[Federal Register: August 7, 2001 (Volume 66, Number 152)]
[Notices]
[Page 41254]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr07au01-104]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, DHHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by agencies of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
Amine Modified Random Primers for Microarray Detection
Dr. Charles Xiang and Dr. Michael J. Brownstein (NIMH), DHHS Reference
No. E-098-01/0 filed 11 Apr 2001
Licensing Contact: Uri Reichman; 301/496-7736 ext. 240; e-mail:
reichmau@od.nih.gov.
DNA Microarray technology has become one of the most important
tools for high throughput studies in medical research, with
applications in the areas of gene discovery, gene expression and
mapping, and drug discovery. The technology requires the use of
detection probes (cDNA probes, usually fluorescent) which are commonly
made from single nucleotides using a template polynucleotide, such as
mRNA. The standard methods of making cDNA probes suffer from problems
related to reproducibility, and they generally result in poor
incorporation of the fluorescent dye and in low sensitivity. The
present invention relates to a new method for preparing cDNA probes.
The new method overcomes the common problems exhibited by existing
methods. The method utilizes amine modified random primers rather than
single nucleotides, and results in highly efficient incorporation of
the fluorescent dye in multiple sites in the probe. Coupling of the
fluorescent dye to the amine residues is performed after the synthesis
of the cDNA by reverse transcription. This novel procedure requires
significantly less RNA than standard techniques. Licensees of the
invention will be provided with primers and other reagents required to
practice the invention.
Net-Trials--Clinical Trials Information System
Douglas Hageman, Dianne M. Reeves (NCI), DHHS Reference No. E-164-01/0
Licensing Contact: Dale Berkley; 301/496-7735 ext. 223; e-mail:
berkleyd@od.nih.gov.
The invention is a software-based application that supports data
collection, reporting, validation and quality assurance for clinical
data, where the data comprise clinical observations, patient histories,
physical examinations and laboratory tests and procedures. This
software is a Java based application with accompanying database that
could be offered via an Internet browser to registered users. The
invention is intended to offer health care sites and centers that are
conducting clinical research an integrated software application for
patient, protocol, and research data management in a single
application.
Method to Fabricate Continuous Lengths of Helical Coiled Shape
Memory Wire
Theodor Kolobow (NHLBI), DHHS Reference No. E-105-00/0 filed 29 Sep
2000
Licensing Contact: Dale Berkley; 301/496-7735 ext. 223; e-mail:
berkleyd@od.nih.gov.
The invention is a method and apparatus for fabricating and storing
continuous lengths of helical coil shaped memory wire for use in
springs, endotracheal tubes, medical stents and as reinforcement for
medical tubing (e.g. catheters). The helically coiled wire is
continuously formed from a special nickel-titanium wire and spooled for
storage in a straightened form. When the wire is later unspooled, it
will snap back into the desired helical coil form.
In one method of the invention, Nitinol wire is passed through a
spring forming unit to curve the wire. The so formed coil is then
loosely guided along a cylindrical mandrel, passed through a high
temperature oven so that the helical coil shape will be memorized, and
then uncoiled and stored in a straightened form. The method provides a
very thin wire with great strength and integrity of shape that resists
kinking or collapse in most medical applications.
Dated: July 27, 2001.
Jack Spiegel,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 01-19642 Filed 8-6-01; 8:45 am]
BILLING CODE 4140-01-P