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| Francis J. McMahon, M.D., Investigator |
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Dr. McMahon received his B.A. in Biology from the University of Pennsylvania in 1982 and his M.D. from Johns Hopkins University School of Medicine in 1987. He stayed on at Hopkins to complete a medical internship, a residency in adult psychiatry, and a post-doctoral fellowship in psychiatric genetics before joining the faculty in 1993. In 1998, he became Associate Professor of Psychiatry and medical director of the Electroconvulsive Therapy Clinic at the University of Chicago. In 2002, he joined the Mood and Anxiety Disorders Program as chief of its Genetics Unit. Recently, Dr. McMahon was named a Mallinckrodt Scholar by the Edward F. Mallinckrodt Foundation. He also serves as a scientific advisor for the National Tourette Syndrome Association, the University of Antwerp, the RIKEN Brain Science Institute, and numerous scientific journals. Current research priorities include fine-mapping bipolar disorder susceptibility loci on chromosomes 6q, 13q, 18q, and 22q; identification of clinical features that define highly familial clinical subtypes of mood disorders; and the elucidation of parent-of-origin effects in the familial transmission of mood disorders.
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Staff:
- Nirmala Akula, M.A., Senior Research Assistant akulan@intra.nimh.nih.gov
- Silvia Buervenich, Ph.D., Postdoctoral Fellow BuervenS@intra.nimh.nih.gov
- Imer Cardona, B.A., Predoctoral Fellow cardonai@intra.nimh.nih.gov
- Leatha Chase-Jones, Secretary ChaseJoL@intra.nimh.nih.gov
- Winston Corona, M.A., Research Assistant coronaw@intra.nimh.nih.gov
- Sevilla Detera-Wadleigh, Ph.D., Staff Scientist DeteraS@intra.nimh.nih.gov
- Snyder Erin, B.A., Predoctoral Fellow syndere@intra.nimh.nih.gov
- Layla Kassem, Ph.D., Senior Research Fellow kassemL@intra.nimh.nih.gov
- Diane Kazuba, Patient Coordinator KazubaD@INTRA.NIMH.nih.gov
- Victor Lopez, M.D., Postdoctoral Fellow victorlopez@intra.nimh.nih.gov
- Jo Steele, M.A., Database Administrator steeleJ@intra.nimh.nih.gov
Research Interests:
Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.
We are recruiting families with multiple cases of mood disorder for use in genetic mapping studies. Volunteers are asked to provide a blood sample and undergo a psychiatric interview, usually over the telephone.
Current research priorities include genome-wide linkage mapping of bipolar susceptibility genes, fine-mapping bipolar disorder susceptibility loci on chromosomes 6q, 13q, 18q, and 22q; identification of clinical features that define highly familial clinical subtypes of mood disorders; the elucidation of parent-of-origin effects in the familial transmission of mood disorders; and candidate gene studies of the serotonin transporter, glucocorticoid receptor, and nuclear receptor genes. We also study patterns of linkage disequilibrium and "haplotype blocks" in the human genome.
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Clinical Protocols:
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Bipolar Disorder Genetics: A Collaborative Study (
80-M-0083 )
Selected Recent Publications:
Chen YS Akula N Detera-Wadleigh SD Schulze TG Thomas J Potash JB DePaulo JR McInnis MG Cox NJ McMahon FJ (2004) Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. , Mol Psychiatry 9 , 87-92 .
Full Text/Abstract
Schulze TG Zhang K Chen YS Akula N Sun F McMahon FJ (2003) Defining haplotype blocks and tag SNPs in the human genome: methods, allele frequencies, and parameters. , Hum Mol Genet , .
Full Text/Abstract
Schulze TG McMahon FJ (2003) Genetic linkage and association studies in bipolar affective disorder: a time for optimism. , Am J Med Genet 123C , 36-47 .
Full Text/Abstract
Schulze TG Chen YS Badner JA McInnis MG DePaulo JR McMahon FJ (2003) Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22., Biol Psychiatry 53, 239-43.
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McMahon FJ Simpson SG McInnis MG Badner JA MacKinnon DF DePaulo JR (2001) Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder., Arch Gen Psychiatry 58, 1025-31.
Full Text/Abstract
All Selected Publications
Contact Information:
Dr. Francis J. McMahon
Genetic Basis of Mood and Anxiety Disorders Unit, NIMH
Porter Neuroscience Research Center
Building 35, Room 1A-202
35 Convent Dr, MSC 3719
Bethesda, MD 20892-3719
Telephone: (301) 451-4455 (office),
(301) 451-4453 (laboratory),
(301) 402-7094 (fax)
Email: mcmahonf@intra.nimh.nih.gov
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