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| Jacqueline N. Crawley, Ph.D., Senior Investigator |
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Dr. Crawley received her B.A. degree from the University of Pennsylvania in 1971. She obtained her Ph.D. from the University of Maryland in 1976, where she studied catecholamines mediating isolation-induced aggression in male mice. Dr. Crawley did postdoctoral training at Yale University with James Maas and Robert Roth, investigating neuropharmacological activation of the locus coeruleus, using gas chromatography-mass spectrometry to measure catecholamine metabolites in brain and plasma of rats. In 1979 she came to the NIMH as a PRAT Fellow and studied anxiety-like behaviors in mice. Dr. Crawley spent several years at the Neurobiology Basic Research Program at DuPont before returning to NIMH in 1983 to create a rodent behavioral neuropharmacology laboratory. She served as Acting Deputy Scientific Director of NIMH (1993), President of the International Behavioral Neuroscience Society (2000-2001), Organizer of the Summer Neuropeptide Conference (1993-98), and Editor of the journal Neuropeptides (1997-present). In 2005 Dr. Crawley was awarded the International Behavioral Neuroscience Society, Marjorie A. Myers Lifetime Achievement Award for outstanding scientific contributions to the field of behavioral neuroscience and the International Behavioral Neuroscience Society Fleur Strand Award for outstanding research on neuropeptides and behavior. Dr. Crawley�s laboratory is studying the role of the neuropeptide galanin in learning and memory, and its potential involvement in Alzheimers disease.
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Staff:
- Charlotte Barkan, Post baccalaureate Fellow, (301) 451-9389 barkanc@mail.nih.gov
- Kathryn Chadman, Ph.D., Postdoctoral Fellow, (301) 451-4843 chadmank@mail.nih.gov
- Jill Silverman, Ph.D., Laboratory Manager, (301) 451-9388 silvermanj@mail.nih.gov
- Mu Yang, Ph.D., Postdoctoral Fellow, (301) 451-9387 yangmu@mail.nih.gov
Research Interests:
Modeling the symptoms of autism in mice, including social interaction, communication, and repetitive behaviors; behavioral phenotyping of mice with targeted mutations in candidate genes for autism; testing drug treatments and environmental interventions for reversal and prevention of autism-like endophenotypes in mouse models.
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Selected Recent Publications:
McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN (InPress) Autism-like behavioral phenotypes in BTBR T+tf/J mice, Genes, Brain and Behavior.
Chadman KK, Gong S, Scattoni ML, Boltuck SE, Gandhy SU, Heintz N, Crawley JN (2008) Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice., Autism Research in press.
McFarlane HG, Kusek GK, Yang M, Phoenix JL, Bolivar VJ, Crawley JN (2008) Autism-like behavioral phenotypes in BTBR T+tf/J mice, Genes, Brain and Behavior 7, 152-163.
Crawley JN, Chen T, Puri A, Sullivan TL, Hill JM, Young NB, Nadler JJ, Moy SS, Young LJ, Caldwell J, Young WS (2007) Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments, Neuropeptides 41, 145-163.
Bailey KR, Pavlova MN, Rohde AD, Hohmann JG, Crawley JN (2007) Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze, Pharmacology Biochemistry and Behavior 86, 8-20.
Ricceri L, Moles A, Crawley J (2007) Behavioral phenotyping of mouse models of neurodevelopmental disorders: Relevant social behavior patterns across the life span, Behavioural Brain Research, Special Issue on Animal Models of Autism 176, 40-52.
Crawley JN, Chen T, Puri A, Sullivan TL, Hill JM, Young NB, Nadler JJ, Moy SS, Young LJ, Caldwell J, Young WS (2007) Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments, Neuropeptides 41, 145-163.
All Selected Publications
Contact Information:
Dr. Jacqueline N. Crawley
Laboratory of Behavioral Neuroscience, NIMH
Porter Neuroscience Research Center
Building 35, Room 1C-903
35 Convent Drive
Bethesda, MD 20892-3730
Telephone: (301) 496-7855 (office),
(301) 480-4630 (fax)
Email: crawleyj@intra.nimh.nih.gov
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