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| David C. Klein, Ph.D., Senior Investigator |
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Dr. Klein received his B.S. in Zoology from Cornell University and then worked in the Department of Biophysical Cytology at the Rockefeller University with Beatrice Magdoff. He received his Ph.D. in Biology from Rice University in 1968, where he investigated the effects of thyrocalcitonin on bone metabolism with Roy Talmadge. As a postdoctoral fellow in the Pharmacology Department of the University of Rochester School of Medicine, Dr. Klein studied the effects of prostaglandins on bone and began his career as a neuroendocrinologist, concentrating on the pineal gland. He moved to NICHD as a Staff Fellow in 1969 where he showed that serotonin N-acetyltransferase is the key enzyme controlling melatonin production. Dr. Klein received the G.J. Mendel Medal from the Czech Academy of Sciences in 1995. His laboratory, together with NIDDK collaborators, recently solved the structure of the serotonin N-acetyltransferase:14-3-3 regulatory complex and they are studying how this molecular complex controls the activity and stability of the enzyme.
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Staff:
- Dr. Diego Bustos, Ph.D., Postdoctoral Fellow, (301) 496-8423 bustosdi@mail.nih.gov
- Dr. Sam Clokie, Ph.D., Postdoctoral Fellow, (301) 451-6623 clokiesam@mail.nih.gov
- Dr. Steven Laurent Coon, Ph.D., Staff Scientist, (301) 496-8423 coons@mail.nih.gov
- Dr. Jong So Kim, Ph.D., Postdoctoral Fellow, (301) 496-8423 KIMJS@MAIL.NIH.GOV
- Dr. Ayran Namboodiri, Ph.D., Adjunct Investigator, (301) 496-8423 anamboodiri@usuhs.mil
- Dr. Jiri Pavlicek, Ph.D., Postdoctoral Fellow, (301) 496-8423 pavlicej@mail.nih.gov
- Ms. Joan L. Weller, B.A., Senior Research Assistant, (301) 496-8423 wellerj@mail.nih.gov
Research Interests:
The Section on Neuroendocrinology studies molecular aspects of neural regulation, and uses the pineal gland as a model. This is a multidisciplinary program that probes the fundamental issues of mechanisms involved in the development of differentiated cells and neural control of daily changes in metabolism. The techniques used that range from protein crystallography to gene profiling to conditional gene deletion
NES Website:http://eclipse.nichd.nih.gov/nichd/ldn/SNE/index.htm
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Contact Information:
Dr. David C. Klein
Chief, Section on Neuroendocrinology
Office of Scientific Director
National Institute of Child Health and Human Development
National Institutes of Health
49 Convent Drive Room 6A82
Bethesda, MD 20892-4480
Telephone: (301) 496-6915 (office),
(301) 480-3526 (fax)
Email: kleind@mail.nih.gov
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