotransplantation

* 99-DK-0002:
Heart Disease Risk Factors in African Americans

* 94-DK-0133:
Genetic Markers for Focal Segmental Glomerulosclerosis

* 94-DK-0127:
Pathogenesis of Glomerulosclerosis

* 93-DK-0127:
Family Studies in Metabolic Diseases and Mineral Metabolism

* 92-DK-0156:
Studies of Immunologically-Mediated Kidney Diseases

* 91-DK-0214:
Evaluation of Patients with Liver Disease

* 91-DK-0085:
Studies of Hyperparathyroidism and Related Disorders

* 91-DK-0066:
Fasting Hypoglycemia: Diagnosis and Treatment

* 89-DK-0173:
Studies of States with Resistance to Vitamin D and Parathyroid Hormone

* 89-DK-0152:
Determination of Glomerular Filtration Rate, Effective Renal Plasma Flow and Glomerular Capillary Wall Permselectivity

* 87-DK-0029:
Diagnosis and Treatment of Patients with Cystic Fibrosis and Other Disorders of the Respiratory System and Pancreas

* 85-DK-0082:
Acromegaly Treatment and Natural History

* 77-DK-0096:
Studies on Thyroid Nodules and Thyroid Cancer

* 77-DK-0002:
Evaluation of Patients with Thyroid Function Disorders

* 76-DK-0006:
Studies of Molecular Genetics of Insulin Secretion, Insulin Action, and Diabetes Mellitus

Active Follow-up, Protocols NOT Recruiting New Patients 

* 04-DK-0193:
Identification and Mechanistic Investigations of Tolerant Kidney Transplant Patients

* 04-DK-0099:
Depletional Induction with Rabbit Anti-Thymocyte Globulin, Followed by Two Approaches Toward Monotherapy Immunosuppression in Kidney Transplant Recipients

* 04-DK-0057:
Renal Transplantation in Recipients with Nephropathic Cystinosis

* 03-DK-0245:
Effect of AC2993 (Synthetic Exendin-4) - Administered Alone or in Combination with Daclizumab - On Islet Function in Patients with Type I Diabetes

* 03-DK-0212:
Long-Term Treatment of Nonalcoholic Steatohepatitis With Pioglitazone

* 03-DK-0136:
Low Dose Peginterferon and Ribavirin Therapy for Patients with Chronic Hepatitis C Infected with Genotype 2 or 3

* 03-DK-0132:
The Pathogenesis of Chronic Graft Failure after Kidney Transplantation

* 03-DK-0071:
Sirolimus Therapy in Idiopathic and Lupus Membranous Nephropathy

* 02-DK-0065:
Combination of Pegylated Interferon and Ribavirin as Therapy for Patients with Chronic Hepatitis C with and without Renal Disease

* 01-DK-0249:
Ingested Interferon-Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

* 01-DK-0246:
Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

* 01-DK-0036:
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

* 00-DK-0196:
Sirolimus Monotherapy to Optimize Activation Induced Cell Death (AICD) in Renal Transplants Following Lymphocyte Depletion Induction with Thymoglobulin

* 00-DK-0186:
The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon Therap

* 00-DK-0042:
Pirfenidone in Focal Segmental Glomerulosclerosis:Phase II Study

* 99-DK-0120:
Screening Protocol for Patients Needing a Kidney, Kidney-Pancreas, or Islet Cell Transplant

* 99-DK-0107:
Live Donor Renal Donation for Allotransplantation

* 92-DK-0033:
Pharmacokinetics and Biodistribution of Ascorbic Acid in Healthy Human Subjects

* 90-DK-0137:
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome

* 76-DK-0081:
Studies with 1,25-Dihydroxycholecalciferol

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