National Heart, Lung and Blood Institute (NHLBI)

132 Protocols (83 Active Accrual of new subjects, 49 Follow-up of previously enrolled subjects)

 09-H-0062:

Collection of Blood and Bone Marrow Samples from Select Patients with CML to Measure Minimal Residual Disease

 08-H-0222:

Neuropsychological Effects of Immunosuppressive Treatment in Subjects with Aplastic Anemia

 08-H-0186:

Safety and the Anti- Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK-TRAIL Cytotoxicity with Bortezomib

 08-H-0185:

Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Normal Volunteers

 08-H-0177:

Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus Trial (The MILES Trial)

 08-H-0156:

Screening of Subjects to Determine Eligibility to Safely Participate in Blood Disorders Studies

 08-H-0108:

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

 08-H-0084:

Evaluation of Systemic Toxicity Associated with Allogeneic Peripheral Blood Stem Cell Infusion

 08-H-0081:

Identification of Biomarkers in Exhaled Breath Condensates from Asthmatic Patients

 08-H-0067:

Ciliary Dysfunction as an Underlying Etiology Linking Primary Ciliary Dyskinesia with Heterotaxy and Complex Congenital Heart Disease

 08-H-0047:

A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Allergic Asthma

 08-H-0046:

Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

 08-H-0028:

Pilot Study of Monocyte Biology in Insulin Sensitive, Resistant and Diabetic Subjects

 08-H-0016:

Effect of Fasting on the Size of Lymphangioleiomyomas in Patients with Lymphangioleiomyomatosis

 07-H-0225:

A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients with RAEB-1 AND RAEB-2 Myelodysplastic Syndrome (MDS) and AML with Trisomy 8

 07-H-0196:

Niacin Therapy to Improve Endothelial Function in Sickle Cell Disease

 07-H-0177:

Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy

 07-H-0159:

Efficacy of WT1 and PRI Peptide Vaccination for Patients with Low Risk Myeloid Malignancies

 07-H-0157:

Suburban/NHLBI Cardiovascular Disease Screening Protocol

 07-H-0136:

Selective Depletion of Alloreacting T Cells Using a Photodepletion Technique to Prevent GVHD after HLA-Matched Peripheral Blood Stem Cell Transplantation for Subjects with Hematologic Malignancies

 07-H-0113:

Collection of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers

 07-H-0104:

A Phase II Study of Lenalidomide Revlimid® (Registered Trademark) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

 07-H-0091:

WTI Peptide Vaccination for Patients with High Risk Hematological Malignancies

 07-H-0056:

Validation of Cardiac MR Perfusion with Cardiac Catheterization Physiological Assessment

 07-H-0030:

Metabolic Regulation by Tumor Suppressor p53 in Li-Fraumeni Syndrome

 07-H-0005:

Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease

 06-H-0249:

Magnetic Resonance Angiography (MRA) in the Diagnosis of Atherosclerotic Disease Using High Field (3T) MRI Scanners: A Pilot Technical Development Study

 06-H-0248:

Peripheral Blood Stem Cell Allotransplantation for Hematological Malignancies Using a Positive Stem Cell Selection Technique for T Cell Depletion, Followed by Delayed T Cell Add-Back

 06-H-0228:

A Pilot Study of Fractionated Dose Subcutaneous Rituximab (RTX, Rituxan® (Registered Trademark)) in Patients with Refractory or Relapsed Chronic Lymphocytic Leukemia

 06-H-0222:

Role of Helicobacter Pylori and Its Toxins in Pulmonary and Oropharyngeal Disease

 06-H-0208:

Cardiovascular Magnetic Resonance Imaging of Pediatric Normal Volunteers

 06-H-0203:

Catheter-Based Treatment of Cardiovascular Disease in Patients

 06-H-0202:

Cardiopulmonary Function Assessment and NO Based Therapies for Patients with Hemolysis-Associated Pulmonary Hypertension

 06-H-0190:

