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| Konrad Noben-Trauth, Ph.D., Senior Investigator |
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Dr. Noben-Trauth received his Diploma in Biology from the University of Heidelberg in 1990. He was awarded a Heidelberg Scholarship to study at University of Lexington, Kentucky, where he worked with Thomas Roszman on the function of beta-adrenergic receptors on human lymphocytes. He obtained his Ph.D. in 1994 from University of Freiburg where he performed research with Karl-Heinz Klempnauer at the Max-Planck-Institute for Immunobiology on myb transcription factors. He carried out postdoctoral research in the group of Patsy Nishina and Jurgen Naggert at The Jackson Laboratory, Bar Harbor, Maine, studying the genetics of neurosensory systems and modifiers (tub and dfw). He joined NIDCD in 1997 and became a Senior Investigator in 2004. His laboratory clones and studies genes, modifiers and QTLs aimed to dissect and understand genetic networks and pathways essential for hearing.
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Staff:
Research Interests:
The Section on Neurogenetics studies the molecular genetics of the mouse cochlea. In particular, we interested in identifying genetic networks and molecular pathways that control hearing in the young, adult and aging cochlea. Combinations of QTL mapping, positional cloning, micro-array analyses, proteomics, and different mouse genetic resources such as inbred, outbred, congenic and recombinant inbred strains are being used. A second area studies the function of the Trpml3 ion channel, the gene mutated in the Jackson circler mouse, and other interesting spontaneous mouse mutations affecting hearing.
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Selected Recent Publications:
Kenneth R. Johnson, Yin Q. Zheng and Konrad Noben-Trauth (2006) Strain Background Effects and Genetic Modifiers of Hearing in Mice., Brain Research 1091, 79-88.
Meghan Drayton and Konrad Noben-Trauth (2006) Mapping quantitative trait loci for hearing loss in Black Swiss mice., Hearing Research 212, 128-139.
Alfredo Calderon, Adam Derr, Barden B. Stagner, Kenneth R. Johnson, Glen Martin, and Konrad Noben-Trauth (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse, Hearing Research, In Press.
Agnieszka K. Rzadzinska, Adam Derr, Bechara Kachar and Konrad Noben-Trauth (2005) Sustained cadherin 23 expression in young and adult cochlea of normal and hearing impaired mice, Hearing Research 208, 114-121.
Kenneth R. Johnson, Qing Yin Zheng, Michael D. Weston, Louis J. Ptacek, and Konrad Noben-Trauth (2005) The Mass1Frings mutation underlies early-onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome type 2C, Genomics 85, 582-590.
Konrad Noben-Trauth, Qing Y. Zheng, and Kenneth R. Johnson (2003) Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss, Nature Genetics 35, 21-23.
All Selected Publications
Contact Information:
Dr. Konrad Noben-Trauth
Neurogenetics Section
Laboratory of Molecular Biology, NIDCD
5 Research Court
Rockville, MD 20850-
Telephone: (301) 402-4223 (office),
(301) 402-4223 (laboratory),
(301) 435-4040 (fax)
Email: nobentk@nidcd.nih.gov
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