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Click to Watch TARPs and KARPs: Auxiliary Proteins that Modulate AMPA- and Kainate-receptor Kinetics

Dr. James Howe did postdoctoral training with Stuart Cull-Candy and David Colquhoun at University College London before moving to Yale to work with Murdoch Ritchie where he is currently Professor of Pharmacology. Dr. Howe's research on the glutamate receptor ion channels which mediate synaptic transmission in the brain uses biophysical approaches to explore their mechanism of action. Most recently he has worked on how TARPS modulate AMPA receptor function and will present new work on a second family of modulatory proteins for kainate receptors.

Selected Publications:

Robert, A., Armstrong, N., Gouaux, J.E., and Howe, J.R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25:3752-3762.

Tomita, S., et al. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435:1052-1058.

For more information - NIH Neuroscience Seminar Series

Monday, January 12, 2009 12:00:00 PM EST (-0500)

James Howe, Ph.D., Department of Pharmacology, Yale University School of Medicine

Runtime 75 minutes

Later Today

Measuring Diet and Physical Activity - with Cell Phones, Digital Imaging, and Wearable Monitors (NIH Only)

NIH Obesity Research Task Force Seminar Series

This seminar will feature presentations on: “Improving dietary assessment methods using cell phones and digital imaging,” by Dr. Carol Boushey, Purdue University; and “A new approach in objective measurement of physical activity using wearable monitors,” by Dr. Patty Freedson, University of Massachusetts.

Monday, January 12, 2009 3:30:00 PM EST (-0500)

Dr. Carol Boushey, Purdue University and Dr. Patty Freedson, University of Massachusetts

Runtime 90 minutes