Treatment of T-Large Granular Lymphocyte (T-LGL) Lymphoproliferative Disorders with Alemtuzumab (Campath)

 06-H-0168:

An Open-Label, Baseline-Controlled Study of the Safety and Efficacy of SeeMore (EVP 1001-1 Injection) in Heart Patients

 06-H-0165:

Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension

 06-H-0156:

A Pilot Study of the Safety and Activity of Escalating Doses of AMD3100 to Mobilize CD34+ Cells in Healthy Volunteers

 06-H-0072:

Atorvastatin as a Disease Modifying Agent in Stage II and III Pulmonary Sarcoidosis: A Randomized, Double-Blind, Placebo-Controlled Trial

 06-H-0034:

A Randomized Study of Three Immunosuppressive Regimens in Treatment Naive Patients with Severe Aplastic Anemia: Horse-ATG/CsA Taper vs Rabbit-ATG/CsA vs Alemtuzumab

 05-H-0244:

A Pilot Study of Recombinant Humanized Anti-CD20 Antibody (Rituximab) in Patients with Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia

 05-H-0242:

A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic Anemia

 05-H-0206:

A Pilot Study of Alemtuzumab (Campath[R]) in Patients with Myelodysplastic Syndrome (MDS)

 05-H-0130:

Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants

 05-H-0019:

A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

 04-H-0202:

Human Diseases with Mutation of Non-Muscle Myosin Heavy Chain Genes

 04-H-0161:

Studies of the Natural History of Sickle Cell Disease and Other Hemolytic Disorders

 04-H-0078:

Peripheral Blood Hematopoietic Progenitor Cell Mobilization with AMD 3100 in Healthy Volunteers Previously Mobilized with G-CSF

 04-H-0012:

Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

 03-H-0280:

Disease Pathogenesis and Natural History of Lipid Disorders

 03-H-0250:

Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging

 03-H-0249:

A Randomized Trial of Immunosupression in Aplastic Anemia Patients with Refractory Pancytopenia or Suboptimal Hematologic Response After h-ATG/CsA Treatment

 03-H-0170:

Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Anemia, Thalassemia, and Diamond Blackfan Anemia

 03-H-0168:

Peripheral Blood Granulocyte Mobilization and Gene Expression Profiling in Adult Individuals of African Descent, With and Without Benign Ethnic Neutropenia

 03-H-0105:

The Determination Of Genetic Basis Of Immunodeficiency

 03-H-0051:

Collection of Blood, Stool, Bone Marrow and/or Tissue Samples from Subjects with Hepatitis-Associated Aplastic Anemia

 02-H-0250:

A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H

 02-H-0160:

Peripheral Blood Stem Cell Collection from Adult Volunteers

 02-H-0050:

Technical Development of Cardiovascular Magnetic Resonance Imaging

 01-H-0198:

Clinical Course in Cystic Fibrosis: The Effects of Pseudomonas Aeruginosa and Potential Modifier Genes

 01-H-0122:

Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy

 01-H-0088:

Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia

 00-H-0051:

Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis

 00-H-0029:

A Pilot Study of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) in Patients with Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia

 99-H-0076:

Fiberoptic Bronchoscopy in Patients with Asthma

 99-H-0050:

Non-myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic Diseases

 99-H-0048:

Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

 99-H-0037:

Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease

 98-H-0062:

Role of Exotoxins in the Pathogenesis of Pseudomonas Aeruginosa

 97-H-0204:

Cardiovascular Magnetic Resonance Imaging

 97-H-0196:

A Phase II Study of HLA-Matched Peripheral Blood Stem Cell Transplantation for Metastatic Renal Cell Carcinoma as Adoptive Allogeneic Immunotherapy

 97-H-0154:

High-Dose Cyclophosphamide with CD34+ Selected Autologous Hematopoietic Cell Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia

 97-H-0061:

Evaluation and Treatment of Pulmonary Patients not Participating in Research (Training Protocol)

