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| Stephen Robert Ikeda, M.D., Ph.D., Senior Investigator |
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Stephen R. Ikeda received his B.S. in Chemistry and Zoology from the George Washington University. He received his M.D. and Ph.D. from the University of Maryland School of Medicine in 1980 and 1983, respectively, where he worked under the direction of Dr. Edson X. Albuquerque on the pharmacology of neuromuscular transmission. Dr. Ikeda did postdoctoral work at the NIH in the laboratory of Dr. Forrest F. Weight in the NIAAA. Work during this time his work focused on the biophysical properties and modulation of neuronal voltage-gated ion channels. Following postdoctoral training, he joined the Department of Pharmacology and Toxicology at the Medical College of Georgia, Augusta, GA, advancing to the rank of tenured Associate Professor before joining the Guthrie Research Institute in Sayre, PA as a Senior Scientist and Director of the Laboratory of Molecular Physiology. At Guthrie, Dr. Ikeda also served as Director of the Guthrie cDNA Resource Center and held an adjunct appointment as Research Professor of Pharmacology, SUNY Upstate Medical Center, Syracuse, New York. He returned to the NIAAA in 2002 as a Senior Investigator and Chief of the Laboratory of Molecular Physiology. Dr. Ikeda's current research focuses on the molecular mechanisms underlying signaling pathways linking G-protein coupled receptors to neuronal voltage-gated ion channels.
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Selected Recent Publications:
Guo, J. and Ikeda, S.R. (2004) Endocannabinoids modulate N-type calcium channels and G-protein coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons, Mol. Pharmacol In Press.
Ikeda, S.R. (2004) Expression of G protein signaling components in adult mammalian neurons by microinjection, Methods in Molecular Biology Volume 259: Receptor Signal Transduction Protocols 2nd ed. , 167�181.
Ward, Y., Spinelli, B., Quon, M.J., Chen, H., Ikeda, S.R. and Kelly, K. (2004) Phosphorylation of critical serine residues in Gem separates cytoskeletal functions from down-regulation of calcium channel activity, Mol. Cell. Biol 24, 651�661.
Kammermeier, P.J. and Ikeda, S.R. (2003) Specificity of metabotropic glutamate receptor 2 coupling to G proteins, Mol. Pharmacol 63, 183�191.
Ruiz-Velasco, V. and Ikeda, S.R. (2003) A splice variant of the G protein ��3-subunit implicated in disease states does not modulation ion channels, Physiol. Genomics 13, 85-95.
Ikeda, S.R. and Kammermeier, P.J. (2002) M-current mystery messenger revealed? , Neuron 35, 411�412.
Gr�newald, S., Schupp, B.J., Ikeda, S.R., Kuner, R., Steigerwald, F., Kornau, H.-C., and K�hr ,G. (2002) Importance of the GABAB receptor C-termini for G-protein coupling, Mol. Pharmacol 61, 1070�1080.
All Selected Publications
Contact Information:
Dr. Stephen Robert Ikeda
Laboratory of Molecular Physiology, NIAAA
Park Building, Room 150
12420 Parklawn Drive, MSC 8115
Bethesda, MD 20892-8115
Telephone: (301) 443-2807 (office),
(301) 443-2807 (laboratory),
(301) 480-1734 (fax)
Email: sikeda@mail.nih.gov
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