 97-H-0041:

Screening Protocol for Subjects Being Evaluated for Hematology Branch Protocols

 97-H-0026:

Magnetic Resonance at 1.5 and 3 Tesla

 97-H-0022:

Segmental Bronchoalveolar Lavage

 96-H-0100:

Role of Genetic Factors in the Pathogenesis of Lung Disease

 96-H-0049:

Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Normal Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic Transplantation

 95-H-0186:

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

 95-H-0047:

Evaluation of Patients with Heart Disease Not Eligible for Research Protocols

 94-H-0010:

Evaluation, Treatment and Training Protocol for Patients with Bone Marrow Failure States, Isolated or Multilineage Cytopenias, Metastatic Solid Tumors, or Hematologic Malignancies

 82-H-0032:

Comprehensive Evaluation of the Etiology and Pathogenesis of Chronic Lung Disease (Screening Protocol)

 79-H-0100:

Teaching Protocol for the Evaluation of Plasma Lipoproteins

 76-H-0051:

Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients

 08-H-0210:

Long Term Follow Up of Children and Adolescents Diagnosed with Hypertrophic Cardiomyopathy: Identification of Risk Factors that Predict Arrhythmia Events

 07-H-0186:

Genes Causing Congenital Ebstein's Anomaly

 07-H-0124:

Pilot Study for the Development of Transient Forearm Endothelial Dysfunction

 07-H-0055:

Effects of Interleukin-1 Inhibition on C-Reactive Protein Levels, Endothelial Progenitor Cell Mobilization and Endothelial Function in Patients with Coronary Artery Disease

 06-H-0220:

Long-Term, Open-Label, Multicenter, Extension Study of Bosentan in Patients with Pulmonary Hypertension Associated with Sickle Cell Disease Completing a Double-Blind ASSET Study (AC-052-368 or AC 052-369)

 06-H-0124:

Randomized, Placebo-Controlled, Double-Blind, Multicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Bosentan in Patients with Symptomatic Pulmonary Hypertension Associated with Sickle Cell Disease (ASSET 2)

 06-H-0123:

Randomized, Placebo-Controlled, Double-Blind, Multicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Bosentan in Patients with Symptomatic Pulmonary Arterial Hypertension Associated with Sickle Cell Disease (ASSET 1)

 06-H-0122:

Mechanism and Vascular Effects of Endothelial Progenitor Cell Mobilization in Patients with Coronary Artery Disease Undergoing Cardiac Rehabilitation

 06-H-0082:

Telomere Repair Gene Mutations in Inflammatory Bowel Disease

 06-H-0062:

Safety of WT1 and PR1 Peptide Vaccination for Patients with Myeloid Malignancies

 06-H-0054:

Evaluation of Synergy of Combining Hydroxyurea with Recombinant Human Erythropoietin Glycoform Alpha (rhu Erythropoietin-alpha) on Fetal Hemoglobin Synthesis in Patients with Sickle Cell Anemia

 06-H-0018:

Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force: The NHLBI "Keep the Beat" Program

 05-H-0243:

A Phase I, Open-Label, Multiple-Center, Single-Dose, Dose-Escalating, Safety, Tolerability, Immunogenicity, Pharmacokinetic and Pharmacodynamic Study of GMA161 in Patients with Idiopathic Thrombocytopenic Purpura (ITP)

 05-H-0163:

Relationship of Diastolic Function and Functional Capacity in Hypertrophic Cardiomyopathy: a Post-Hoc Analysis of Protocols 01-H-0066 and 96-H-0144

 05-H-0145:

Nitrite as a Marker of Cardiovascular Risk; Development of Novel Biomarkers in Patients with Coronary Artery Disease

 05-H-0114:

Evaluation of Systemic Nitrite Infusion and Its Effect on Exercise Physiology and Metabolism

 05-H-0088:

Evaluation of the Mechanism of NO Formation and Pharmacokinetics of Systemic Nitrite Infusion

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