WPC 2J BNLZTimes Roman#|]=]\  PCP"S^*8DSS888S^*8*.SSSSSSSSSS..^^^Jxooxf]xx8Axfxx]xo]fxxxxf8.8NS8JSJSJ8SS..S.SSSS8A.SSxSSJP!PZ8*888888888888S.xJxJxJxJxJooJfJfJfJfJ8.8.8.8.xSxSxSxSxSxSxSxSxSxSxJxSxSxSxS]SxJxJoJoJoJoJxSfJfJfJfJxSxSxSxSxSxS8S8S888SA8xSf.f8f8f.xSxSxSxSxSxo8o8o8]A]A]A]Af8f8xSxSxSxSxxSfJfJN:*LS8JSSSSS.4}}S2S}2JJS88SS]]8J2t^^\\^^ee*C^.wR)Ewn\1fy\r\S{v\rQMS PS 810QMPS810.PRS]\  PChhhhP26| L Z#|]aM"S^*8DSS888S^*8*.SSSSSSSSSS..^^^Jxooxf]xx8Axfxx]xo]fxxxxf8.8NS8JSJSJ8SS..S.SSSS8A.SSxSSJP!PZ8*888888888888S.xJxJxJxJxJooJfJfJfJfJ8.8.8.8.xSxSxSxSxSxSxSxSxSxSxJxSxSxSxS]SxJxJoJoJoJoJxSfJfJfJfJxSxSxSxSxSxS8S8S888SA8xSf.f8f8f.xSxSxSxSxSxo8o8o8]A]A]A]Af8f8xSxSxSxSxxSfJfJN:*LS8JSSSSS.4}}S2S}2JJS88SS]]8J2t^^\\^^ee*C^.wR)Ewn\1fy\r\S{v\rQMS PS 810QMPS810.PRS]\  PChhhhP2 LhELLE "S^*8]SS888S_*8*.SSSSSSSSSS88___SxoxxofASoxfx]oxxxxo8.8aS8S]J]J8S].8].]S]]JA8]SxSSJB%BW8*888888888888].xSxSxSxSxSxxJoJoJoJoJA.A.A.A.x]SSSSx]x]x]x]xSxSSSxSxSf]xSxSxJxJxJxJx]oJoJoJoJSSSSS]A]A]A8A]S8]o.o8o8o.x]x]x]SSxxJxJxJ]A]A]A]Ao8o8x]x]x]x]xxSoJoJN:*ZS8SSSSSS27}}S2}}S}2.SSS88SS]]8S2t__\\__ee*C_.wR)Ewn\1fy\r\]{v\rTimes RomanTimes Roman BoldTimes Roman ItalicCourierCourier Bold"S^*8FSS888Sq*8*.SSSSSSSSSS88qqqSffoxffxx8Jo]oxfxfS]xff]]A.AFS8SSJSJ.SS..J.xSSSSAA.SJoJJAC.CZ8*888888888888S.fSfSfSfSfSooJfJfJfJfJ8.8.8.8.oSxSxSxSxSxSxSxSxS]JfSxSxS]JxSfSfSfSoJoJoJoJxSfJfJfJfJxSxSxSxSxSxS8S8S888SJ8oJ].]8]8].oSoSoSxSxSofAfAfASASASASA]8]8xSxSxSxSo]J]A]AN:*WSASSSSSS.4}}S2S}2$]]S88SSSS8]2tqq\\qqee*Cq.wR)Ewn\1fy\r\S{v\r"S^!)22SN!!!28!2222222222888,\HCCH=8HH!'H=YHH8HC8=HH^HH=!!/2!,2,2,!222N2222!'22H22,006!!!d!!!!!!!!!!2H,H,H,H,H,YCC,=,=,=,=,!!!!H2H2H2H2H2H2H2H2H2H2H,H2H2H2H282H,H,C,C,C,C,H2=,=,=,=,H2H2H2H2H2H2!2!2!!!2'!H2==!=!=H2H2H2H2H2YHC!C!C!8'8'8'8'=!=!H2H2H2H2^HH2=,=,N#-2!,22222KK2LL2K,,2d!!22b88d!,dt887788c<6660"66X@K@g/ZZZ8dZ `K yO   #]\  PC=P#3_ TUESDAY 6  yO 6 .O September 8, 1992 6 6 6 6  yOx 6 d  6  yO 2 Part VIII 6   yO  Environmental Protection Agency  yO d  6  yO *% 40 CFR Parts 372 and 721  yO 6  Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Significant New Use  yO -Rule; Proposed Rule 6 6   {M (This reprint was prepared from the electronic file that accompanied the original signed documents transmitted to the Office of the Federal Register. This file was certified to be a true copy of the originals.)  yO  (This document appeared at 57 FR 41019-41046.) 0*((  {v yO  Federal Register / Vol. 57, No. 174/ Tuesday, September 8, 1992 / Proposed Rules d 6ԣd  yOX  ENVIRONMENTAL PROTECTION AGENCY   yO *% 40 CFR Parts 372 and 721 6  yO@ 6  [OPPTS - 400069; FRL - 4078 - 5]  yO  Chemicals; Toxic Chemical Release Reporting; Community Right-To-Know; Proposed Significant New Use 4FRule 6  yO 6  AGENCY: Environmental Protection Agency (EPA).  yO  ACTION: Proposed rule. d 6  yO0 6  SUMMARY: EPA is partially granting a petition submitted by Governor Mario M. Cuomo of New York and the Natural Resources Defense Council to add 80 chemicals and 2 chemical categories to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) by proposing to add 68 chemicals and 2 chemical categories. All of the chemicals and chemical categories contained in this petition appear on the Resource Conservation and Recovery Act (RCRA) list of hazardous wastes at 40 CFR 261.33(f). The addition of these chemicals and chemical categories to the list of toxic chemicals is based on their acute human health effects, carcinogenicity or other chronic human health effects, or their environmental effects. EPA believes that these chemicals and chemical categories meet the criteria for addition to the list of toxic substances as established in EPCRA section 313(d)(2). EPA is not proposing to add the remaining 12 chemicals addressed in this petition because the available data do not indicate that these chemicals meet the criteria of EPCRA section 313(d)(2). Alternatively, EPA is proposing to add only those chemicals identified in this document that are produced in quantities greater than a certain manufacturing threshold. The selection of an annual manufacturing volume threshold would be guided by the section 313(f) reporting thresholds, such that the addition of those chemicals produced in quantities less than the selected threshold would not be expected to result in the submission of EPCRA section 313 Form R reports to EPA. As discussed in Unit VI, EPA is requesting comment on the use of an annual manufacturing volume threshold and on what an appropriate threshold should be. In conjunction with this alternative proposal, the Agency is proposing a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) that would cover the substances manufactured or imported in amounts less than the selected manufacturing volume threshold specified in this Rule. This petition does not request that any action be taken under RCRA, and today's proposal should not be inferred as a proposed RCRA action or a request for comment on the RCRA list of hazardous wastes.  yO`"  DATES : Written comment on this proposed rule should be submitted by November 9, 1992. Submissions of TSCA section 14 CBI waivers should be submitted by November 9, 1992.  yO$  ADDRESSES: Written comments should be submitted in triplicate to: OPPT Docket Clerk, TSCA Public Docket Office, Environmental Protection Agency, TS - 793, Rm. NE - 004, 401 M St., SW., Washington, DC 20460, Attn: Docket Number OPPTS - 400069. Requests for TSCA section 14 waivers should be submitted to: TSCA Document Receipt Office (TS - 790), Office of Pollution Prevention and Toxics, Environmental Protection Agency, Rm. ET - 105, 401 M St., SW., Washington, DC 20460.'0*((Ԍ yO ԙ FOR FURTHER INFORMATION CONTACT: Maria J. Doa, Petitions Coordinator, Emergency Planning and Community Right-to-Know Information Hotline, Environmental Protection Agency, Mail Stop TS - 779, 401 M St., SW., Washington, DC 20460, Toll free: 800 - 535 - 0202.  yOX  SUPPLEMENTARY INFORMATION :  {O   Electronic Availability: This document is available as an electronic file on The Federal Bulletin Board the day of  yO publication in the Federal Register . By modem dial 202 - 512 - 1387 or call 202 - 512 - 1530 for disks or paper copies. This file is available in Postscript, Wordperfect 5.1 and ASCII.  yOB / I. Introduction 6  {M 6  A. Statutory Authority  {Ob  This proposal is issued under section 313(d) and (e) of the Emergency Planning and Community Right-to-Know Act of 1986 (42 U.S.C. 11023 et seq., ``EPCRA''). EPCRA is also referred to as Title III of the Superfund Amendments and Reauthorization Act (SARA) of 1986.  {M B. Background  {O  Section 313 of EPCRA requires certain facilities manufacturing, processing or otherwise using toxic chemicals to report their environmental releases of such chemicals annually. Beginning with the 1991 reporting year, such facilities also must report pollution prevention and recycling data for such chemicals, pursuant to section 6607 of the Pollution Prevention Act (42 U.S.C. 13101 et seq.). Section 313 establishes an initial list of toxic chemicals that is comprised of more than 300 chemicals and 20 chemical categories. Any person may petition EPA to add chemicals to or delete chemicals from the list (EPCRA section 313(e)). Under EPCRA section 313(e)(2), if a State Governor petitions EPA to add a chemical to the list, the chemical will be added within 180 days after receipt of the petition, unless the Administrator: (1) Initiates a rulemaking to add the chemical to the list, in accordance with section 313(d)(2); or (2) publishes an explanation of why the Administrator believes the petition does not meet the statutory requirements of section 313(d)(2) for adding a chemical to the list.  yO  EPA issued a statement of petition policy and guidance in the Federal Register of February 4, 1987 (52 FR 3479), to provide guidance regarding the recommended content and format for petitions. On May 23, 1991 (56 FR 23703), EPA published guidance regarding the recommended content of petitions to delete individual members of the section 313 metal compound categories.  yO )K II. Description of Petition 6  yO^ 6  On March 4, 1992, EPA received a petition from Governor Mario M. Cuomo of New York and the Natural Resources Defense Council to add 80 chemicals and 2 chemical categories to the list of toxic chemicals under section 313 of EPCRA. All of the chemicals and chemical categories appear on the RCRA list of toxic wastes under 40 CFR 261.33(f). The petitioners contend that the chemicals should be added to the EPCRA section 313 list because ``[t]he findings that must be made to add a chemical under [s]ection 313(d)(2)(B) are precisely the same findings that EPA has already made in the course of exercising its authority to identify and list hazardous wastes under RCRA.'' The statutory deadline for EPA's response is August 31, 1992.  yO! + III. Regulatory Status 6  yO.# 6  The 80 chemicals and 2 chemical categories are regulated under RCRA as hazardous wastes under 40 CFR.#0*$$ 261.33(f) and also appear as hazardous constituents listed in 40 CFR Part 261 Appendix VIII. The Appendix VIII list is comprised of chemicals which have toxic, carcinogenic, mutagenic, or teratogenic effects on human or other life forms (40 CFR 261.11(a)(3)). EPA uses this list as one criterion in determining whether a waste should be listed as hazardous under 40 CFR 261.11. In addition, there are other environmental statutes besides RCRA (see Table 1) under which these 80 chemicals and 2 chemical categories are regulated. For example, one of the chemicals, acetophenone, is listed as a Hazardous Air Pollutant under Title III of the Clean Air Act (CAA), as amended in 1990; 13 of the chemicals are listed on section 307(a) of the Clean Water Act (CWA) (the Priority Pollutant List) (see Table 1); 2 chemicals, 2,4,5-TP (silvex) and benzo[a]pyrene, are regulated under the Safe Drinking Water Act; all 82 chemicals and chemical categories are listed under section 102 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). Table 1 lists the chemicals and identifies their regulatory status under RCRA, CWA, and CERCLA. This petition does not request that any action be taken under any statute other than EPCRA, and today's proposal should not be inferred as a proposed action under any statute other than EPCRA or TSCA. Each statute prescribes different standards for adding or deleting chemicals or pollutants from their respective list. Today's proposal is based  yO solely on the criteria in EPCRA section 313. #dZ6X@K@# 3'3'Standard'3'3Standard810qaڰ  0*$$ TABLE 1--Chemicals and Chemical Categories Petitioned for Addition to EPCRA Section 313  RCRA U CERLA Section  g/  Chemical Name CAS No1. No.2 CWA Section 307(a)3 102(RQ)4   g/ Acetophenone 00098-86-2 u004 5,000 Acetyl chloride 00075-36-5 u006 5,000 Amitrole 00061-82-5 u011 10 Azaserine 00115-02-6 u015 1 Benz[c]acridine 00225-51-4 u016 100 Benz[a]anthracene 00056-55-3 u018 10 Benzo[rst]pentaphene 00189-55-9 u064 10 Benzo[a]phenanthrene 00218-01-9 u050 X 100 Benzo[a]pyrene 00050-32-8 u022 X 1 Bis(2-chloroethoxy)methane 00111-91-1 u024 X 1,000 4-Bromophenyl phenyl ether 00101-55-3 u030 X 100 Carbonic difluoride 00353-50-4 u033 1,000 Chloral 00075-87-6 u034 5,000 Chlorambucil 00305-03-3 u035 10 Chlornaphazine 00494-03-1 u026 100 p-Chloro-m-cresol 00059-50-7 u039 X 5,000 2-Chloroethyl vinyl ether 00110-75-8 u042 X 1,000 beta-Chloronaphthalene 00091-58-7 u047 X 5,000 4-Chloro-o-toluidine 03165-93-3 u049 100 hydrochloride Crotonaldehyde 04170-30-3 u053 100 Cyclophosphamide 00050-18-0 u058 10 Daunomycin 20830-81-3 u059 10 DDD 00072-54-8 u060 X 1 DDT 00050-29-3 u061 X 1 Dibenzo(a,h)anthracene 00053-70-3 u063 X 1 1,4-Dichloro-2-butene 00764-41-0 u074 1 1,2-Diethylhydrazine 01615-80-1 u086 10 O,O-Diethyl-S-methyl 03288-58-2 u087 5,000 dithiophosphate Diethylstilbestrol 00056-53-1 u089 1 Dihydrosafrole 00094-58-6 u090 10 7,12-Dimethylbenz[a]anthracene 00057-97-6 u094 1 1,2-Dimethylhydrazine 00540-73-8 u099 1 Ethylenebisdithiocarbamic NA u114 5,000 acids, salts and esters`xԌEthylidene dichloride 00075-34-3 u076 X 1,000 Ethyl methacrylate 00097-63-2 u118 1,000 Ethyl methanesulfonate 00062-50-0 u119 1 Fluoranthene 00206-44-0 u120 X 100 Formic acid 00064-18-6 u123 5,000 Glycidylaldehyde 00765-34-4 u126 10 Hexachlorophene 00070-30-4 u132 100 Hexachloropropene 01888-71-7 u243 1,000 Hydrogen sulfide 07783-06-4 u135 100 Indeno[1,2,3-cd]pyrene 00193-39-5 u137 X 100 Isobutyl alcohol 00078-83-1 u140 5,000 Kepone 00143-50-0 u142 1 Lasiocarpine 00303-34-4 u143 10 Maleic hydrazide 00123-33-1 u148 5,000 Malononitrile 00109-77-3 u149 1,000 Melphalan 00148-82-3 u150 1 Methacrylonitrile 00126-98-7 u152 1,000 Methapyrilene 00091-80-5 u155 5,000 Methyl chlorocarbonate 00079-22-1 u156 1,000 3-Methylcholanthrene 00056-49-5 u157 10 Methyl ethyl ketone peroxide 01338-23-4 u160 10 Methyl mercaptan 00074-93-1 u153 100 2-Methylpyridine 00109-06-8 u191 5,000 Methylthiouracil 00056-04-2 u164 10 Mitomycin C 00050-07-7 u010 10 MNNG (N-methyl-N'-nitro-N- 00070-25-7 u163 10 nitrosoguanidine) 1,4-Naphthoquinone 00130-15-4 u166 5,000 N-Nitrosodiethanolamine 01116-54-7 u173 1 N-Nitroso-N-methylurethane 00615-53-2 u178 1 N-Nitrosopyrrolidine 00930-55-2 u180 1 5-Nitro-o-toluidine 00099-55-8 u181 100 Paraldehyde 00123-63-7 u182 1,000 Pentachlorobenzene 00608-93-5 u183 10 Pentachloroethane 00076-01-7 u184 10 Phenacetin 00062-44-2 u187 100 Pronamide 23950-58-5 u192 5,000 n-Propylamine 00107-10-8 u194 5,000 Reserpine 00050-55-5 u200 5,000 Resorcinol 00108-46-3 u201 5,000 Streptozotocin 18883-66-4 u206 1 1,2,4,5-Tetrachlorobenzene 00095-94-3 u207 5,000xԌ1,1,1,2-Tetrachloroethane 00630-20-6 u208 100 Thiram 00137-26-8 u244 10 p-Toluidine 00106-49-0 u353 100  g/ 2,4,5-TP (Silvex)5  00093-72-1 f027 100 1,3,5-Trinitrobenzene 00099-35-4 u234 10 Trypan blue 00072-57-1 u236 10 Uracil mustard 00066-75-1 u237 10  g/ Warfarin and salts6  NA u248 100  '3'3Standard810q3'3'Standard810qM۰ x #]\  PC=P#  yO  1 EPA intends that the CAS Registry Number be used as the primary identifier of the chemicals proposed for addition.  yO   2 40 CFR section 261.33(f). These commercial chemical products, manufacturing chemical intermediates, or off - specification commercial chemical products are identified under RCRA regulations as toxic unless otherwise designated.  yOx  3 CWA section 307(a), Priority Pollutant List.  yO@  4 CERCLA section 112.  yO  5 This chemical is listed in 40 CFR 261.31, hazardous wastes from non - specific sources.  yO  6 Warfarin and salts are listed under 40 CFR section 261.33(f) only when present inconcentrations of 0.3% or less. Warfarin and salts are listed under 40 CFR section 261.33(e) only when present in concentrations greater than 0.3%.  yO( ) IV. EPA's Technical Review 6  yO 6  In order to be added to the EPCRA section 313 list of toxic substances, the Administrator must determine whether, in his judgement, there is sufficient evidence to establish any one of the following: (A) The chemical is known to cause or can reasonably be anticipated to cause significant adverse acute human health effects at concentration levels that are likely to exist beyond facility site boundaries as a result of continuous, or frequently recurring releases. (B) The chemical is known to cause or can reasonably be anticipated to cause in humans-- (i) cancer or teratogenic effects, or (ii) serious or irreversible-- (I) reproductive dysfunction, (II) neurological disorders, (III) heritable genetic mutations, or (IV) other chronic health effects. (C) The chemical is known to cause or can reasonably be anticipated to cause, because of-- (i) its toxicity, (ii) its toxicity and persistence in the environment, or (iii) its toxicity and tendency to bioaccumulate in the environment, a significant adverse effect on the environment of sufficient seriousness, in the judgement of the Administrator, to warrant reporting under this section. In Unit IV.B of this preamble, EPA identifies each of the chemicals proposed for addition to EPCRA section 313 and the specific statutory criteria upon which the proposed addition is based. For those chemicals that are being proposed for listing pursuant to EPCRA section 313(d)(2)(A), EPA assumes for purposes of this proposal that there are sufficient releases for the Agency to reasonably anticipate that the chemical will cause ``significant acute human health effects'' beyond the facility site boundaries. Due to the time limitations imposed by the statute and limitations in currently available production volume information, EPA was unable for this proposal to conduct exposure assessments for each of the chemicals proposed for listing pursuant to section 313(d)(2)(A). EPA requests comment on any release and exposure information for each of these chemicals or, in the alternative, evidence that there are no releases. With respect to those chemicals proposed to be added pursuant to section 313(d)(2)(C), EPA requests specific information on whether each of the chemicals satisfy that criterion.  {M# A. Introduction#0*$$Ԍ {O ԙ In evaluating each of the chemicals or chemical categories to determine if it meets the statutory criteria in section 313(d)(2), EPA's technical review of the petition to add 80 chemicals and 2 chemical categories includes a limited hazard analyses of the known health and environmental effects for these substances using criteria outlined in the  {OZ Draft Hazard Assessment Guidelines for Listing Chemicals on the Toxic Release Inventory (Draft Hazard Assessment  {O$ Guidelines, Ref. 32). These Draft Hazard Assessment Guidelines embody internal EPA practices that have been used  {O in the review of petitions to add and/or delete chemicals from EPCRA section 313. These Draft Hazard Assessment  {O Guidelines are available for review in the docket associated with this rulemaking. This draft document was available for distribution to the public at a public meeting on May 29, 1992. EPA is currently reviewing comments received as a result of that public meeting. A final version of these guidelines has not been promulgated. Requests for further information should be addressed to the person identified under the FOR FURTHER INFORMATION CONTACT Unit at the front of this document. EPA is proposing to add to EPCRA section 313 those chemicals that meet the criteria for ``sufficient for listing''  {Oj or ``may be sufficient for listing'' as defined in these draft guidelines. These terms are defined in the Draft Hazard  {O4 Assessment Guidelines as follows: (1) Sufficient for listing is a ``...category corresponding to the situation where there is a high level of confidence that a chemical produces a specific toxic effect, (e.g., cancer, developmental effects), or where a chemical has relatively high toxicity based on specified numerical screening criteria and there is a high confidence in the toxicity value,'' (2) may be sufficient for listing is a ``...category corresponding to the situation where there is suggestive but not definitve evidence that a chemical produces a specific toxic effect (e.g., cancer, developmental effects), or where a chemical has intermediate toxicity based on specified numerical screening criteria.'' (Ref. 32). Information on the health and environmental effects of the 80 chemicals and 2 chemical categories was obtained  {Ov from the following sources: EPA documents including Chemical Hazard Information Profiles (Ref. 12), Health  {O@ Advisories (Refs. 28 and 29), Health and Environmental Effects Profiles (Ref. 13), Reportable Quantity documents  {O  (Refs. 17 to 27), Pesticide Position Documents (Refs. 10 and 11), and Toxic Substances Control Act  {O (TSCA)/Inter-agency Testing Committee-Information Reviews (Ref. 39), Agency for Toxic Substances and Disease  {O Registry's Toxicological Profiles (Refs. 4 to 6), Shepard's Catalogue of Teratogenic Agents (Ref. 47), National  {Oh Research Council's Publication on Drinking Water and Health (Ref. 43), and National Toxicology Program's  {O2 Chemical Status Report (Ref. 44). On-  {O line searches of a limited number of data bases including Integrated Risk Information System (Ref. 38), Hazardous  {O Substances Data Bank (Ref. 37), Registry of Toxic Effects of Chemical Substances (Ref. 46), National Pesticide  {O Information Retrieval System (Ref. 42), Quantitative Structure-Activity Relationship (Ref. 45), and Aquatic  {OZ Information Retrieval (Ref. 3) were performed to supplement the information from the secondary sources listed above. Data on the chemicals and chemical categories were reviewed for evidence indicating adverse acute and chronic toxicity, carcinogenicity, mutagenicity, developmental and reproductive effects, neurotoxicity, and environmental fate and effects. This information is summarized in the support document for today's proposal (Ref. 35). A limited discussion of the health and environmental effects associated with each of the 80 chemicals and 2 chemical categories follows. All chemicals are listed as RCRA hazardous wastes at 40 CFR 261.33(f) for toxicity only unless otherwise noted.  {M B. Chemicals Proposed for Addition to EPCRA Section 313  {O,  1. Acetophenone (CAS No. 00098 - 86 - 2). Changes in the ratio of chronaxies of antagonist muscles, decreases in the albumin/globulin ratio of the blood, congestion of the cardiac vessels, and pronounced dystrophy of the liver  yO! was observed in male rats continuously exposed to acetophenone vapor at 0.07 milligrams per cubic meter (mg/m3) for 70 days. A lowest-observed-adverse-effect level (LOAEL) and a no-observed-adverse- effect level (NOAEL) of 0.0446 milligram per kilogram per day (mg/kg/day) and 0.00446 mg/kg/day wereN# 0*$$ determined, respectively. A supporting study reported degeneration of olfactory bulb cells in rats continuously  yO exposed to acetophenone vapor at 9 mg/m3 (5.7 mg/kg/day) for up to 3 months (Ref. 40). Therefore, there is sufficient evidence for listing acetophenone on EPCRA section 313 pursuant to section 313(d)(2(B) based on the available toxicity data for this chemical.  {O   2. Amitrole (CAS No. 00061 - 82 - 5). Amitrole is classified as a B2 carcinogen by EPA; i.e., a probable human carcinogen. It is classified as a Group 2B carcinogen by the International Agency for Research on Cancer (IARC); i.e., the compound is a possible human carcinogen based on sufficient evidence of carcinogenicity in animals and inadequate evidence in humans. Animal studies indicate that amitrole administered in the diet to rats or mice induced thyroid carcinomas (rats) and thyroid adenomas (mice) (Ref. 37). Therefore, there is sufficient evidence for listing amitrole on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  3. Azaserine (CAS No. 00115 - 02 - 6). Azaserine is classified as a Group B2 carcinogen by EPA; the compound is a probable human carcinogen based on sufficient data in animals and lack of data in humans. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. Animal studies indicate that azaserine administered in drinking water or by gavage to Wistar rats induced pancreatic tumors and that intraperitoneal injection induced both pancreatic and kidney adenocarcinomas. Additional animal studies support the conclusion that azaserine induces pancreatic tumors in Fischer and Lewis rats (Ref. 16). Therefore, there is sufficient evidence for listing azaserine on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  4. Benz(c)acridine (CAS No. 00225 - 51 - 4). Based on the lack of human data and limited evidence of carcinogenicity in animals, IARC classified benz(c)acridine as a Group 3 carcinogen; i.e., the agent is not classifiable as to its carcinogenicity. The compound has been placed on EPA's Carcinogen Assessment Group's list of carcinogens. However, it has no EPA carcinogenicity classification. Benz(c)acridine was a weak lung and liver carcinogen following intraperitoneal administration to newborn mice. Papillomas of the bladder were noted in a few rats which received the chemical via implantation into the bladder. Squamous-cell carcinomas were observed in a limited number of animals after the chemical was dermally applied to the neck of mice. It should be noted, however, that benz(c)acridine is a heterocyclic analogue of benz(a)anthracene, which is classified as a Group B2 carcinogen by EPA. Like benz(a)anthracene, benz(c)acridine has a bay-region benzo ring which could be metabolized to a bay-region diol-epoxide, a reactive intermediate that can interact with DNA to initiate carcinogenesis. Benz(c)acridine has been shown to be mutagenic in bacteria and mammalian cells. Furthermore, several methyl-substituted benz(c)acridines are moderately or highly carcinogenic (Refs. 34, 37, and 46). Therefore, there may be sufficient evidence for listing benz(c)acridine on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available mutagenicity data for this chemical and analogy to benz(a)anthracene.  {O  5. Benz(a)anthracene (CAS No. 00056 - 55 - 3). Benz(a)anthracene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient data from animal bioassays and the lack of data in humans. It is classified as a Group 2A carcinogen by IARC; i.e, a probable human carcinogen. Benz(a)anthracene produced tumors in mice exposed by gavage (pulmonary adenoma, hepatoma, and forestomach papillomas), intraperitoneal injection (pulmonary adenoma and liver carcinomas), subcutaneous injection (sarcoma), or intramuscular injection (fibrosarcomas and hemangioendotheliomas), and topical application. Benz(a)anthracene produced mutations in bacteria and in mammalian cells, and transformed mammalian cells in culture (Refs. 37 and 38). Therefore, there is sufficient evidence for listing benz(a)anthracene on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  yO  Acute aquatic toxicity test data indicate that based on a measured daphnid 96 - hour LC50 of 10 parts per billion  yO! (ppb), and estimated toxicity values of 61 ppb for fish 96 - hour LC50, 85 ppb for daphnid 48 - hour LC50, and 65  yOh" ppb for an algae 96 - hour EC50, benz(a)anthracene is highly toxic to aquatic organisms. Estimated toxicity values were derived using Quantitative Structure-Activity Relationship (QSAR) analysis based on the equation for neutral0# 0*$$ organic chemicals and an octanol-water partition coefficient (log P) of 5.66 (Refs. 3 and 45). There is sufficient evidence for listing benz(a)anthracene on EPCRA section 313 pursuant to section 313(d)(2)(C) based on available ecotoxicity information for this chemical, because the aquatic toxicity of benz(a)anthracene is less than 100 ppb and the estimated chemical half-life is greater than 100 days.  {O   6. Benzo(rst)pentaphene (CAS No. 00189 - 55 - 9). Benzo(rst)pentaphene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on the lack of human data and sufficient evidence of carcinogenicity in animals. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. Carcinomas of the skin were observed in mice following dermal exposure to the chemical. Pulmonary and hepatic tumors were noted in mice receiving intraperitoneal injections of the chemical (Ref. 37). Therefore, there is sufficient evidence for listing benzo(rst)pentaphene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  7. Benzo(a)phenanthrene (CAS No. 00218 - 01 - 9). Benzo(a)phenanthrene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient data from animal bioassays and the lack of human data. It is classified as a Group 3 carcinogen by IARC; i.e., not classifiable as to its carcinogenicity to humans. Benzo(a)phenanthrene produced carcinomas and malignant lymphomas in mice after intraperitoneal injection and skin carcinomas in mice following dermal exposure. Although there are no human data that specifically link exposure to benzo(a)phenanthrene to human cancers, it is a component in mixtures that have been associated with human cancer (Refs. 37 and 38). Therefore, there is sufficient evidence for listing benzo(a)phenanthrene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  8. Benzo(a)pyrene (CAS No. 00050 - 32 - 8). Benzo(a)pyrene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on inadequate human carcinogenicity data and sufficient data in animals. It is classified as a Group 2A carcinogen by IARC. IARC reported that there is sufficient evidence that benzo(a)pyrene is an animal carcinogen and limited evidence that it is a human carcinogen. Human data specifically linking benzo(a)pyrene to a carcinogenic effect are lacking. There are multiple animal studies in rodent and nonrodent species reported by IARC which demonstrate benzo(a)pyrene to be carcinogenic following administration by oral, intratracheal, inhalation, and dermal routes. Benzo(a)pyrene administered orally to rats and hamsters produced stomach tumors. Respiratory tract tumors have been observed in hamsters exposed to benzo(a)pyrene via the inhalation route of exposure (Refs. 14 and 38). Therefore, there is sufficient evidence for listing benzo(a)pyrene on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available carcinogenicity data for this chemical. Acute aquatic toxicity test data for benzo(a)pyrene indicate measured values of 5 ppb for a daphnid 96 - hour  yO LC50, whereas 72 - hour EC50 values for algae range from 5 ppb to greater than 4,000 ppb. Estimated toxicity values based on QSAR analysis using the equation for neutral organics and a log P of 6.12 give 96 - hour and 48 - hour  yO LC50 values for fish and daphnid of 25 and 36 ppb, respectively, and an algae 96 - hour EC50 of 28 ppb. Bioconcentration factors (BCF) for fish are 920 (measured) and 27,214 (QSAR estimation) (Refs. 3 and 45). There is sufficient evidence for listing benzo(a)pyrene on EPCRA section 313 pursuant to section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the acute aquatic toxicity of benzo(a)pyrene is less than 1 parts per million (ppm) and the BCF is approximately or greater than 1,000.  {O~  9. Bis(2-chloroethoxy)methane (CAS No. 00111 - 91 - 1). Inhalation of 120 ppm (0.85 milligram per liter (mg/L)) of bis(2- chloroethoxy)methane for 4 hours resulted in deaths of six of six rats. It has a high degree of toxicity in the rat orally and in the guinea pig by skin contact (Ref. 37). However, the dose levels were not reported. Therefore, there may be sufficient evidence for listing bis(2- chloroethoxy)methane on EPCRA section 313 pursuant to section 313(d)(2)(A) based on the available acute toxicity data for this chemical.0# 0*$$Ԍ {O  10. 4-Bromophenyl phenyl ether (CAS No. 00101 - 55 - 3). Aquatic toxicity test data for 4-bromophenyl phenyl  yO ether range from 0.36 ppm for the daphnid 48 - hour LC50 to 5.9 ppm for the fish 96 - hour LC50. Using QSAR analysis based on the equation for neutral organics and a log P of 5.24, acute toxicity values for aquatic organisms were consistently less than 1 ppm (0.17 ppm for fish and algae and 0.22 ppm for daphnids) (Ref. 3). These aquatic toxicity values, most of which are greater than 100 ppb and less than 1 ppm, indicate that there may be sufficient evidence for listing 4-bromophenyl phenyl ether on EPCRA section 313 pursuant to EPCRA section 313 (d)(2)(C) based on the available ecotoxicity information for this chemical.  {Oz  11. Carbonic difluoride (CAS No. 00353 - 50 - 4). Acute inhalation exposures to carbonic difluoride gas may induce hemorrhage and pulmonary edema in rats. A suitable NOAEL or LOAEL for this effect was not established.  yO  The rat LC50 for carbonic difluoride ranges from 243 to 1,215 mg/m3 (0.24 to 1.2 mg/L). Although several other acute inhalation studies suggest that the lung may be a target organ, none of the studies identified suitable NOAELs or LOAELs (Ref. 48). Therefore, the available evidence may be sufficient for listing carbonic difluoride on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(A) based on the available toxicity data for this chemical.  {O,  12. Chlorambucil (CAS No. 00305 - 03 - 3). Chlorambucil is classified as a Group A carcinogen by EPA; i.e., the compound is carcinogenic to humans based on sufficient evidence of carcinogenicity in humans and animals. It is classified as a Group 1 carcinogen by IARC; i.e., carcinogenic to humans. In a National Cancer Institute (NCI) bioassay, there was clear evidence of carcinogenicity of chlorambucil to rats and mice. Significant increases in malignant tumors of the mammary gland, central and peripheral nervous system, hematopoietic and lymphatic systems, and external auditory canal have been reported in female rats given chlorambucil by gavage. Chlorambucil also produced lymphosarcomas in male rats, lymphosarcomas and lung tumors in male and female mice, and ovarian tumors in female mice following intraperitoneal injection. Human data indicate that chlorambucil treatment is associated with an increased risk of developing acute leukemia (Refs. 18, 37, and 46). Therefore, there is sufficient evidence for listing chlorambucil on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  13. Chlornaphazine (CAS No. 00494 - 03 - 1). Using the Konemann equation for QSAR analysis, the 96 - hour  yO LC50 for fish is estimated to be less than 2.2 ppm based on a molecular weight of 268.2 and a log P of 4.5. Chlornaphazine is an alkylating agent and these chemicals are known to have excess toxicity (Ref. 45). Therefore, there is sufficient evidence for listing chlornaphazine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity data for this chemical because the estimated aquatic toxicity values are less than 2.2 ppm and the chemical will have excess toxicity.  {Ox  14. p-Chloro-m-cresol (CAS No. 00059 - 50 - 7). Although there is little data on the toxicity of p-chloro-m-cresol in humans, it has been rated as very toxic, with a probable lethal dose to humans of 50 to 500 mg/ kg. No chronic toxicity data were available for this chemical; however, acute data suggest that the compound may be hepatotoxic and/or neurotoxic. In male rats, a single oral or subcutaneous dose of 400 mg/kg p-chloro-m- cresol induced cellular changes in the liver and irregularities in the bile canaliculi. In mice, exposure to  yOb p-chloro-m-cresol via subcutaneous injection induced tremors, resulting in an LD50 of 360 mg/kg, whereas exposure  yO* via intravenous injection induced coma, resulting in an LD50 of 70 mg/kg (Refs. 37 and 46). Therefore, there may be sufficient evidence for listing p-chloro-m-cresol on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(A) based on the acute toxicity data available for this chemical.  {O  15. 4-Chloro-o-toluidine hydrochloride (CAS No. 03165 - 93 - 3). 4-Chloro-o-toluidine hydrochloride is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on inadequate evidence from human data and sufficient evidence from animal studies. It is classified as a Group 2B carcinogen by IARC; i.e., a probable human carcinogen. Epidemiology studies are inadequate in evaluating the carcinogenic potential of 4-chloro-o-toluidine hydrochloride in humans. In a long-term feeding study by NCI, 4-chloro-otoluidine hydrochloride induced hemangiomas, hemangiosarcomas, and vascular tumors in mice. An increase in the incidence of pituitary chromophobe adenomas, although not clearly treatment-related, was observed in female rats following dietary4# 0*$$ administration (Refs. 17 and 37). Therefore, there is sufficient evidence for listing 4-chloro-o-toluidine hydrochloride on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {OX  16. Crotonaldehyde (CAS No. 04170 - 30 - 3). Aquatic toxicity test data indicate measured fish 96 - hour LC50  yO" values of 0.65 to 3.5 ppm, a daphnid 48 - hour LC50 of 2.0 ppm, and an algal 96 - hour EC50 of 0.88 ppm (Refs. 3 and 31). There may be sufficient evidence for listing crotonaldehyde on EPCRA section 313 pursuant to section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the measured aquatic toxicity values for crotonaldehyde are less than 1 ppm but greater than 100 ppb.  {OB  17 Cyclophosphamide (CAS No. 00050 - 18 - 0). Cyclophosphamide is classified as a Group B1 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient data in animals and limited data in humans. It is classified as a Group 1 carcinogen by IARC; i.e., the compound is carcinogenic to humans. In an NCI bioassay, there was clear evidence of its carcinogenicity in mice and rats. Cyclophosphamide is carcinogenic in animals following oral or parenteral administration producing tumors in the bladder and other organs in rats, and leukemia, mammary tumors, and hematopoietic system tumors in mice. In humans it is associated with an increased incidence of bladder cancer and acute nonlymphocytic leukemia in patients treated with cyclophosphamide (Refs. 19 and 37). Therefore, there is sufficient evidence for listing cyclophosphamide on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {OL  18. Daunomycin (CAS No. 20830 - 81 - 3). Daunomycin is classified as a Group B2 carcinogen by EPA; i.e., the compound is probably carcinogenic to humans. It is classified as a Group 2B carcinogen by IARC; the compound is probably carcinogenic to humans based on the lack of human data and sufficient evidence of carcinogenicity data in animals. There was clear evidence of carcinogenicity in rats in NCI studies. In other studies, increased incidences of reticulosarcomas or leukemia were noted in mice receiving weekly oral doses of 12.5 mg/kg daunomycin for 22 weeks. Renal tumors, mammary tumors, and fibroadenomas have been observed following the intravenous injection of daunomycin in rats (Refs. 37 and 46). Therefore, there is sufficient evidence for listing daunomycin on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  19. DDD (CAS No. 00072 - 54 - 8). DDD, a metabolite of DDT, is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on an increased incidence of lung tumors in male and female mice, liver tumors in male mice, and thyroid tumors in male rats receiving DDD in the diet. In NCI studies, there was clear evidence of carcinogenicity in rats but not in mice (Refs. 4, 38, and 46). Therefore, there is sufficient evidence for listing DDD on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  yO@  Aquatic toxicity test data indicate that measured 96 - hour LC50 values for fish range from 2.5 ppb to 740 ppb;  yO the 96 - hour LC50 value for shrimp is 2.4 ppb, and for daphnids is 3.2 ppb. Estimated aquatic toxicity values, based  yO on QSAR analysis using the neutral organic equation and a log P of 6.96, are between 4 ppb for fish 96 - hour LC50  yO and 6 ppb for daphnid 48 - hour LC50, indicating that DDD is highly toxic to aquatic organisms (Refs. 3 and 45). There is sufficient evidence for listing DDD on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the aquatic toxicity values for DDD are less than 100 ppb and the estimated lop P value is greater than 5.5.  {O  20. DDT (CAS No. 00050 - 29 - 3). DDT is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on increased incidence of hepatic tumors in various mouse strains and in rats treated with DDT in the diet. It is classified as a Group 2B carcinogen by IARC; i.e., the compound is a probable human carcinogen (Refs. 38 and 43). In NCI studies, DDT was noncarcinogenic to mice and rats. DDT is a canceled pesticide (Ref. 30). Therefore, there is sufficient evidence for listing DDT on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  yOj"  Aquatic toxicity test data include measured fish 96 - hour LC50 values ranging from 0.4 ppb to 20 ppb. Estimated BCFs for DDT range from 44,594 to 114,524. The biodegradation half-life is estimated to be greater than 20 days2# 0*$$ and possibly greater than 100 days; the hydrolysis half-life may exceed 1,000 days (Refs. 3 and 41). There is sufficient evidence for listing DDT on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical because the measured aquatic acute toxicity of DDT is consistently less than 100 ppb.  {O   21. Dibenzo(a,h)anthracene (CAS No. 00053 - 70 - 3). Dibenzo(a,h)anthracene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient data from animal bioassays and no human data. Numerous studies that demonstrate complete carcinogenic activity and initiating activity of dibenzo(a,h)anthracene are summarized by IARC, which has classified it as a Group 2B carcinogen. Dibenzo(a,h)anthracene produced carcinomas (pulmonary and mammary) in rats when administered by the oral route. Mammary carcinomas were observed in two strains of mice following gavage (Ref. 38). Therefore, there is sufficient evidence for listing dibenzo(a,h)anthracene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {Ob  22. 1,4-Dichloro-2-butene (CAS No. 00764 - 41 - 0). 1,4- Dichloro-2-butene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a potential human carcinogen based on an increased incidence of nasal carcinomas in male and female rats in two inhalation studies. It is classified as a Group 3 carcinogen by IARC; i.e., not classifiable as to its carcinogenicity to humans.  {O 1,4-Dichloro-2-butene induced germ cell mutation and was mutagenic in in vivo and in vitro assays (Ref. 37). Therefore, there is sufficient evidence for listing 1,4-dichloro-2-butene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based upon the available carcinogenicity and mutagenicity data for this chemical.  {O  23. 1,2-Diethylhydrazine (CAS No. 01615 - 80 - 1). Several animal studies have demonstrated the tumorigenicity of this chemical in rats following subcutaneous or intravenous injection. The assessment of the carcinogenicity of 1,2-diethylhydrazine is currently under review by EPA. 1,2-Dimethylhydrazine, an analogous compound, is classified as a B2 Group carcinogen by EPA based on sufficient evidence from animal studies (the compound induced tumors at a number of sites in mice and rats) (Refs. 38 and 46). Therefore, there may be sufficient evidence for listing 1,2- diethylhydrazine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical and based on analogy with 1,2-dimethylhydrazine.  {OX  24. O,O-Diethyl S-methyl dithiophosphate (CAS No. 03288 - 58 - 2). Estimated aquatic toxicity values, derived  yO" using QSAR analysis with the equation for esters and a log P of 2.8, are 11.3 ppm for fish 96 - hour LC50, 29.8 ppm  yO for daphnid 48 - hour LC50, and 0.9 ppm for algae 96 - hour EC50 (Ref. 45). Because the algal estimated acute aquatic toxicity value is less than 1 ppm and O,O-diethyl S-methyl dithiophosphate is a pesticide component known to inhibit cholinesterase activity, there is sufficient evidence to list O,O-diethyl S-methyl dithiophosphate on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity data for this compound.  {O   25. Diethylstilbestrol (CAS No. 00056 - 53 - 1). Diethylstilbestrol is classified as a Group A carcinogen by EPA; the agent is carcinogenic to humans based on sufficient evidence in humans and animals. It is classified as a Group 1 carcinogen by IARC; i.e., carcinogenic to humans. Vaginal adenocarcinoma in young women was associated in seven out of eight cases with diethylstilbestrol treatment of the mother of the patients during the first trimester of pregnancy. Vaginal adenosis in female patients exposed in utero to diethylstilbestrol has also been reported. Animal studies indicate the induction of breast tumors in mice fed diethylstilbestrol in the diet, the induction of pituitary and hepatic tumors in rats fed diethylstilbestrol in the diet, and reproductive tract neoplasms in hamsters given diethylstilbestrol via gastric intubation. In addition, the compound is considered to be a known carcinogen by the National Toxicology Program (NTP) (Refs. 37, 46, and 47). Therefore, there is sufficient evidence for listing diethylstilbestrol on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O!  26. Dihydrosafrole (CAS No. 00094 - 58 - 6). Dihydrosafrole is classified as a Group 2B carcinogen by IARC; i.e., the compound is a probable human carcinogen based on the lack of data in humans and sufficient evidence of carcinogenicity in animals. Chronic oral administration of dihydrosafrole induced liver tumors in mice and esophageal6#0*$$ tumors in rats (Ref. 37). Therefore, there is sufficient evidence for listing dihydrosafrole on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data.  {O  27. 7,12-Dimethylbenz(a)anthracene (CAS No. 00057 - 97 - 6). 7,12-Dimethylbenz(a)anthracene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient evidence from animal studies and lack of data in humans. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. In animal studies, single or multiple doses of 7,12-dimethylbenz(a)anthracene induced mammary tumors in mice and rats exposed by gastric intubation or gavage, and topical application induced various tumors in rats, mice, and hamsters (Ref. 20). Therefore, there is sufficient evidence for including 7,12-dimethylbenz(a)anthracene on EPCRA section 313 pursuant to EPCRA section 313 (d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  28. 1,2-Dimethylhydrazine (CAS No. 00540 - 73 - 8). 1,2- Dimethylhydrazine is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on the lack of data in humans and sufficient evidence from animal studies. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. Chronic oral exposure to 1,2-dimethylhydrazine induced angiomas and angiosarcomas in Swiss mice, and oral administration induces angiosarcomas and lung adenomas in mice, angiosarcomas in hamsters, and intestinal tumors in rats. Single and multiple subcutaneous injections of 1,2-dimethylhydrazine induced tumors of the colon, large intestine, and kidney in rats and mice (Ref. 21). Therefore, there is sufficient evidence for including 1,2-dimethylhydrazine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  29. Ethylenebisdithiocarbamic acid, salts and esters (NA). Ethylenebisdithiocarbamates are pesticides regulated under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Products containing ethylenebisdithiocarbamates are restricted (Refs. 8, 30, and 33). A major toxicological concern from exposure to ethylenebisdithiocarbamic acid is the hazard to human health from the presence of ethylenethiourea, a contaminant, degradation product, and metabolite present in ethylenebisdithiocarbamic acid. Ethylenethiourea is carcinogenic, mutagenic, and teratogenic and causes thyroid toxicity (Refs. 37 and 42). No dose levels are available for these effects. Therefore, there may be sufficient evidence for listing ethylenebisdithiocarbamic acid, salts and esters on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available chronic toxicity data. Additional toxicity data on ethylenebisdithiocarbamic acid, salts and esters may be available on EPA/Office of Pesticide Program's (OPP) One-Liner data base; however, it is confidential business information (CBI) under FIFRA.  {O  30. Ethylidene dichloride (CAS No. 00075 - 34 - 3). Ethylidene dichloride is classified as a Group C carcinogen by EPA; i.e., the compound is a possible human carcinogen based on the lack of human data and limited evidence of carcinogenicity in two animal species (rats and mice) as shown by an increased incidence of mammary gland adenocarcinomas and hemangiosarcomas in female rats and an increased incidence of hepatocellular carcinomas and benign uterine polyps in mice in NCI bioassay. Because of similarities in structure and target organs, the carcinogenicity evidence for 1,2-dichloroethane is considered to support the classification of ethylidene dichloride as a possible human carcinogen (Refs. 5 and 38). Therefore, there may be sufficient evidence for including ethylidene dichloride on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  31. Ethyl methanesulfonate (CAS No. 00062 - 50 - 0). Ethyl methanesulfonate, an alkylating agent, is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on sufficient evidence from animal studies. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic in humans. In animal studies, ethyl methanesulfonate produced mammary carcinomas and renal tumors in rats following oral administration. Intraperitoneal injection of ethyl methanesulfonate induced lung carcinomas, renal tumors, and adenocarcinomas of the mammary gland in rats, and intraperitoneal or subcutaneous injection produced lung adenomas in mice (Refs. 22 and 37). Therefore, there is sufficient evidence for including ethyl methanesulfonate on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this2#0*$$ chemical.  {O  32. Fluoranthene (CAS No. 00206 - 44 - 0). Measured aquatic toxicity test data for fluoranthene ranges from 3.9  yO to greater than 560 ppm for fish 96 - hour LC50, 320 ppm for daphnid 48-hour LC50, and between 45 and 54.6 ppm  yOZ for the algae 96 - hour EC50. Only mysid shrimp show significant toxicity with a 96 - hour LC50 of 40 ppb. Estimated aquatic toxicity values, derived with QSAR analysis using the equation for neutral organics and a log P of 4.95, are  yO 0.25 ppm for the fish 96 - hour LC50, 0.33 ppm for the daphnid 48 - hour LC50, and 0.25 ppm for the algae 96 - hour  yO EC50. A BCF of 1,130 was also estimated (Refs. 37, 41, and 45). Therefore, there is sufficient evidence for listing fluoranthene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on available ecotoxicity data for this chemical, because some of the aquatic toxicity values are less than 100 ppb and because of the persistence and the bioaccumulation potentials.  {O  33. Formic acid (CAS No. 00064 - 18 - 6). The oral LD50 values for rats and mice are 1,210 mg/kg and 1,100 mg/kg, respectively. No chronic systemic, carcinogenicity, teratogenicity, or reproductive studies could be located in the available literature for formic acid. The principal hazard of formic acid is that of severe damage to the skin, eyes, or mucosal surfaces due to the chemical's corrosive properties. In humans, swallowing formic acid has caused a number of cases of severe poisoning and death with symptoms such as salivation, vomiting, burning sensation in the mouth, diarrhea, and pain (Ref. 38). Therefore, there may be sufficient evidence for listing formic acid on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(A) based on the available acute toxicity data for this chemical.  {O  34. Glycidaldehyde (CAS No. 00765 - 34 - 4). Glycidaldehyde is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on an increased incidence of unspecified tumors in rats and malignant tumors (fibrosarcomas, squamous cell carcinoma, adenocarcinomas, and undifferentiated sarcomas) in mice following subcutaneous injection and of skin carcinomas in mice following dermal application. The compound is classified as a Group 2B chemical by IARC; i.e., possibly carcinogenic to humans (Ref. 38). Therefore, there is sufficient evidence for listing glycidaldehyde on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  35. Hexachlorophene (CAS No. 00070 - 30 - 4). Dogs fed hexachlorophene at 0.75, 1.5, or 3.0 mg/kg/day in the diet for 13 weeks had status spongiosis in the brain, optic nerve, spinal cord, and sciatic nerve at all dose levels tested. A NOAEL was not established. In a 16 - week dietary study, cerebral edema and vacuolization in the white matter in the CNS were observed at 5 mg/kg/day (Ref. 46). Therefore, there is sufficient evidence for listing hexachlorophene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  yO@  Aquatic toxicity test data for hexachlorophene show that the measured 96 - hour LC50 for the fathead minnow is  yO 21 ppb whereas the estimated fish 96 - hour LC50, based on QSAR analysis using the equation for phenols and a log  yO P of 7.78, is 20 ppb. Measured terrestrial toxicity data for wildlife indicate that the oral LD50 for bobwhite quail is  yO 575 mg/kg (ppm) and the oral LD50 for female mallard ducks is 1,450 mg/kg (ppm) (Refs. 3, 37, and 45). There is sufficient evidence to list hexachlorophene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the estimated and measured aquatic acute toxicity values for hexachlorophene are less than 100 ppb.  {O  36. Hexachloropropene (CAS No. 01888 - 71 - 7). No carcinogenicity, neurotoxicity, teratogenicity, reproductive toxicity, or chronic systemic toxicity studies could be located in the available literature. The 30 - minute inhalation  yOJ LC50 value in rats is 425 ppm, and the intraperitoneal LD50 value in rats is 400 mg/kg (Ref. 46). Therefore, there may be sufficient evidence for listing hexachloropropene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(A) based on the available toxicity data for this chemical. The estimated aquatic toxicity values for hexachloropropene, based on QSAR analysis using the equation for  yOj" neutral organics and a log P of 4.36, are 1.1 ppm for the fish 96 - hour LC50, 1.4 for the daphnid 48 - hour LC50,  yO2# and 1.0 for the algae 96 - hour EC50 (Ref. 45). There may be sufficient evidence to list hexachloropropene on EPCRA2#0*$$ section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the aquatic acute toxicity values for hexachloropropene are consistently greater than 1 ppm but less than 10 ppm and the chemical half-life is estimated to be greater than 15 days.  {OX  37. Hydrogen sulfide (CAS No. 07783 - 06 - 4). The available information for the respiratory effects of hydrogen sulfide in humans is taken largely from reports of accidental exposures and/or occupational exposures; therefore, it is not possible to determine NOAELs or LOAELs from these data. Acute inhalation exposures to low levels of hydrogen sulfide have resulted in respiratory irritation effects in humans. Acute exposures to large amounts of hydrogen sulfide (approximately 250 ppm or more) have produced pulmonary edema, unconsciousness, respiratory paralysis, asphyxiation, and/or death in some individuals. Similar effects are also noted in animals. In a subchronic study, inflammation of the nasal mucosa occurred in mice following 90 - day inhalation of hydrogen sulfide, resulting  yO in a NOAEL of 42.5 mg/m3 (30.5 ppm; Human Equivalent Concentration (HEC) is 0.93 mg/m3) and a LOAEL of  yO 110 mg/m3 (80 ppm; HEC is 2.4 mg/m3). Other respiratory effects, such as alveolar edema, infiltrates in the bronchioles, cellular necrosis, hyperplasia, and exfoliation in various respiratory tissues, have been reported in rats (Ref. 38). Therefore, there is sufficient evidence for listing hydrogen sulfide on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based upon the available respiratory toxicity data for this chemical.  yO  Aquatic toxicity test data for hydrogen sulfide show that measured fish 96 - hour LC50 values range from 7 to 776 ppb (Ref. 3). There is sufficient evidence to list hydrogen sulfide on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the acute fish toxicity values for hydrogen sulfide include values less than 100 ppb.  {O  38. Indeno[1,2,3-cd]pyrene (CAS No. 00193 - 39 - 5). Indeno[1,2,3-cd]pyrene is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on increased incidence of epidermoid carcinomas in a lung implantation study in rats, skin tumors from dermal application in several strains of mice, and sarcomas following subcutaneous injection in mice. Also, positive results were obtained by indeno[1,2,3-cd]pyrene in bacterial gene mutation assays. The compound is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans (Refs. 37 and 38). Therefore, there is sufficient evidence for listing indeno[1,2,3-cd]pyrene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  39. Kepone (CAS No. 00143 - 50 - 0). Kepone is classified as a Group B2 carcinogen by EPA, i.e., the compound is a probable human carcinogen. It is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. The compound has been shown to induce hepatocellular carcinomas in mice and rats following dietary exposure (Refs. 24 and 37). Kepone is a canceled pesticide (Ref. 30). Therefore, there is sufficient evidence for listing kepone on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  yO  Aquatic toxicity test data for kepone show that the measured 48 - hour EC50 for daphnids is 260 ppb and that the  yO 96 - hour LC50 values for fish range from 30 to 72 ppb. The BCF for kepone in fish is greater than 1,000 (1,100 to 2,200 in fathead minnow) (Ref. 37). Because kepone is very stable in the environment (no degradation after 56 days) and the aquatic toxicity is less than 100 ppb, there is sufficient evidence for listing kepone on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity data for this chemical.  {O  40. Lasiocarpine (CAS No. 00303 - 34 - 4). Lasiocarpine is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen. Lasiocarpine is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. Lasiocarpine induced angiosarcoma of the liver and metastatic angiosarcomas in the lungs of rats via dietary ingestion. Lasiocarpine induced hepatocellular carcinomas, squamous-cell carcinomas of the skin, pulmonary adenomas, and tumors in the testes and intestines in rats via intraperitoneal injection. In an NTP bioassay, lasiocarpine was carcinogenic to male and female rats (Refs. 25 and 37). Therefore, there is sufficient evidence for listing lasiocarpine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.0#0*$$Ԍ {O  41. Malononitrile (CAS No. 00109 - 77 - 3). Humans injected with 1 to 6 mg/kg malononitrile for treatment of schizophrenia and depression exhibited tachycardia, nausea, flushing, vomiting, headache, shivering, muscle spasms, and numbness within minutes of exposure. Subcutaneous injection of 14 mg/kg malononitrile produced dyspnea and  yOZ convulsions in rats. Acute exposure to 200 to 300 mg/m3 (0.2 to 0.3 mg/L) malononitrile induced restlessness, changes in respiratory rate, incoordination, tremors, convulsions and death in mice and rats. Some of these effects may have been secondary to cyanosis which accompanied the effects in both humans and animals (Ref. 37). None of these data are sufficient to derive NOAEL or LOAEL values. However, taken together, there is sufficient evidence for listing malononitrile on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  yO   Aquatic toxicity test data for measured fish 96 - hour LC50 values range from 0.57 ppm to 1.8 ppm. Estimated  yO 48 - hour LC50 for daphnid derived from QSAR analysis is 0.64 ppm. The estimated hydrolysis half-life is 21 days and the estimated photolysis half-life is 2.7 years. Based on a water solubility of 133,000 mg/L, the BCF is estimated to be 0.8 (Refs. 37, 41, and 45). There may be sufficient evidence to list malononitrile on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity data for this chemical, because the aquatic toxicity values for malononitrile are less than 1 ppm but greater than 100 ppb.  {O  42. Melphalan (CAS No. 00148 - 82 - 3). Melphalan is classified as a Group 1 carcinogen by IARC; the agent is carcinogenic to humans. Leukemia and reticulosarcoma developed in cancer patients following treatment with melphalan (Refs. 37 and 46). Dermal exposure to melphalan induced papillomas and skin carcinoma in mice. Lung tumors and lymphosarcomas were induced in mice and peritoneal sarcomas were induced in rats following intraperitoneal injection of melphalan. In an NCI bioassay, melphalan was carcinogenic to mice and rats. Melphalan is considered as a known carcinogen by NTP. Therefore, there is sufficient evidence for listing melphalan on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O4  43. Methacrylonitrile (CAS No. 00126 - 98 - 7). In dogs, methacrylonitrile induced convulsions, loss of motor control in the hindlimbs, and histopathological brain lesions following a 90 - day inhalation exposure, resulting in  yO a NOAEL of 9 mg/m3 (3.2 ppm; the adjusted dose (ADJ) is 0.34 mg/kg/day) and a LOAEL of 24 mg/m3 (8.8 ppm; the ADJ is 0.85 mg/kg/day). No toxic effects occurred in rats when exposed to higher levels than those given to the dogs. In other studies, convulsions have been reported in rats and mice when acute exposures were in excess of 600 ppm methacrylonitrile (Ref. 38). Therefore, there is sufficient evidence for listing methacrylonitrile on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based upon the available neurotoxicity data for this chemical.  {O  44. Methyl chlorocarbonate (CAS No. 00079 - 22 - 1). No chronic systemic, carcinogenicity, teratogenicity, or reproductive studies could be located in the available literature for methyl chlorocarbonate. A 10 - minute exposure to 190 ppm (1 mg/L) by inhalation is reported to be lethal in humans; other conditions of the exposure were not  yO reported. The 1 - hour inhalation LC50 for rats is 88 ppm (0.5 mg/L) (Ref. 38). Therefore, there may be sufficient evidence for listing methyl chlorocarbonate on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(A) based on the available acute toxicity data for this chemical.  {O`  45. 3-Methylcholanthrene (CAS No. 00056 - 49 - 5). There are numerous studies that suggest that 3-methylcholanthrene is carcinogenic to mice, rats, rabbits, guinea pigs, hamsters, dogs, and cats exposed via the oral and dermal routes and by injection at various sites. For instance, oral exposures have induced lymphoma in the blood of rats and mice; lung tumors in mice; and skin tumors in rats and hamsters. Dermal exposures have induced skin tumors in rats, mice, and hamsters. Tumors at the site of injection have occurred in the skin, brain, lungs, reproductive organs, musculoskeletal system, and kidneys in rats, mice, rabbits, and guinea pigs. Finally, 3-methylcholanthrene was positive in a battery of mutagenicity assays (Ref. 46). Therefore, there is sufficient evidence for listing 3- methylcholanthrene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical. Measured aquatic toxicity test data indicate that the oyster 7 - day BCF is 3. The estimated aquatic toxicity, based2#0*$$  yO on QSAR analysis, is 38.5 ppb for the fish 96 - hour LC50 (Refs. 3 and 41). There is sufficient evidence for listing 3-methylcholanthrene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical, because the estimated aquatic acute toxicity of 3- methylcholanthrene is less than 100 ppb.  {O   46. Methyl mercaptan (CAS No. 00074 - 93 - 1). Methyl mercaptan (thiomethanol) induced coma in one individual following daily inhalation exposures for 1 week (no dose levels available). Three workers experienced adverse CNS effects following exposure to an unknown level of a mixture of chemicals containing methyl mercaptan. These effects include unconsciousness, dizziness, convulsions, apnea, and general weakness. Coma induction also was noted in rats following exposure to methyl mercaptan via acute inhalation, resulting in a NOAEL of 1,200 ppm (2.3 mg/L) and a LOAEL of 1,400 ppm (2.7 mg/L). Intraperitoneal injection of 4.8 mg/kg thiomethanol also induced coma in rats (Refs. 1 and 6). Therefore, there may be sufficient evidence for listing methyl mercaptan on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based upon the available neurotoxicity data for this chemical.  {Ob  47. N-Methyl-N'-nitro-N-nitrosoguanidine (CAS No. 00070 - 25 - 7). N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen. N- methyl-N'-nitro-N-nitrosoguanidine is classified as a Group 2A carcinogen by IARC; probably carcinogenic to humans. N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal tumors (adenomas, adenocarcinomas, carcinomas, fibrosarcomas, papillomas, sarcomas) in mice, rats, rabbits, hamsters, and dogs via oral exposure (in drinking water, intragastrically, or by gavage). In addition, skin papillomas, fibrosarcomas, and carcinomas were noted in mice and rats following dermal application of N-methyl-N'-nitro-N-  {O nitrosoguanidine. Finally, the compound was genotoxic in a battery of in vivo and in vitro assays (Refs. 23 and 37). Therefore, there is sufficient evidence for listing N-methyl-N'-nitro-N-nitrosoguanidine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O6  48. 2-Methylpyridine (CAS No. 00109 - 06 - 8). In humans, 2- methylpyridine is reported to induce weight loss, nausea, diarrhea, vomiting, weakness, ataxia, unconsciousness, facial flushing, skin rash, giddiness, headache, and increases in heartand respiration rates. However, no information was provided as to the incidence of these effects or the exposure conditions. Two of six rats surviving a single oral dose of 950 mg/ kg 2-methylpyridene showed signs of encephalomalacia (areas devoid of neuronal elements, neurons, and supportive cells, normally found in brain tissues). In another study in rats, exposure to 300 mg/kg/day of the chemical for 10 days decreased the number of cells of the hypothalamic- hypophyseal neurosecretory system. Doses (route unspecified) of 2- methylpyridene as low as 0.0025 mg/kg for 6 months induced functional and dystrophic changes in the cerebral cortex and morphological changes in neurons. The highest dose (0.05 mg/kg) resulted in constant demyelination of nerve pathways in the brain. In mice, oral sublethal doses induced short periods of excitation followed by depression of the CNS and sleepiness (Refs. 12 and 37). Therefore, there is sufficient evidence for listing 2- methylpyridine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  {O  49. Methylthiouracil (CAS No. 00056 - 04 - 2). Methylthiouracil is classified as a B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen. Methylthiouracil is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. Methylthiouracil induced thyroid adenomas in mice, rats, and hamsters and thyroid carcinomas in hamsters via oral dietary or drinking water exposure. In addition, pituitary and thyroid adenomas and tumors at the site of implantation were induced in rats via subcutaneous implantation of methylthiouracil. Also, kidney adenomas and adenocarcinomas were induced in rats via oral dietary or drinking water exposure to methylthiouracil (Refs. 26 and 37). Therefore, there is sufficient evidence for listing methylthiouracil on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.2#0*$$Ԍ {O  50. Mitomycin C (CAS No. 00050 - 07 - 7). Mitomycin C is classified as a Group B2 carcinogen by EPA; i.e., the compound is probably carcinogenic in humans. It is classified as a Group 2B carcinogen by IARC; i.e., the compound is a possible human carcinogen based on sufficient evidence of carcinogenicity in animals and the lack of human data. Mitomycin C produced tumors in mice treated by subcutaneous injection (local sarcomas) and in rats treated by intraperitoneal injection (peritoneal sarcomas), and intravenous injection (malignant tumors). In an NCI bioassay, there was clear evidence of the carcinogenicity of mitomycin C to rats (Ref. 37). Therefore, there is sufficient evidence for listing mitomycin C on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {OB  51. N-Nitrosodiethanolamine (CAS No. 01116 - 54 - 7). N- Nitrosodiethanolamine is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on an increased incidence of liver tumors and tumors of the nasal cavity in two strains of rats via oral exposure in drinking water. Carcinomas of the nasal cavity and papillomas of the trachea were induced in hamsters following either subcutaneous injection, oral swabbing, or skin painting exposures to N- nitrosodiethanolamine. The compound is classified as a Group 2B carcinogen by IARC; i.e., possibly carcinogenic to humans. In an NCI bioassay, there was clear evidence of its carcinogenicity in rats (Refs. 37, 38, and 46). Therefore, there is sufficient evidence for listing N-nitrosodiethanolamine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {OL  52. N-Nitroso-N-methylurethane (CAS No. 00615 - 53 - 2). N- Nitroso-N-methylurethane is classified by EPA as a Group B2 carcinogen; i.e., the compound is a probable human carcinogen. N-Nitroso-N- methylurethane is classified as Group 2B carcinogen by IARC; i.e., the compound is possibly carcinogenic to humans. Exposures in utero, by either intravenous or intraperitoneal injection, induced tumors of the nervous system, kidney, lungs, mammary and adrenal glands, and thyroid in the offspring of rats. Drinking water and gavage exposures induced tumors of the forestomach and the esophagus in rats; intragastric exposures induced tumors of the forestomach and esophagus in hamsters; and drinking water exposures induced stomach tumors in guinea pigs. Tumors of the respiratory system, primarily the lung, were observed in guinea pigs via drinking water; in mice, guinea pigs, and hamsters via subcutaneous injection; in mice via intraperitoneal injection; and in rats and rabbits via intravenous injection (Refs. 27, 37, and 46). Therefore, there is sufficient evidence for listing N-nitroso-N-methylurethane on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {Ov  53. N-Nitrosopyrrolidine (CAS No. 00930 - 55 - 2). N- Nitrosopyrrolidine is classified as a Group B2 carcinogen by EPA; i.e., the compound is a probable human carcinogen based on the induction of liver carcinomas and/or adenomas in two strains of rats and papillary mesotheliomas of the testes in one strain of rat via oral exposure. Also, there was a low incidence of lung adenomas in mice via drinking water exposure. The compound is classified as a Group B2 carcinogen by IARC; i.e., it is possibly carcinogenic to humans (Ref. 38). Therefore, there is sufficient evidence for listing N-nitrosopyrrolidine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  54. 5-Nitro-o-toluidine (CAS No. 00099 - 55 - 8). 5-Nitro-o- toluidine is classified as a Group C carcinogen by EPA; i.e., the compound is possibly carcinogenic to humans. It is classified as a Group 3 chemical by IARC, based on limited evidence of carcinogenicity in animals. In an NCI bioassay, hepatocarcinomas, hemangiomas, and hemangiosarcomas were observed in mice following dietary exposure. No carcinogenic effects were noted in rats when exposed to lower doses than those used in mice. In addition, two structural analogues of 5-nitro-o-toluidine, o-toluidine, and 2-methoxy-5- nitro-aniline, were carcinogenic in both rats and mice. 5-Nitro-o-toluidine is expected to be bioactivated and to exert its carcinogenicity via the same mechanism as these two aromatic compounds. 5-Nitro-o-toluidine also has been2#0*$$ shown to be mutagenic in the Ames test (Refs. 34 and 37). Therefore, there may be sufficient evidence for listing 5-nitro-o-toluidine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical and on analogy to similar aromatic compounds.  {OX  55. Paraldehyde (CAS No. 00123 - 63 - 7). In humans, paraldehyde induces coma, severe hypotension, cardiac failure, sciatic nerve injury, and CNS depression. Chronic exposure may produce hallucinations; delusions; memory, intellect, and speech impairment; unsteady gait, tremors, anorexia, and weight loss. Nerve injury resulted from intramuscular exposure; other routes of exposure were not reported. Exposure levels were not reported for these effects. Convulsions occurred in a man following intramuscular exposure to 568 mg/kg paraldehyde (Refs. 37 and 46). Because the dose levels were not indicated in case studies, the lowest level for the CNS effects in humans could not be determined. Therefore, the available evidence may be sufficient for listing paraldehyde on EPCRA section 313 pursuant to section 313(d)(2)(B) based on the available neurotoxicity data.  {O  56. Pentachlorobenzene (CAS No. 00608 - 93 - 5). The measured aquatic toxicity test data for pentachlorobenzene  yOd ranged from 0.25 to 0.83 ppm for fish 96 - hour LC50 to 5.3 ppm for the daphnid 48 - hour LC50. A 21 - day daphnid  yO, chronic LC50 of 0.24 ppm was also determined. BCFs for fish ranged from 3.3 to 55 for 31 - day tests. Estimated aquatic toxicity values, based on QSAR analysis using the equation for neutral organics and a log P of 5.71, are 0.06  yO ppm for the fish 96 - hour LC50, 0.08 ppm for the daphnid 48 - hour LC50, and 0.07 ppm for the algae 96 - hour  yO EC50. The estimated chemical half- life of pentachlorobenzene is 0.5 to 1 year; the estimated volatilization half-life from water is 60 days; and the atmospheric photolysis half-life is estimated to be 271 days (Refs. 3 and 45). Based on measured and estimated acute aquatic toxicity values that are consistently less than 1 ppm and the persistence of pentachlorobenzene, there is sufficient evidence for listing pentachlorobenzene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity data for this chemical. In rats, pentachlorobenzene induced anomalous rib number in the offspring of female rats that were exposed by stomach tube to 50 to 200 mg/ kg/day during days 6 to 15 of gestation. At the high dose, sternal defects and decreased mean fetal weight were also noted in these offspring. Pentachlorobenzene also induced tremors in the offspring of rats following maternal dietary exposure to greater than 250 to 1,000 ppm. The high dose was lethal for most of these offspring. It is not known if the tremors were the result of gestational exposure or exposure through lactation. No maternal effects were noted. Pentachlorobenzene induced unspecified developmental effects and decreased fetal body weight in the offspring of rats following maternal dietary exposure during gestation (Ref. 37). Duration and exposure levels were not reported and these effects did not occur in mice. Therefore, there may be sufficient evidence for listing pentachlorobenzene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available developmental toxicity data for this chemical.  {O  57. Pentachloroethane (CAS No. 00076 - 01 - 7). Pentachloroethane is reported to induce headaches, dizziness, confusion, drowsiness, convulsion, coma, and respiratory arrest in humans. No exposure information was provided. Exposure to pentachloroethane induced narcosis preceded by restlessness and excitement in dogs following repeated inhalation of 10 ml and CNS depression in cats following inhalation of 146 ppm (1.5 mg/L) 8 to 9 hours daily for 23 days. Pentachloroethane induced the behavioral effects of altered sleep in rats and dogs; the rats also exhibited  yO ataxia. The LD50 values associated with these effects are 920 mg/kg in rats following subcutaneous injection, and 500 mg/kg in dogs following oral exposure (Refs. 7, 37, and 46). Therefore, there may be sufficient evidence for listing pentachloroethane on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  {O  58. Phenacetin (CAS No. 00062 - 44 - 2). Phenacetin is classified as a Group 2A carcinogen by IARC; i.e., the compound is probably carcinogenic to humans. It has been associated with renal tumors in humans and animals. In humans, carcinoma of the renal pelvis, ureter, and bladder were noted in chronic users of phenacetin (Ref. 37). Therefore, there is sufficient evidence for listing phenacetin on EPCRA section 313 based on the available0#0*$$ carcinogenicity data for this chemical.  {O  59. Pronamide (CAS No. 23950 - 58 - 5). There are several studies that suggest that pronamide induces liver tumors in mice following oral exposure to doses as low as 500 ppm (Refs. 9, 10, 29, and 37). Therefore, there may be sufficient evidence for listing pronamide on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical. The use of pronamide as a pesticide is restricted under FIFRA (Refs. 9, 10, and 30). Additional toxicity data may be available on EPA's One-Liner data base; however, it is CBI under FIFRA.  {Oz  60. Reserpine (CAS No. 00050 - 55 - 5). Reserpine induced coma, hypothermia, and bradycardia in three children who ingested large doses of the drug (specific quantity not specified). In dogs, CNS depression, muscle tremors, and parkinsonian-like syndrome resulted from daily exposure (route unspecified) to 18 to 39 micrograms/kilogram (ug/kg) for up to 1 year. In another study in dogs, chronic oral administration of low dose levels of reserpine (0.137 mg/kg) caused CNS depression and muscle tremors (Ref. 37). Therefore, there is sufficient evidence for listing reserpine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  {O  61. Streptozotocin (CAS No. 18883 - 66 - 4). Streptozotocin is classified as a Group 2B carcinogen by IARC; i.e., the compound is possibly carcinogenic to humans. No carcinogenicity data are available in humans; however, there is sufficient evidence of carcinogenicity in animals. In male and female mice, intraperitoneal injection of streptozotocin induced tumors of the lungs, kidneys (males only), and uterus (females only). Kidney tumors and pancreatic cell tumors also resulted from intravenous injection of streptozotocin in rats. In addition, hamsters developed tumors of the bile duct and liver following intraperitoneal injection of streptozotocin (Refs. 37 and 44). Therefore, there is sufficient evidence for listing streptozotocin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity toxicity data for this chemical.  {O6  62. 1,2,4,5-Tetrachlorobenzene (CAS No. 00095 - 94 - 3). In rats, 1,2,4,5-tetrachlorobenzene induced kidney lesions in males following dietary exposure for 13 weeks, resulting in a LOAEL of 50 ppm (3.4 mg/kg/ day). In addition, liver lesions were observed in female rats exposed to 500 ppm under the same conditions. In another study in rats, 1,2,4,5- tetrachlorobenzene caused liver and kidney pathology following 28 - day exposure to doses as low as 3.4 mg/kg/day. The NOAEL for this study was 0.4 mg/kg/day. In the same study, 1,2,4,5-tetrachlorobenzene (32 mg/kg/day) significantly increased liver weights (20 to 30 percent) and induced hepatic microsomal enzymes 2 to 12-fold (Ref. 38). Although systemic toxicity in other animal species could not be located in the available literature on 1,2,4,5-tetrachlorobenzene, there is sufficient evidence for listing 1,2,4,5-tetrachlorobenzene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based upon the available hepatotoxicity and renal toxicity data for this chemical.  yO  The measured aquatic toxicity test data for 1,2,4,5-tetrachlorobenzene shows that acute fish 96 - hour LC50 values  yO range from 1.2 to 10 ppm whereas the daphnid 48 - hour LC50 value is greater than 530 ppm. Estimated aquatic toxicity values, based on QSAR analysis using the equation for neutral organics and a log P of 4.99, are 0.25 ppm  yO( for the fish 96 - hour LC50, 0.33 ppm for the daphnid 48 - hour LC50, and 0.24 ppm for the algae 96 - hour EC50. A fish BCF of 3,484 was also estimated based on the log P (Refs. 3 and 45). Estimated aquatic toxicity values for fish, daphnid, and algae are all greater than 100 ppb but less than 1 ppm. Based on the estimated aquatic acute toxicity of 1,2,4,5-tetrachlorobenzene, there may be sufficient evidence for listing 1,2,4,5-tetrachlorobenzene on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical.  {O  63. 1,1,1,2-Tetrachloroethane (CAS No. 00630 - 20 - 6). 1,1,1,2- Tetrachloroethane is classified as a Group C carcinogen by EPA; i.e., the compound is a possible human carcinogen based on an increased incidence of combined hepatocellular adenomas and carcinomas in female mice following oral exposure. The maximum tolerated dose (MTD) was exceeded at the high dose. There is inadequate evidence from2#0*$$ human studies. The compound is classified as a Group 3 chemical by IARC; i.e., it is not classifiable as to its carcinogenicity to humans. The study conducted by NTP was inadequate for evaluating carcinogenicity (Refs. 38 and 46). Therefore, there may be sufficient evidence for listing 1,1,1,2-tetrachloroethane on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical. Oral exposure to 250 mg/kg/day of 1,1,1,2-tetrachloroethane caused inactivity and incoordination in rats. No NOAEL was established. CNS involvement (sluggishness, incoordination, and weakness) also was seen in mice exposed to 500 mg/kg/day of 1,1,1,2-tetrachloroethane via the oral route; the NOAEL was 250 mg/kg/day (Ref. 38). Therefore, there may be sufficient evidence for listing 1,1,1,2-tetrachloroethane on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  {O  64. Thiram (Thioperoxydicarbonic diamide) (CAS No. 00137 - 26 - 8). The measured aquatic toxicity test data  yO for the fish 96 - hour LC50 range from 0.67 to 270 ppb, with a daphnid 48 - hour LC50 of 210 ppb, and an algae 96  yO - hour EC50 of 1,000 ppb. A daphnid 21 - day chronic LC50 of 8 ppb was also measured. Estimated aquatic toxicity  yOb values, based on QSAR analysis, are 7.0 to 10.1 ppm for the fish 96 - hour LC50 and 8.2 ppm for daphnid 96 - hour  yO* LC50 (Refs. 3 and 41). Based on measured acute aquatic toxicity values of less than 100 ppb and an estimated chemical half-life of greater than 14 days, there is sufficient evidence to list thiram on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical. In rats, thiram (thioperoxydicarbonic diamide) induced weakness, ataxia, varying degrees of hindlimb paralysis, and calcified masses in the basal ganglia and in the cerebellum following dietary exposure for 2 years, resulting in a LOAEL of 300 ppm (The ADJ is 15 mg/kg/day) and a NOAEL of 100 ppm (The ADJ is 5 mg/kg/day). In another study in rats, dietary exposure to thioperoxydicarbonic diamide for 80 weeks resulted in alopecia, ataxia, and hind limb paralysis. The LOAEL and NOAEL were 25.5 mg/kg/day and 6.1 mg/kg/ day, respectively. In another study, thiram caused convulsions, thyroid hyperplasia, and calcification of the cerebellum, hypothalamus, and medulla oblongata in rats following dietary exposure for 2 years (Refs. 37 and 38). No NOAEL or LOAEL values were available for these data. Although neurotoxicity data in other animal species could not be located in the available literature, there may be sufficient evidence for listing thiram on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurotoxicity data for this chemical.  {OR  65. p-Toluidine (CAS No. 00106 - 49 - 0). Although o-toluidine has been shown to be carcinogenic in rats and mice, there is only limited evidence on the carcinogenicity of p-toluidine (induction of liver tumors in male and female mice). p-Toluidine is expected to be a weaker carcinogen than o-toluidine because it is believed that the ortho methyl group contributes to the carcinogenic effects of o-toluidine. Previous structure activity relationship analysis has suggested that the ortho methyl group in o-toluidine and in other aromatic amines appears to have an enhancing effect on the activation of the amino group in these compounds. In addition, p- toluidine was not mutagenic in a number of genotoxicity studies (Refs. 13 and 42). Therefore, there may be sufficient evidence for listing p-toluidine on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the limited carcinogenicity data available for this chemical and based on analogy with o-toluidine.  {O\  66. 2,4,5-TP (Silvex) (CAS No. 00093 - 72 - 1). The use of 2,4,5-TP is canceled pursuant to FIFRA primarily due to 2,4,5-TP's contamination with dioxins. 2,4,5-TP as a separate chemical has not been widely studied. Cleft palate was observed in mice fed 379 mg/kg 2,4,5-TP daily during gestation. At 50 mg/kg/day, reduced pup weight and incomplete skull ossification were noticed in rats. The NOAEL for developmental toxicity was 25 mg/kg/day (Ref. 38). Therefore, there may be sufficient evidence for listing 2,4,5-TP on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available developmental toxicity data for this chemical. Unspecified histopathological changes in the liver were observed in dogs fed diets containing 2,4,5-TP for 2 years. A LOAEL of 100 ppm (2.5 mg/kg/ day) and a NOAEL of 30 ppm (0.75 mg/kg/day) were determined. However, no adverse effects were seen in rats fed diets containing 0, 10, 30, 100 ppm 2,4,5-TP for 2 years. There may be sufficient evidence for listing 2,4,5-TP on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available toxicity data for this.#0*$$ chemical.  yO  Aquatic toxicity test data indicate that measured 96 - hour LC50 values for fish range from 0.35 ppm for mosquito  yO fish to 86 ppm for bluegills; the daphnid 48 - hour LC50 is 140 ppm; and the oyster 48 - hour EC50 is 5.9 ppm. These data indicate that 2,4,5-TP is highly toxic to some aquatic organisms at values less than 1 ppm but only moderately toxic to other organisms, such as daphnids where the values exceed 100 ppb (Ref. 3). Therefore, because the aquatic toxicity values for 2,4,5-TP are less than 1 ppm but greater than 100 ppb, there may be sufficient evidence to list 2,4,5-TP on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available ecotoxicity information for this chemical.  {O@  67. 1,3,5-Trinitrobenzene (CAS No. 00099 - 35 - 4). In rats, oral exposure to 1,3,5-trinitrobenzene induced depression, hyperpnea, gasping, salivation, cyanosis, loss of normal reflexes, tachycardia, coma, and death, resulting  yO in an approximate LD50 of 505 mg/kg. A lower oral LD50 value (280 mg/kg) was reported for rats in a more recent study (Refs. 36, 38, and 46). Therefore, there may be sufficient evidence for listing 1,3,5-trinitrobenzene on EPCRA section 313 pursuant to EPCRA section313(d)(2)(B) based on the neurotoxicity data available for this chemical.  {O*  68. Trypan blue (CAS No. 00072 - 57 - 1). Trypan blue is classified as a Group B2 carcinogen by EPA; i.e., it is probably carcinogenic to humans, based on sufficient evidence in animals and no evidence in humans. The compound is classified as a Group 2B carcinogen by IARC; i.e., the compound is possibly carcinogenic to humans. Following subcutaneous injection in rats, trypan blue induced tumors of the reticuloendothelial system, hepatic lymph nodes, mesenteric lymph nodes, thymus, thymic lymph nodes, nonabdominal lymph nodes, and kidney (Refs. 37 and 46). Therefore, there is sufficient evidence for listing trypan blue on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {O  69. Uracil mustard (CAS No. 00066 - 75 - 1). Uracil mustard is classified as a Group B2 chemical by EPA; i.e., it is a possible human carcinogen. The compound is classified as a Group 2B carcinogen by IARC; i.e., it is possibly carcinogenic to humans. In an NCI bioassay, uracil mustard was carcinogenic to mice and rats. No carcinogenicity data are available in humans; however, there is sufficient evidence of carcinogenicity in animals. Following intraperitoneal injection, uracil mustard induced lung adenomas and adenocarcinomas in mice. In another study in mice, uracil mustard induced lung tumors, liver tumors, ovarian tumors, and lymphomas following intraperitoneal injection. Following intraperitoneal injection in rats, uracil mustard induced lymphomas, pancreatic tumors, ovarian tumors, and mammary carcinomas (Refs. 37 and 46). Therefore, there is sufficient evidence for listing uracil mustard on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available carcinogenicity data for this chemical.  {Ov  70. Warfarin and salts (NA). Several studies in humans suggest that warfarin induces fetal death, and/or structural abnormalities in fetuses and newborns following oral exposure (doses as low as 8.4 mg/kg) or intramuscular injection (12 mg/kg). In mice, warfarin affected female fertility causing preimplantation mortality following intravenous injection (240 mg/kg). In rabbits, intravenous injection of warfarin (10 mg/kg) to pregnant does resulted in structural abnormalities of fetuses and stillbirth (Refs. 38 and 46). Therefore, there is sufficient evidence for listing warfarin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available reproductive/developmental toxicity data for this chemical.  {M C. Chemicals that Are Insufficient for Listing  {OH  EPA is not proposing to add those chemicals listed below to EPCRA section 313 because the available information does not indicate that these chemicals meet the toxicity criteria of section 313(d)(2). All chemicals are listed as RCRA hazardous wastes at 40 CFR 261.33(f) for toxicity only unless otherwise noted.  {O!  1. Acetyl chloride (CAS No. 00075 - 36 - 5). Acetyl chloride is listed at 40 CFR 261.33(f) for corrosivity, reactivity, and toxicity. Acetyl chloride hydrolyzes in moist air to acetic acid and hydrogen chloride. Acute toxicity data in humans indicate that inhalation of 2 ppm acetyl chloride is irritating to humans. Acetyl chloride is classified4#0*$$ as a Group D chemical by EPA; i.e., the compound is not classifiable as to human carcinogenicity based on the lack of human or animal data (Refs. 37 and 38). No data regarding the systemic toxicity of acetyl chloride could be located. Therefore, there is insufficient evidence for listing acetylchloride on EPCRA section 313 based on the available toxicity and carcinogenicity data for this chemical.  yO   Aquatic toxicity test data give measured 96 - hour LC50 values of 42 ppm for the fathead minnow (Refs. 3 and 41). Because this aquatic toxicity value is greater than 1 ppm and the BCF is less than 1,000, there is insufficient evidence for listing acetyl chloride on EPCRA section 313 based on available ecotoxicity information for this chemical.  {O@  2. Chloral (CAS No. 00075 - 87 - 6). In a mouse oral subchronic study, administration of chloral in water was associated with dose-related increased relative liver weights in males, increases in serum lactate dehydrogenase (LDH), serum glutamic oxalacetic transaminase (SGOT), microsomal cytochrome b5 content, aminopyrine N-demethylase, and aniline hydroxylase activities. These results suggest that the liver may be a target organ. However, no histopathology was performed and a NOAEL was not determined. The LOAEL was 15.7 mg/kg/day (Ref. 38). Therefore, there is insufficient evidence for listing chloral on EPCRA section 313 based on the available toxicity data for this chemical.  yO  Aquatic toxicity test data for chloral indicate a measured 48 - hour LC50 of 1,720 ppm for the golden orfe. The estimated acute aquatic toxicity value, using QSAR analysis based on the equation for aldehydes and a log P of 1.66, is approximately 12 ppm for fish, daphnid, and algae (Refs. 39 and 45). Because the measured and estimated aquatic acute toxicity values for chloral are greater than 1 ppm and the bioaccumulation potential is limited, based on the low log P value, there is insufficient evidence for listing chloral on EPCRA section 313 based on available ecotoxicity information for this chemical.  {Oj  3. 2-Chloroethyl vinyl ether (CAS No. 00110 - 75 - 8). Only limited data could be located regarding the acute  yO4 toxicity of 2-chloroethyl vinyl ether. The oral LD50 for the rat is 250 mg/kg (Ref. 37). No subchronic or chronic toxicity could be located. Therefore, there is insufficient evidence for including 2-chloroethyl vinyl ether on EPCRA section 313 based on the available toxicity data for this chemical.  yO  The measured aquatic toxicity test value for the bluegill 96 - hour LC50 is 350 ppm. Estimated aquatic toxicity  yOT values using the QSAR equation for neutral organics and log P of 0.99 are 703 ppm for fish 96 - hour LC50, 702  yO ppm for daphnid 48 - hour EC50, and 415 ppm for algae 96 - hour EC50 (Refs. 3 and 45). Because these aquatic toxicity values for 2-chloroethyl vinyl ether are greater than 1 ppm, there is insufficient evidence for listing 2-chloroethyl vinyl ether on EPCRA section 313 based on available ecotoxicity information for this chemical.  {Ot  4. b-Chloronaphthalene (CAS No. 00091 - 58 - 7). Dyspnea, abnormal appearance, and liver enlargement were  yO> observed in mice administered  -chloronaphthalene by gavage for 13 weeks. A LOAEL and NOAEL of 600 mg/kg/day and 250 mg/kg/day were determined, respectively. A supporting study also reported liver effects in rats injected with 80 mg/ kg/day -chloronaphthalene by the intraperitoneal route (Ref. 38). Chronic developmental and reproductive toxicity following oral exposure to -chloronaphthalene have not been tested. As - chloronaphthalene induced effects only at relatively high doses, there is insufficient evidence for listing this chemical on EPCRA section 313 based on the available toxicity data for this chemical.  yO  Estimated aquatic acute toxicity test data (48 - hour LC50) for daphnids is 10.1 to 23 mm/m3. Estimated aquatic toxicity values, based on QSAR analysis using the equation for neutral organics and a log P of 4.03, are between 1.3 and 1.8 ppm for fish, daphnid, and algae (Refs. 3 and 45). Because -chloronaphthalene has estimated aquatic acute toxicity values slightly greater than 1 ppm and its bioaccumulation potential is limited, based on a log P value of less than 5.5, there is insufficient evidence for listing -chloronaphthalene on EPCRA section 313 based on available ecotoxicity information for this chemical.  {Of"  5. Ethyl methacrylate (CAS No. 00097 - 63 - 2). Ethyl methacrylate causes irritation and CNS effects in humans (no dose levels available). In dogs, ethyl methacrylate administered intravenously increased respiratory rate, decreased0#0*$$ heart rate, produced electrocardiographic changes, and caused a biphasic response in blood pressure (Ref. 37); dose levels were not given. There is no carcinogenicity data on ethyl methacrylate. An NTP bioassay on methyl methacrylate, a close analogue, showed no evidence for carcinogenicity in rats and mice (Ref. 34). Therefore, there is insufficient evidence for including ethyl methacrylate on EPCRA section 313 based on the available toxicity data for this chemical and for its analogue, methyl methacrylate.  {O  6. Isobutyl alcohol (CAS No. 00078 - 83 - 1). Isobutyl alcohol is listed at 40 CFR 261.33(f) for ignitability and toxicity. In rats, isobutyl alcohol induced hypoactivity and ataxia following oral exposure, resulting in a NOAEL of 316 mg/kg/day and a LOAEL of 1,000 mg/kg/day (Ref. 38). As isobutyl alcohol induced effects only at relatively high doses, there is insufficient evidence for listing isobutyl alcohol on EPCRA section 313 based upon the available neurotoxicity data for this chemical.  yO  Aquatic toxicity test data for isobutyl alcohol indicate that measured acute values for fish 96 - hour LC50 range  yO from 1,330 to 1,600 ppm whereas the 48 - hour LC50 values for daphnids range from 1,060 to 1,350 ppm. Estimated aquatic toxicity values, based on QSAR analysis using the equation for neutral organics and a log P of 0.69, are 916  yO* ppm and 935 ppm for the fish 96 - hour and daphnid 48 - hour LC50, respectively, and 531.1 ppm for the algae 96  yO - hour EC50 (Refs. 3 and 45). Based on aquatic toxicity values for isobutyl alcohol that are consistently greater than 100 ppm and a very low log P value, there is insufficient evidence for listing isobutyl alcohol on EPCRA section 313 based on available ecotoxicity information for this chemical.  {OJ  7. Maleic hydrazide (CAS No. 00123 - 33 - 1). In rats, the monoethanolamine salt of maleic hydrazide (1,2-dihydro-3,6-pyridazinedione) induced maternal and fetal toxicity, and teratogenicity following dietary exposure in pregnant rats during gestation, resulting in a LOAEL of 3,000 mg/kg/day and a NOAEL of 1,500 mg/kg/day. Effects noted were increased resorptions, decreased mean fetal weight, and increased postimplantation loss. When exposure was continued through the lactation period, there was a delay in the pups' startle response. In pregnant rabbits, oral administration of potassium salt of maleic hydrazide induced fetal toxicity (malformed scapulae), resulting in a NOAEL of 100 mg/kg/day and a lowest- adverse-effect level (LOAEL) of 300 mg/kg/day (Ref. 28). As maleic hydrazide induced effects only at relatively high doses, there is insufficient evidence for listing maleic hydrazide on EPCRA section 313 based on the available developmental toxicity data for this chemical. Additional toxicity data are available from EPA/OPP's One-Liner data base, however, this is CBI under FIFRA.  {O  8. Methapyrilene (CAS No. 00091 - 80 - 5). There are some cancer data that suggest that methapyrilene induces liver tumors in rats by intubation and dietary exposures (Refs. 37 and 44). However, the available carcinogenicity data are insufficient for listing methapyrilene on EPCRA section 313. In humans, methapyrilene induces anticholinergic toxicity, hallucinations, delirium and confusion. Methapyrilene produces toxic psychosis which is temporary and benign. There are several reports of fatality due to oral exposures. The human data are generally taken from reports of overdoses and the exposure levels are not known. In dogs, intravenous injection of 40 mg/kg (only dose level administered) methapyrilene induced anticholinergic effects (Refs. 37 and 49). NOAEL and LOAEL values cannot be derived from the available data for methapyrilene. Therefore, there is insufficient evidence for listing methapyrilene on EPCRA section 313 based upon the available neurotoxicity data for this chemical.  {O  9. Methyl ethyl ketone peroxide (CAS No. 01338 - 23 - 4). Methyl ethyl ketone peroxide is listed at 40 CFR 261.33(f) based on reactivity and toxicity. Methyl ethyl ketone peroxide is currently under short-term test by NTP for sub-chronic toxicity. No chronic systemic, teratogenicity, or reproductive studies could be located in the available  yO literature for methyl ethyl ketone peroxide. The inhalation LC50 values for rats and mice are 200 ppm (1.4 mg/L) and  yO 170 ppm (1.2 mg/L) methyl ethyl ketone peroxide, respectively. The oral LD50 for rats is 484 mg/kg (Ref. 37). Therefore, there is insufficient evidence for listing methyl ethyl ketone peroxide on EPCRA section 313 based on the available toxicity data for this chemical.  {O0#  10. 1,4-Naphthoquinone (CAS No. 00130 - 15 - 4). In humans, 1,4-0#0*$$Ԍnaphthoquinone decreases the number of erythrocytes and sulfhydryl compounds and hemoglobin levels in the blood. The compound also depresses the phagocytic activity of leukocytes and induces methemoglobin and heinz bodies  {O formation in the blood. It was not reported whether these effects were noted in vitro and no exposure levels were reported for these effects. In rats, methemoglobin and heinz body formation, hemolytic anemia, and decreased total respiration were induced following acute (0.5 g/kg) and subchronic (0.3 g/kg) exposure to 1,4-naphthoquinone. The  yO route of exposure was not reported. The oral LD50 values for rats and guinea pigs are 190 mg/kg and 400 mg/kg 1,4-naphthoquinone, respectively (Refs. 37 and 46). Therefore, there is insufficient evidence for listing 1,4-naphthoquinone on EPCRA section 313 based on the available toxicity data for this chemical. The estimated aquatic toxicity values for 1,4-naphthoquinone, based on QSAR analysis using the equation for  yO  neutral organics and a log P of 1.12, are 788 ppm for the fish 96 - hour LC50, 794 ppm for the daphnid 48 - hour  yO LC50, and 472 ppm for the algae 96 - hour EC50 (Ref. 42). The aquatic acute toxicity values for 1,4-naphthoquinone are consistently greater than 100 ppm and the log P value is less than 5.5. 1,4- Naphthoquinone has moderate volatility and low solubility and is expected to biodegrade in soil (the half-life is 1.2 days) or water. Based on these aquatic toxicity, bioaccumulation, and persistence values, there is insufficient evidence for listing 1,4-naphthoquinone on EPCRA section 313 based on available ecotoxicity information for this chemical.  {O  11. n-Propylamine (CAS No. 00107 - 10 - 8). n-Propylamine is listed at 40 CFR 261.33(f) for ignitability and toxicity. In studies conducted on rats, mice, rabbits, and guinea pigs, n-propylamine induced CNS excitation followed by inhibition after exposure by the inhalation or oral routes (Ref. 37). Details of the study, including effective doses, were not reported. Therefore, there is insufficient evidence for listing n- propylamine on EPCRA section 313 based on available neurotoxicity data for this chemical.  yO  The measured aquatic toxicity test data for n-propylamine include a fathead minnow 96 - hour LC50 value of 308 ppm. Estimated aquatic toxicity values, based on QSAR analysis using the equation for aliphatic amines and a log  yO4 P of 0.39, are 175 ppm for the fish 96 - hour LC50, 10.5 ppm for the daphnid 48 - hour LC50, and 11.3 for the algae  yO 96 - hour EC50 (Refs. 3 and 45). Because the measured and estimated acute aquatic toxicity values for n-propylamine are consistently greater than 1 ppm and the log P value is less than 5.5, there is insufficient evidence for listing n-propylamine on EPCRA section 313 based on available ecotoxicity information for this chemical.  {OT  12. Resorcinol (CAS No. 00108 - 46 - 3). Resorcinol is classified as a Group 3 carcinogen by IARC; i.e., the compound is not classifiable as to its carcinogenicity in humans. There is inadequate evidence of carcinogenicity in animals, and no data are available in humans (Ref. 37). There was no evidence of carcinogenicity in mice and rats in NTP studies. Therefore, there is insufficient evidence for listing resorcinol on EPCRA section 313 based on the available carcinogenicity data for this chemical. In rats, no maternal toxicity or fetotoxicity was observed following oral exposure to resorcinol (12.5 to 500 mg/kg) (Ref.37). Therefore, there is insufficient evidence for listing resorcinol on EPCRA section 313 based on the available developmental toxicity data for this chemical. The measured aquatic toxicity test data for resorcinol range from 40 to greater than 100 ppm for the fish 96 -  yO^ hour LC50 and 900 ppb for the daphnid 96 - hour LC50. The estimated aquatic toxicity value for the fish 96 - hour  yO& LC50, based on QSAR analysis using the equation for substituted phenols and a log P of 0.81, is 84.7 ppm (Refs. 3 and 45). Because the estimated aquatic acute toxicity value for resorcinol is greater than 1 ppm and the log P value is considerably less than 5.5, there is insufficient evidence for listing resorcinol on EPCRA section 313 based on available ecotoxicity information for this chemical.  yO * V. Rationale for Listing 6  yO! 6  EPA is proposing to add the chemical substances identified in Unit IV.B of this preamble because these chemicals meet the statutory criteria for listing under section 313(d)(2) of EPCRA. These determinations and the specific toxic effects are set forth in Unit IV.B of this preamble and in the rulemaking record..#0*$$Ԍ yO ԙd  VI. Alternative Proposal: Manufacturing Volume Threshold 6  {M 6  A. Manufacturing Volume Threshold for Additions to the Section 313 List  {O   Alternatively, EPA is proposing to add to the EPCRA section 313 list only those chemicals and chemical categories which are identified above in Unit IV.B which are manufactured, imported or processed (per facility) in quantities greater than an annual manufacturing volume threshold to be set by EPA. The selection of this manufacturing volume threshold would be guided by the EPCRA section 313 (f) reporting thresholds [The EPCRA section 313 manufacture (includes import) and process thresholds are 25,000 pounds per year per facility]. EPA anticipates that the addition of those chemicals manufactured, imported, or processed in quantities less than the manufacturing volume threshold would not be expected to result in the submission of Form R reports. The Agency is specifically considering two different manufacturing volume thresholds for determining which  {Ob chemicals of the petitioned chemicals would not be added to the section 313 list. EPA is seriously considering an annual per facility manufacturing volume threshold of 25,000 pounds, which is the EPCRA section 313(f)(1)(B) manufacturing threshold for section 313 reporting. The Agency does not believe that the addition of chemicals to the EPCRA section 313 list of toxic chemicals that are either not manufactured, imported, or processed or are manufactured, imported, or processed in quantities less than 25,000 pounds would provide a benefit to the public. If these chemicals were added to the EPCRA section 313 list, it is unlikely that any EPCRA section 313 Form R reports would be submitted. EPA recognizes, however, that it is possible that some chemicals may be manufactured, imported, or processed per facility annually in quantities less than 25,000 pounds, yet may be used by one or more facilities in excess of 10,000 pounds annually, thus subjecting those facilities to the section 313(f)(1)(A) use-triggered reporting requirements. Therefore, EPA is also considering a manufacturing volume threshold of 10,000 pounds per facility. EPA specifically requests comment on which manufacturing volume threshold should be used in making determinations to add or not add petitioned chemicals to the EPCRA section 313 list. When addressing petitions of this type, EPA believes that it is important to focus on those toxic chemicals that will yield data for the public. As such, EPA strongly believes that the use of a manufacturing volume threshold in responding to petitions submitted under section 313(e) is appropriate and within the authority granted by EPCRA. Section 313(e)(2) requires EPA, in responding to a petition submitted by a State Governor, to either add the petitioned chemical(s) to the section 313 list in accordance with section 313(d)(2) or to publish an explanation of why the Administrator believes the chemical(s) does not meet the requirements of section 313(d)(2). Section 313(d)(2) provides that ``[a] chemical may be added if the Administrator determines, in his judgment, that there is  {O< sufficient evidence to establish any one [of the listed criteria].'' EPA does not interpret section 313(d)(2) to mandate  yO the addition of any chemical to the section 313 list, but, rather, gives the Agency discretion to do so (``A chemical  {O may be added if the Administrator determines ...'' emphasis added.), provided any one of the listed criteria are satisfied. In this instance, EPA's use of a manufacturing volume threshold is consistent with the section 313 list's purpose of generation of publicly available release data on listed chemicals and therefore a valid exercise of the Agency's discretion. In addition to production volume considerations, EPA is interested in receiving comment on other criteria, such as risk, that would be consistent with the statute that can be used to determine which chemicals should be added to the EPCRA section 313 list.  {M B. Annual Manufacturing Volume  {O!  EPA used a 25,000 pound annual per facility manufacturing volume threshold as a benchmark in researching chemical marketing data in an effort to identify those chemicals which would be subject to the 25,000 pound per facility manufacturing volume threshold option described above. Thus, the largest potential group of petitioned2#0*$$ chemicals which would be affected by the annual production volume threshold could be identified. EPA recognizes that the additions to the EPCRA section 313 list may be greater if a manufacturing volume threshold of 10,000 pounds per facility is chosen. Information regarding production and use for each of the chemicals which were determined to meet the listing  {O  criteria under EPCRA section 313(d)(2) is contained in the support document Economic Analysis of the Proposed  {O Addition of 70 Chemicals to the EPCRA Section 313 List of Toxic Chemicals (Ref. 2). For each chemical considered, both publicly-available and confidential information sources, i.e., Toxic Substance Control Act (TSCA) section 14 confidential business information (CBI), were reviewed in search of evidence of that chemical's recent manufacture, importation, or use. Information on the number of sites at which the chemical was likely to be found was also sought. For most chemicals, information was available to allow EPA to make a determination that a particular chemical was either manufactured for commercial distribution (manufactured, imported, or processed in excess of 25,000 pounds, annually) or manufactured, imported, or processed in limited volumes. In cases where commercial distribution was indicated, reliable market data disclosed annual manufacture or importation in exceedence of 25,000 pounds, as well as the number of sites where the chemical was likely to be found. For the purposes of preparing the Economic Analysis (Ref. 2), where TSCA section 14 CBI was the only reliable source of evidence of a chemical's manufacture/importation, data retrieved from the data base were aggregated so as to prevent disclosure. In other cases, the manufacture/ importation of a chemical was indicated, but only in relatively small amounts (typically for research purposes). Also, some chemicals were suspected as functioning only as intermediates, and no reliable data were available regarding manufacture/importation. For approximately 33 percent of the chemicals considered, no evidence could be found of manufacture, importation, or use, commercial or otherwise. EPA's preliminary finding is that such chemicals are not manufactured, processed, or imported, and no reporting activities would be anticipated to result were they added to the section 313 list at this time. EPA's analysis indicates that a subset of the 68 chemicals and 2 chemical categories proposed for addition to EPCRA section 313 consists of chemicals that are either (1) manufactured, imported, or processed in annual quantities greater than 25,000 pounds, and can be listed below without possibly revealing TSCA section 14 CBI or (2) those for which a determination and public disclosure of the chemicals annual manufacturing volume could not be made without possibly disclosing CBI in violation of TSCA section 14. For chemicals in the latter group, TSCA section 14 CBI may indicate annual production beneath the 25,000 pound threshold for each facility. However, EPA may not use TSCA section 14 CBI information to identify the manufacturing and/or import volume of a chemical if doing so would reveal CBI. Should manufacturers of any chemicals appearing on the following list believe CBI would demonstrate that it's facility manufactures, imports, or processes the chemical below the 25,000 pound annual level, the company may waive its claim to CBI protection. CBI waivers would allow EPA to disclose, for the purpose of applying the proposed manufacturing volume threshold option, that such a chemical is manufactured, imported, or processed in a quantity of less than 25,000 pounds annually. However, EPA would need to receive waivers from all manufacturers, importers, and processors of a given chemical before using TSCA section 14 CBI information, if doing so would disclose CBI in violation of TSCA section 14. Companies should note that they may limit any TSCA section 14 CBI waiver to EPA's use of such information for purposes of today's proposed manufacturing volume threshold option. In addition, companies may make any CBI waiver conditional on EPA taking final action on this proposal and not listing a specific chemical on the EPCRA section 313 list, pursuant to the proposed manufacturing volume option. Alternatively, manufacturers are encouraged to submit to the Agency any publicly available information which would support a finding that a chemical is manufactured, imported, or processed in quantities less than 25,000 pounds. TSCA section 14 CBI waivers should be submitted by [Insert date 60 days after date of  yO,# publication in the Federal Register ] to: TSCA Document Receipt Office (TS - 790), Office of Pollution Prevention,#0*$$ and Toxics, Environmental Protection Agency, Rm. ET - 005, 401 M St., SW., Washington, DC 20460. Comments should include the docket control number ``OPPTS - 400069.'' The following chemicals are manufactured, imported, or processed in quantities greater than 25,000 pounds per facility per year: Acetophenone (00098-86-2) Amitrole (00061-82-5) p-Chloro-m-cresol (00059-50-7) Bis(2-chloroethoxy)methane (00111-91-1) Crotonaldehyde (04170-30-3) 1,4-Dichloro-2-butene (00764-41-0) Dihydrosafrole (00094-58-6) Ethylenebisdithiocarbamic acid, salts and esters (NA) Ethylidene dichloride (00075-34-3) Formic acid (00064-18-6) Hydrogen sulfide (07783-06-4) Malononitrile (00109-77-3) Methacrylonitrile (00126-98-7) Methyl chlorocarbonate (00079-22-1) Methyl mercaptan (00074-93-1) 2-Methylpyridine (00109-06-8) 5-Nitro-o-toluidine (00099-55-8) Pentachloroethane (00076-01-7) Pronamide (23950-58-5) 1,1,1,2-Tetrachloroethane (00630-20-6) Thiram (00137-26-8) p-Toluidine (00106-49-0) The following chemicals are manufactured, imported, or processed in quantities less than 25,000 pounds: Benz[a]anthracene (00056-55-3) Benzo[a]phenanthrene (00218-01-9) Benzo[a]pyrene (00050-32-8) 4-Bromophenyl phenyl ether (00101-55-3) Carbonic difluoride (00353-50-4) Chlorambucil (00305-03-3) Cyclophosphamide (00050-18-0) Dibenzo(a,h)anthracene (00053-70-3) 1,2-Diethylhydrazine (01615-80-1) Diethylstilbestrol (00056-53-1) Fluoranthene (00206-44-0) Glycidylaldehyde (00765-34-4) Hexachlorophene (00070-30-4) Hexachloropropene (01888-71-7) Indeno[1,2,3-cd]pyrene (00193-39-5) Melphalan (00148-82-3) N-Nitrosopyrrolidine (00930-55-2)#0*$$Ԍ Paraldehyde (00123-63-7) Pentachlorobenzene (00608-93-5) Reserpine (00050-55-5) Streptozotocin (18883-66-4) Trypan blue (00072-57-1) Uracil mustard (00066-75-1) Warfarin and salts (NA) No information could be located that indicate that the following chemicals are manufactured, imported, or processed: Azaserine (00115-02-6) Benz[c]acridine (00225-51-4) Benzo[rst]pentaphene (00189-55-9) Chlornaphazine (00494-03-1) 4-Chloro-o-toluidine hydrochloride (03165-93-3) Daunomycin (20830-81-3) DDD (00072-54-8) DDT (00050-29-3) O,O-Diethyl-S-methyl dithiophosphate (03288-58-2) 7,12-Dimethylbenz[a]anthracene (00057-97-6) 1,2-Dimethylhydrazine (00540-73-8) Ethyl methanesulfonate (00062-50-0) Kepone (00143-50-0) Lasiocarpine (00303-34-4) 3-Methylcholanthrene (00056-49-5) Methylthiouracil (00056-04-2) MNNG (N-methyl-N'-nitro-N-nitrosoguanidine) (00070-25-7) Mitomycin C (00050-07-7) N-Nitrosodiethanolamine (01116-54-7) N-Nitroso-N-methylurethane (00615-53-2) Phenacetin (00062-44-2) 1,2,4,5-Tetrachlorobenzene (00095-94-3) 2,4,5-TP (Silvex) (00093-72-1) 1,3,5-Trinitrobenzene (00099-35-4) Nine of the chemicals listed above (benz[c]acridine, benz[a]anthracene, benzo[rst]pentaphene, benzo[a]phenanthrene, benzo[a]pyrene, dibenzo(a,h)anthracene, 7,12-dimethylbenz[a]anthracene, fluoranthene, and indeno[1,2,3-cd]pyrene) which either have manufacturing volumes less than 25,000 pounds or for which no information could be located on their production are components of coke oven emissions known as polycyclic organic compounds. Since these chemicals are generated primarily in coke ovens, it is not likely that individually any would exceed the 25,000 pound per facility manufacturing threshold. However, as a category these chemicals are expected to collectively exceed the 25,000 pound per facility manufacturing threshold. EPA requests comment on public sources of annual manufacturing information, other than those used in the economic support document (Ref. 2), that could be used by the Agency to determine the production volume of those chemicals listed in Unit IV.B of this preamble. #0*$$Ԍ yO   VII. Proposed TSCA Section 5(a)(2) Significant New Use Rule 6  {M 6  A. Statutory Authority  {O   This proposal is issued under section 5(a)(2) of the Toxic Substances Control Act (TSCA), 15 U.S.C. 2604(a)(2).  {M B. TSCA Section 5(a)(2) SNUR  {OB  EPA recognizes that there may be future production in excess of the annual manufacturing volume threshold of any of the chemicals that based on the manufacturing volume threshold option are not added to the section 313 list. If EPA elects to adopt the manufacturing volume threshold option in a final rule, the Agency intends to promulgate a significant new use rule (SNUR) under TSCA section 5(a)(2) that would cover the substances manufactured, imported, or processed in amounts less than the manufacturing volume threshold specified in that rule (i.e., 25,000 or 10,000 pounds per year). For the purposes of this proposed SNUR, however, a manufacturing threshold of 25,000 pounds is used. The SNUR would require persons to submit a significant new use notice to EPA at least 90 days before manufacturing, importing, or processing any of the following chemical substances or chemical category, in  yO amounts of 25,000 pounds or greater, per year, per facility, for any use: #dZ6X@K@#  CAS No. Name  101-55-3 4-Bromophenyl phenyl ether 353-50-4 Carbon oxyfluoride (Carbonic difluoride) 50-29-3 DDT 56-53-1 Diethylstilbestrol 62-50-0 Ethyl methanesulfonate 70-30-4 Hexachlorophene 1888-71-7 Hexachloropropene 56-49-5 3-Methylcholanthrene 56-04-2 Methylthiouracil 70-25-7 MNNG (N-methyl-N'-nitro-N- nitrosoguanidine) 50-07-7 Mitomycin C 1116-54-7 N-Nitrosodiethanolamine 615-53-2 N-Nitroso-N-methylurethane 930-55-2 N-Nitrosopyrrolidine 123-63-7 Paraldehyde 608-93-5 Pentachlorobenzene 62-44-2 Phenacetin 50-55-5 Reserpine 95-94-3 1,2,4,5-Tetrachlorobenzene 99-35-4 1,3,5-Trinitrobenzene 72-57-1 Trypan blue N/A Warfarin and salts  #]\  PC=P# For the category warfarin and salts, reporting under the SNUR would be triggered, for example, by the manufacture of 20,000 pounds of warfarin and 5,000 pounds of a warfarin salt at a given facility in any calendar year, for any use (or any combination of uses). However, the SNUR reporting thresholds would be determined separately for manufacturing, importing, and processing activities.# 0*$$Ԍ The chemical substances and chemical category which are included in this alternative are those that EPA believes are currently being manufactured, imported, or processed in amounts of less than 25,000 pounds per year per facility and that appear on the TSCA Inventory (the Inventory is a list of existing chemical substances compiled by EPA under TSCA section 8(b)). Accordingly, some substances identified in the EPCRA section 313 petition that appear to be in production in amounts less than 25,000 pounds per year per facility may be excluded from coverage under TSCA section 3(2)(B) because of their uses (e.g., as a pesticide under the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. section 136, et seq.)). EPA discusses possible means of tracking production for those substances in Unit VII.D. below.  {M C. SNUR Statutory and Regulatory Background  {O  Section 5(a)(2) of TSCA (15 U.S.C. 2604(a)(2)) authorizes EPA to determine that a use of a chemical substance is a ``significant new use.'' The Agency must make this determination by rule after considering all relevant factors, including those listed in TSCA section 5(a)(2). These factors include the volume of a chemical substance's production, the extent to which a use changes, the type, form, magnitude, or duration of exposure to it, and the reasonably anticipated manner of producing or otherwise managing the substance. Once EPA determines that a use of a chemical substance is a significant new use, section 5(a)(1)(B) of TSCA requires persons to submit a notice to EPA at least 90 days before they manufacture, import, or process the chemical substance for that use. Persons subject to a SNUR must comply with the same notice requirements and EPA regulatory procedures as submitters of premanufacture notices (PMNs) under section 5(a)(1)(A) of TSCA. In particular, these requirements include the information submission requirements of TSCA section 5(b) and (d)(1), the exemptions authorized by TSCA sections 5(h)(1), (2), (3), and (5), and the regulations at 40 CFR part 720. General regulatory provisions applicable to SNURs are codified at 40 CFR part 721, subpart A. EPA may take regulatory action under sections 5(e), 5(f), 6, or 7 of TSCA to control the activities for which it has received a SNUR notice. If EPA does not take  yO action, section 5(g) of TSCA requires EPA to explain in the Federal Register its reasons for not taking action. Persons who intend to export a chemical substance identified in a proposed or final SNUR are subject to the export notification provisions of TSCA section 12(b). The regulations that interpret section 12(b) appear at 40 CFR part 707. The export notification requirements of 40 CFR part 707 are triggered by this action. Should EPA determine it to be inappropriate to finalize the SNUR, the proposal will be withdrawn. In addition, should EPA select an annual manufacturing volume threshold lower than 25,000 pounds in a final rule (i.e., 10,000 pounds), the export notification would cease to apply to those chemicals in today's proposed SNUR which are not subject to a final SNUR.  {M D. Objectives and Rationale for the SNUR Alternative  {OZ  To determine what would constitute a significant new use of the chemical substances and chemical category that are the subjects of this proposal, EPA considered relevant information on the toxicity of the chemical substances, likely exposures associated with possible uses, and the relevant factors listed in section 5(a)(2) of TSCA. Based on these considerations, EPA intends to achieve the following objectives with regard to the significant new use that is presented in this alternative. EPA would want to ensure that: a. The Agency would receive notice of any company's intent to manufacture, import, or process per calendar year, per facility, for any use, the chemicals and chemical category listed under this alternative in amounts greater than the annual manufacturing volume threshold as discussed in Unit VI.A. b. The Agency would have prospective manufacturing, importing, and processing data available from the significant new use notice that would allow it to make informed decisions regarding any possible listing under section 313 of EPCRA of the chemicals and chemical category listed in this alternative.,#!0*$$Ԍ c. The Agency would have an opportunity to review and evaluate data submitted in a significant new use notice before the notice submitter begins manufacture, importation, or processing for a significant new use. d. The Agency would be able to regulate prospective manufacturers, importers, or processors of the chemicals and chemical category listed in this alterative before a significant new use occurs, provided that the degree of potential health and/or environmental risk, or the uncertainty about the risks, is sufficient to warrant such regulation. As discussed in Unit IV.B, EPA has concerns regarding the toxicity of the chemical substances and chemical category that would be included in the SNUR. Indeed EPA has proposed today to add each of these chemicals to the EPCRA section 313 list. EPA believes exposures to the substances listed in this proposal associated with manufacture, import, processing, use, and associated activities could increase should manufacture, import, or processing volumes equal or exceed an established manufacturing volume threshold (i.e., 25,000 or 10,000 pounds, per year, per facility). The notice that would be required by the SNUR would provide EPA with the opportunity to evaluate activities associated with the significant new use, and an opportunity to protect against unreasonable risks, if any, from exposure to the chemical substances which could result from the proposed significant new use. Additionally, the information submitted with a SNUR notice could be used by EPA to consider initiating a rulemaking under EPCRA section 313 to list the chemical substance or chemical category that was the subject of the significant new use notice, if appropriate.  {MH E. Other Means of Tracking of Future Production  {O  Should EPA adopt the alternative proposal as a final rule, the Agency would have available in addition to a TSCA SNUR, several existing regulatory mechanisms for tracking production of the unlisted chemicals, to determine if any exceed the annual manufacturing volume threshold in future years such that EPA could reasonably anticipate that section 313 release reports would be filed were the chemical on the section 313 list.  {O  1. FIFRA section 7 information. As stated in Unit VII.B, many of the chemicals identified in this proposal are solely pesticides for which the TSCA SNUR mechanism would be inappropriate. Section 7 of FIFRA (7 U.S.C.  {O section 136 et seq.), however, provides the Agency with annual production information on registered pesticides. EPA regulations implementing FIFRA section 7 (40 CFR part 167) require all manufacturers of pesticidal products (which includes pesticides, active ingredients, or devices) to submit an annual report detailing the amount of each type of pesticidal product manufactured, sold or distributed during the past year, and estimated to be manufactured, imported, or processed during the current year (40 CFR 167.85). Although information obtained from manufacturers under FIFRA section 7 is confidential, EPA may be able to use such information as an internal device for tracking the manufacturing volume of chemicals that would not be added to the EPCRA section 313 list under today's alternative proposal, without violating FIFRA's confidentiality provision. EPA requests comment on other sources of information for this purpose.  {O  2. Food, drug, and cosmetics information. A number of the chemicals in today's proposed action are excluded from coverage under TSCA section 5 because they meet the definition of ``food,'' ``food additive,'' ``drug,'' ``cosmetic,'' or ``device'' under the Federal Food, Drug, and Cosmetic Act (see TSCA section 3(2)(B)(vi)), and therefore cannot be subject to a SNUR. EPA requests comment on sources of annual manufacturing information on such chemicals which could be used by the Agency to track manufacturing volumes.  yOH +L VIII. Rulemaking Record 6  yO 6  The record supporting this proposed rule is contained in the docket number OPTS - 400069. All documents, including an index of the docket, are available in the TSCA Public Docket Office from 8 a.m. to noon and 1 p.m. to 4 p.m., Monday through Friday, excluding legal holidays. The TSCA Public Docket Office is located at EPA Headquarters, Rm. NE - G004, 401 M St., SW., Washington, DC 20460.0#"0*$$Ԍ yO ԙ'> IX. Request for Public Comment 6  yO 6  EPA welcomes comment on any aspect of today's Federal Register Notice. EPA requests specific comment as detailed in the following paragraphs. EPA requests public comment on this proposal to add 68 chemicals and 2 chemical categories to the list of chemicals subject to EPCRA section 313. EPA carried out a limited hazard assesment and thus is specifically requesting toxicity information on those chemicals in Unit IV.B of this preamble that have been identified as ``may be sufficient for listing'' and on the chemicals listed above in Unit IV.C of this preamble. EPA requests comment on the use of a manufacturing volume threshold to preclude the addition of chemicals to the EPCRA section 313 list, as described in Unit VI. In addition, EPA solicits comment on what manufacturing volume threshold (e.g., 25,000 or 10,000 pounds per year per facility) would be appropriate for making this determination. EPA requests comment on whether the following nine polycyclic organic compounds should be listed as a category rather than individually: benz[c]acridine, benz[a]anthracene, benzo[rst]pentaphene, benzo[a]phenanthrene, benzo[a]pyrene, dibenzo(a,h)anthracene, 7,12- dimethylbenz[a]anthracene, fluoranthene, and indeno[1,2,3-cd]pyrene. Because these chemicals are generated in coke ovens, it is not likely they would individually trigger the manufacturing threshold at any given facility. However, if listed as a category it is expected that such coincidental manufacture would exceed the 25,000 pound manufacturing threshold. EPA is aware that the information used to determine if a chemical is manufactured, imported, or processed in quantities greater than an established manufacturing volume threshold (e.g., 25,000 or 10,000 pounds) is limited. Thus, the Agency specifically requests any information on the production volume of those chemicals listed in Unit IV.B of this preamble. EPA also requests comment on the suitability of using a TSCA SNUR as a mechanism for the Agency to use in tracking the future production of those chemicals listed in Unit IV.B of this preamble that are manufactured in quantities less than the threshold discussed in Unit VI.B of this preamble. EPA notes that a SNUR will capture only those chemicals subject to TSCA. Production information on chemicals that are used as pesticides, drugs, or cosmetics will not be captured by a SNUR. EPA requests comment on the use of other regulatory mechanisms for obtaining production volume information. EPA requests comment on public sources of annual manufacturing information, other than those used in the economic support document (Ref. 2), that could be used by the Agency to determine the production volume of those chemicals listed in Unit IV.B of this preamble. This petition does not request that any action be taken under RCRA, and today's proposal should not be inferred as a proposed RCRA action or a request for comment on the list of hazardous wastes. Comments should be submitted to the address listed under the ADDRESSES unit at the front of this document. All comments must be submitted on or before November 9, 1992.  yO 0 X. References 6  yOx 6  (1) Allied Chemical Corp. 1978. Letter to U.S. EPA submitting a medical review of an incident that occurred in one of the plants involving the exposure of methyl mercaptan, dimethyl disulfide, and acetonitrile with attachment. U.S. EPA/OTS Public Files, Document No. 8EHQ-0578-0149. (2) Andrei, R. 1992. Economic Analysis of the Proposed Addition of 70 Chemicals to the EPCRA Section 313 List of Toxic Chemicals. (3) AQUIRE. 1992. Aquatic Information Retrieval. Baltimore, MD: Chemical Information System. (4) ATSDR. 1989. Toxicological Profile for DDE, DDT, DDD. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA.##0*$$Ԍ (5) ATSDR. 1989. Toxicological Profile for 1,1-Dichloroethene. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA. (6) ATSDR. 1992. Toxicological Profile for Methyl Mercaptan. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA. (7) Browning, E. 1965. Toxicity and Metabolism of Industrial Solvents. New York, NY: American Elsevier, 261-263. (8) EPA. 1977. Notice of Rebuttable Presumption Against Registration and Continued Registration of Pesticide Products Containing Ethylenebisdithiocarbamates. U.S. Environmental Protection Agency: Part III. (42 FR 40618; August 10, 1977). (9) EPA. 1977. Notice of Rebuttable Presumption Against Registration and Continued Registration of Pesticide Products Containing Pronamide. U.S. Environmental Protection Agency: Part III. (42 FR 25906; May 20, 1977). (10) EPA. 1979. Position Document 2/3: Pronamide. U.S. Environmental Protection Agency, Washington, DC. EPA/SPRD-80/68, PB 80-213911, 80. (11) EPA. 1979. Position Documents 1, 2 and 3: Preliminary Determination Concerning a Rebuttal Presumption Against Registration of Pesticide Products Containing Silvex. U.S. Environmental Protection Agency, Washington, DC. NTIS PB 80-213. (12) EPA. 1982. Chemical Hazard Information Profile: 2- Methylpyridine, Draft Report. U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC. (13) EPA. 1984. Health and Environmental Effects Profile for Toluidines. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH. ECAO-CIN-P044. (14) EPA. 1984. Health Effects Assessment for Benzo(a)pyrene. U.S. Environmental Protection Agency, Environmental Criteria and Assessment Office, Cincinnati, OH. EPA/540/1-86-022. (15) EPA. 1986. Risk Assessment for 1,4-Dichloro-2-butene. Prepared by U.S. Environmental Protection Agency, Office of Toxic Substances, Risk Analysis Branch, Washington, DC. (16) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Azaserine. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (17) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Benzamine, 4-Chloro-2-Methyl-, Hydrochloro. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (18) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Chlorambucil. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (19) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Cyclophosphamide. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (20) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of 7,12-Dimethylbenz(a)anthracene. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (21) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of 1,2-Dimethylhydrazine. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (22) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Ethyl Methanesulfonate. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (23) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Guanidine, N-Methyl-N'-Nitro-N-Nitroso-. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section#$0*$$ 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (24)EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Kepone. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (25) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Lasiocarpine. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (26) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of Methylthiouracil. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (27) EPA. 1988. Addendum to Evaluation of the Potential Carcinogenicity of N-Nitroso-N-Methylurethane. Prepared in support of Reportable Quantity Adjustment Pursuant to CERCLA Section 102. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Washington, DC. (28) EPA. 1988. Health Advisory: Maleic Hydrazide. U.S. Environmental Protection Agency, Office of Drinking Water, Washington, DC. (29) EPA. 1988. Health Advisory: Pronamide. U.S. Environmental Protection Agency, Office of Drinking Water, Washington, DC. (30) EPA. 1990. Suspended, Canceled, and Restricted Pesticides. U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, Washington, DC. (31) EPA. 1991. Memorandum from M. G. Zeeman, HERD, OPTS, USEPA to G. E. Timm, ECAD, OPTS, USEPA. Review of data submitted by Eastman Kodak Company to the United States Environmental Protection  yOh Agency under a testing consent order published in the Federal Register on Novemeber 9, 1989. U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, Washington, DC. (32) EPA. 1992. Draft Hazard Assessment Guidelines for Listing Chemicals on the Toxic Release Inventory. U.S. Environmental Protection Agency, Office of Toxic Substances, Washington, DC. (33) EPA. 1992. Ethylenebisdithiocarbamate: Position Document 4. U.S. Environmental Protection Agency,  yOP Washington, DC.: Part III. Federal Register (57 FR 7484; March 2, 1992) (34) EPA. 1992. Structure activity relationship analysis submitted by Dr. David Lai, U.S. Environmental Protection Agency, Health and Environmental Review Division, Oncology Branch, Washington, DC. (35) EPA. 1992. Support Document. Response to the New York Governor's Petition for Addition of 82 RCRA Chemicals to the Toxic Release Inventory. Prepared for Chemical Review and Evaluation Branch, HERD, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, DC. June 15, 1992. (36) Fogleman, R. W., Elsea, J. R., Paynter, O. E., Kundzins, W. 1955. Pesticide safety evaluation: Toxicity of trinitrobenzene-aniline complex, a rodent repellent. Agricultural and Food Chemistry. 3(11):939- 939. (37) HSDB. 1992. Hazardous Substances Data Bank. Bethesda, MD: National Institutes of Health, National Library of Medicine. (38) IRIS. 1992. Integrated Risk Information System. U.S. Environmental Protection Agency, Washington, DC. (39) ITC. 1989. Interagency Testing Committee. Information Review prepared by CRCS/Dynamac Corporation, Rockville, MD. (40) Jarabek, A. 1992. Letter and Attachments to Nancy Pate of the Office of Air Quality Planning and Standards, U.S. EPA on Acetophenone. (41) MSU. 1992. Quantitative Structure-Activity Relationships (QSAR) Analysis. Institute for Process Analysis. Montana State University. (42) NPIRS. 1992. National Pesticide Information Retrieval System. NPIRS version of U.S. Environmental Protection Agency, Office of Pesticide Programs, Pesticide Document Management System, Washington, DC. (43) NRC. 1977. Drinking Water and Health. National Research Council, Assembly of Life Sciences, Advisory#%0*$$ Center on Toxicology, Safe Drinking Water Committee. Washington, DC.: National Academy of Sciences, 613-620. (44) NTP. 1991. Chemical Status Report Produced from NTP Chemtrack System. National Toxicology Program, Division of Toxicology Research and Testing, Research Triangle Park, NC. (45) OTS/EEB. 1992. Quantitative Structure-Activity Relationships (QSAR) Analysis. Office of Toxic Substances, U.S. Environmental Protection Agency, Washington, DC. (46) RTECS. 1992. Registry Of Toxic Effects of Chemical Substances. Bethesda, MD: National Institutes of Health, National Library of Medicine. (47) Shepard, T. H. 1986. Catalogue of Teratogenic Agents. 5th edition. Baltimore, MD: The Johns Hopkins University Press. (48) SOSELS. 1986. Specific Organ System Exposure Levels. Prepared for the Office of Air Quality Planning and Standards, Pollution Assessment Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC. (49) Temple, A. R., English, P. H. 1979. Treatment of methapyrilene toxicity with physostigmine. Veterinarian Human Toxicol. 21(2):84-86.  yO #  XI. Regulatory Assessment Requirements 6  {M 6  A. Executive Order 12291  {O  Executive Order (E.O.) 12291 requires each federal agency to classify as ``major'' any rule likely to result in: (1) An annual effect on the economy of $100 million or more; or (2) A major increase in costs or prices for consumers, individual industries, Federal, State, or local government agencies, or geographic regions; or (3) Significant adverse effects on competition, investment, productivity, innovation, or on the ability of United States-based enterprises to compete with foreign-based enterprises in domestic and export markets. EPA's economic analysis estimates up to 4,611 additional reports entailing annual costs to EPA, industry, and States of about $6.9 million as a result of the proposed addition of the 68 chemicals and 2 chemical categories to the section 313 list of toxic chemicals. EPA anticipates that this proposed addition will not have a significant effect on competition, costs, or prices. Therefore, EPA has determined that this proposed rule is not ``major.'' Should the alternative proposal to set a 10,000 pound production volume threshold for listing be adopted, additional costs were not estimated to be significant. This result is due principally to two factors. First, the statutory reporting threshold of 25,000 pounds for manufacturers would still be in force, regardless of any volume criteria set for listing. Second, it is unlikely that more than a minimal number of additional user sites would be required to report (chemicals used in annual volumes of at least 10,000 pounds but manufactured in volumes less than 25,000 pounds would generate additional Form R reports under the 10,000 pound production volume criterion; such chemicals would not generate user reports under a 25,000 pound production volume cutoff for listing, because the chemicals would not be added the EPCRA section 313 list). Incremental costs attributable to the proposed SNUR and incremental costs attributable to a promulgated SNUR were considered but, due to the great uncertainty associated with the frequency of occurrence of potentially regulated activities, such costs could only be presented at the unit cost level. These estimates are discussed briefly below. Unit costs to industry associated with the proposed SNUR would result from export notifications required under TSCA section 12(b), and were estimated to be $65 for each exported chemical subject to the proposed SNUR, per foreign country, per year. Unit costs to EPA were estimated to be about $22. With regard to a promulgated SNUR, unit costs to industry were estimated to range between $2,000 and $10,000 for each significant new use notice or modification request prepared, while costs to EPA for issuing and administering the SNUR were estimated to be $2,000. [Incremental costs to industry in connection with a response not to engage in a significant new use could not be estimated.] As costs would only be incurred in the event that*#&0*$$ a chemical listed in the rule were manufactured, imported, or processed in excess of the listing threshold, and as such chemicals are currently not manufactured, imported, or processed in excess of 25,000 pounds, it is expected that any overall increase in incremental costs resulting from a promulgated SNUR would be small.  {M  B. Regulatory Flexibility Act  {O  The Regulatory Flexibility Act of 1980 requires each Federal agency to perform a Regulatory Flexibility Analysis for all rules that are likely to have a ``significant impact on a substantial number of small entities.'' 40 CFR part 372 exempts certain small businesses from reporting; specifically, those facilities with fewer than 10 full-time employees. This exclusion exempts about one-half of all manufacturing facilities in Standard Industrial Classification (SIC) codes 20 through 39 from section 313 reporting. Additionally, facilities which manufacture or process less than 25,000 pounds or otherwise use less than 10,000 pounds of these chemicals annually are not required to report for these chemicals. Therefore, EPA concludes that the rule is not likely to significantly impact a substantial number of small entities.  {M C. Paperwork Reduction Act  {OJ  OMB has approved the information collection requirements contained in this proposed rule under the provisions of the Paperwork Reduction Act, 44 U.S.C. 3501 et seq. and has assigned OMB control numbers 2070 - 0093 and 2070 - 0038. The public reporting burden for this collection of information is estimated to average 43 hours per response, including time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Chief, Information Policy Branch, PM-223, U.S. Environmental Protection Agency, 401 M St., SW., Washington, DC, 20460; and to the Office of Information and Regulatory Affairs, Office of Management and Budget, 726 Jackson Place NW., Washington, DC 20503, marked ``Attention: Desk Officer for EPA.''  yO . List of Subjects 6  {M< 6  40 CFR Part 372  {O  Community right-to-know, Environmental protection, Reporting and recordkeeping requirements, Toxic chemicals.  {M^ 40 CFR Part 721  {O  Chemicals, Environmental protection, Hazardous materials, Recordkeeping and reporting requirements, Significant new uses. Dated: August 31, 1991.  yO / Victor J. Kimm,  {M 6  h Acting Assistant Administrator, Office of Prevention, Pesticides and Toxic Substances.  {O! 6  Therefore it is proposed that 40 CFR Chapter I be amended as follows: 1. Subchapter J is amended in part 372 as follows: 2#'0*$$Ԍ yO ԙ-T PART 372--[AMENDED] 6  yO 6  a. The authority citation for part 372 would continue to read as follows:  yO   Authority : 42 U.S.C. 11013 and 11028. b. In 372.65 by adding chemicals to paragraph (a) alphabetically and to paragraph (b) by CAS No. sequence and to paragraph (c) by alphabetically adding the categories to read as follows:  yO  372.65 Chemicals and chemical categories to which this part applies.  yO`  * * * * *  yO(  (a) * * *#dZ6X@K@#  Chemical Name CAS No. Effective date  * * * * * * * Acetophenone 98-86-2 1/1/94 * * * * * * * Amitrole 61-82-5 1/1/94 * * * * * * * Azaserine 115-02-6 1/1/94 * * * * * * * Benz[c]acridine 225-51-4 1/1/94 * * * * * * * Benz[a]anthracene 56-55-3 1/1/94 * * * * * * * Benzo[rst]pentaphene 189-55-9 1/1/94 Benzo[a]phenanthrene 218-01-9 1/1/94 Benzo[a]pyrene 50-32-8 1/1/94 * * * * * * * Bis(2-chloroethoxy)methane 111-91-1 1/1/94 * * * * * * * 4-Bromophenyl phenyl ether 101-55-3 1/1/94 * * * * * * * Carbonic difluoride 353-50-4 1/1/94 * * * * * * * Chlorambucil 305-03-3 1/1/94 * * * * * * * Chlornaphazine 494-03-1 1/1/94 * * * * * * * p-Chloro-m-cresol 59-50-7 1/1/94 "$(0*$$Ԍ * * * * * * * 4-Chloro-o-toluidine 3165-93-3 1/1/94 hydrochloride * * * * * * * Crotonaldehyde 4170-30-3 1/1/94 * * * * * * * Cyclophosphamide 50-18-0 1/1/94 * * * * * * * Daunomycin 20830-81-3 1/1/94 DDD 72-54-8 1/1/94 DDT 50-29-3 1/1/94 * * * * * * * Dibenzo(a,h)anthracene 53-70-3 1/1/94 * * * * * * * 1,4-Dichloro-2-butene 764-41-0 1/1/94 * * * * * * * 1,2-Diethylhydrazine 1615-80-1 1/1/94 O,O-Diethyl-S- 3288-58-2 1/1/94 methyldithiophosphate * * * * * * * Diethylstilbestrol 56-53-1 1/1/94 * * * * * * * Dihydrosafrole 94-58-6 1/1/94 * * * * * * * 7,12-Dimethyl- 57-97-6 1/1/94 benz[a]anthracene * * * * * * * 1,2-Dimethylhydrazine 540-73-8 1/1/94 * * * * * * * Ethylidene dichloride 75-34-3 1/1/94 Ethyl methanesulfonate 62-50-0 1/1/94 * * * * * * * Fluoranthene 206-44-0 1/1/94 * * * * * * * Formic acid 64-18-6 1/1/94 * * * * * * * Glycidylaldehyde 765-34-4 1/1/94 * * * * * * * Hexachlorophene 70-30-4 1/1/94 Hexachloropropene 1888-71-7 1/1/94 * * * * * * * Hydrogen sulfide 7783-06-4 1/1/94 * * * * * * * Indeno[1,2,3-cd]pyrene 193-39-5 1/1/94 #)0*$$Ԍ * * * * * * * Kepone 143-50-0 1/1/94 Lasiocarpine 303-34-4 1/1/94 * * * * * * * Malononitrile 109-77-3 1/1/94 * * * * * * * Melphalan 148-82-3 1/1/94 * * * * * * * Methacrylonitrile 126-98-7 1/1/94 * * * * * * * Methyl chlorocarbonate 79-22-1 1/1/94 3-Methylcholanthrene 56-49-5 1/1/94 * * * * * * * Methyl mercaptan 74-93-1 1/1/94 * * * * * * * 2-Methylpyridine 109-06-8 1/1/94 * * * * * * * Methylthiouracil 56-04-2 1/1/94 * * * * * * * Mitomycin C 50-07-7 1/1/94 MNNG (N-methyl-N'-nitro-N- 70-25-7 1/1/94 nitrosoguanidine) * * * * * * * N-Nitrosodiethanolamine 1116-54-7 1/1/94 * * * * * * * N-Nitroso-N-methylurethane 615-53-2 1/1/94 * * * * * * * N-Nitrosopyrrolidine 930-55-2 1/1/94 5-Nitro-o-toluidine 99-55-8 1/1/94 * * * * * * * Paraldehyde 123-63-7 1/1/94 * * * * * * * Pentachlorobenzene 608-93-5 1/1/94 Pentachloroethane 76-01-7 1/1/94 * * * * * * * Phenacetin 62-44-2 1/1/94 * * * * * * * Pronamide 23950-58-5 1/1/94 * * * * * * * Reserpine 50-55-5 1/1/94 * * * * * * * Streptozotocin 18883-66-4 1/1/94 * * * * * * * 1,2,4,5-Tetrachlorobenzene 95-94-3 1/1/94#*0*$$Ԍ1,1,1,2-Tetrachloroethane 630-20-6 1/1/94 * * * * * * * Thiram 137-26-8 1/1/94 * * * * * * * p-Toluidine 106-49-0 1/1/94 * * * * * * * 2,4,5-TP (Silvex) 93-72-1 1/1/94 * * * * * * * 1,3,5-Trinitrobenzene 99-35-4 1/1/94 * * * * * * * Trypan blue 72-57-1 1/1/94 Uracil mustard 66-75-1 1/1/94 * * * * * * *  #]\  PC=P#  yOB  (b) * * *#dZ6X@K@#  CAS No. Chemical Name Effective Date  * * * * * * * 50-07-7 Mitomycin C 1/1/94 50-18-0 Cyclophosphamide 1/1/94 50-29-3 DDT 1/1/94 50-32-8 Benzo[a]pyrene 1/1/94 50-55-5 Reserpine 1/1/94 * * * * * * * 53-70-3 Dibenzo(a,h)anthrace 1/1/94 ne * * * * * * * 56-04-2 Methylthiouracil 1/1/94 * * * * * * * 56-49-5 3-Methylcholanthrene 1/1/94 56-53-1 Diethylstilbestrol 1/1/94 56-55-3 Benz[a]anthracene 1/1/94 * * * * * * * 57-97-6 7,12-Dimethyl- 1/1/94 benz[a]anthracene * * * * * * * 59-50-7 p-Chloro-m-cresol 1/1/94 * * * * * * * 61-82-5 Amitrole 1/1/94 62-44-2 Phenacetin 1/1/94 62-50-0 Ethyl 1/1/94 methanesulfonate"$+0*$$Ԍ * * * * * * * 64-18-6 Formic acid 1/1/94 * * * * * * * 66-75-1 Uracil mustard 1/1/94 * * * * * * * 70-25-7 MNNG (N-methyl-N'- 1/1/94 nitro-N- nitrosoguanidine) 70-30-4 Hexachlorophene 1/1/94 * * * * * * * 72-54-8 DDD 1/1/94 72-57-1 Trypan blue 1/1/94 * * * * * * * 74-93-1 Methyl mercaptan 1/1/94 * * * * * * * 75-34-3 Ethylidene 1/1/94 dichloride * * * * * * * 76-01-7 Pentachloroethane 1/1/94 * * * * * * * 79-22-1 Methyl 1/1/94 chlorocarbonate * * * * * * * 93-72-1 2,4,5-TP(Silvex) 1/1/94 * * * * * * * 94-58-6 Dihydrosafrole 1/1/94 * * * * * * * 95-94-3 1,2,4,5- 1/1/94 Tetrachlorobenzene 98-86-2 Acetophenone 1/1/94 * * * * * * * 99-35-4 1,3,5- 1/1/94 Trinitrobenzene 99-55-8 5-Nitro-o-toluidine 1/1/94 * * * * * * * 101-55-3 4-Bromophenyl phenyl 1/1/94 ether * * * * * * * 106-49-0 p-Toluidine 1/1/94 * * * * * * * 109-06-8 2-Methylpyridine 1/1/94 109-77-3 Malononitrile 1/1/94 * * * * * * * 111-91-1 Bis(2- 1/1/94 chloroethoxy)methan e #,0*$$Ԍ * * * * * * * 115-02-6 Azaserine 1/1/94 * * * * * * * 123-63-7 Paraldehyde 1/1/94 * * * * * * * 126-98-7 Methacrylonitrile 1/1/94 * * * * * * * 137-26-8 Thiram 1/1/94 * * * * * * * 143-50-0 Kepone 1/1/94 148-82-3 Melphalan 1/1/94 * * * * * * * 189-55-9 Benzo[rst]pentaphene 1/1/94 193-39-5 Indeno[1,2,3-cd]pyre 1/1/94 ne 206-44-0 Fluoranthene 1/1/94 218-01-9 Benzo[a]phenanthrene 1/1/94 225-51-4 Benz[c]acridine 1/1/94 * * * * * * * 303-34-4 Lasiocarpine 1/1/94 305-03-3 Chlorambucil 1/1/94 * * * * * * * 353-50-4 Carbonic difluoride 1/1/94 * * * * * * * 494-03-1 Chlornaphazine 1/1/94 * * * * * * * 540-73-8 1,2- 1/1/94 Dimethylhydrazine * * * * * * * 608-93-5 Pentachlorobenzene 1/1/94 * * * * * * * 615-53-2 N-Nitroso-N- 1/1/94 methylurethane * * * * * * * 630-20-6 1,1,1,2- 1/1/94 Tetrachloroethane * * * * * * * 764-41-0 1,4-Dichloro-2- 1/1/94 butene 765-34-4 Glycidylaldehyde 1/1/94 * * * * * * * 930-55-2 N-Nitrosopyrrolidine 1/1/94 * * * * * * * 1116-54-7 N- 1/1/94 Nitrosodiethanolami ne #-0*$$Ԍ * * * * * * * 1615-80-1 1,2-Diethylhydrazine 1/1/94 * * * * * * * 1888-71-7 Hexachloropropene 1/1/94 * * * * * * * 3165-93-3 4-Chloro-o-toluidine 1/1/94 hydrochloride 3288-58-2 O,O-Diethyl-S-methyl 1/1/94 dithiophosphate * * * * * * * 4170-30-3 Crotonaldehyde 1/1/94 * * * * * * * 7783-06-4 Hydrogen sulfide 1/1/94 * * * * * * * 18883-66-4 Streptozotocin 1/1/94 * * * * * * * 20830-81-3 Daunomycin 1/1/94 23950-58-5 Pronamide 1/1/94 * * * * * * *  #]\  PC=P#  yO\  (c) * * *#dZ6X@K@#  Category Name Effective Date  * * * * * Ethylenebisdithiocarbamic acid, salts and esters 1/1/94 * * * * * Warfarin and salts 1/1/94 * * * * *  #]\  PC=P# 2. Subchapter R is amended in part 721 as follows:  yO: -T PART 721--[AMENDED] 6  yO! 6  a. The authority citation for part 721 would continue to read as follows:  yOZ#  Authority : 15 U.S.C. 2604, 2607 and 2625(c).Z#.0*$$Ԍ b. By adding new 721.1430 to subpart E to read as follows:  yOX   721.1430 Pentachlorobenzene.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance pentachlorobenzene (CAS No. 608 - 93-5) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {Od  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] c. By adding new 721.1435 to subpart E to read as follows:  yO  721.1435 1,2,4,5-Tetrachlorobenzene.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance 1,2,4,5-tetrachlorobenzene (CAS No. 95 - 94 - 3) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O"  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] d. By adding new 721.1440 to subpart E to read as follows:  yO  721.1440 1,3,5-Trinitrobenzene.  {Od  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance 1,3,5-trinitrobenzene (CAS No. 99 - 35 - 4) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {ON  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] e. By adding new 721.2084 to subpart E to read as follows::#/0*$$Ԍ  yO  721.2084 Carbon oxyfluoride (Carbonic difluoride).  {OX  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance carbon oxyfluoride (CAS No. 353 - 50 - 4) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {OB  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] f. By adding new 721.2092 to subpart E to read as follows:  yO  721.2092 3 - Methylcholanthrene.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance 3 - methylcholanthene (CAS No. 56 - 49 - 5) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] g. By adding new 721.2287 to subpart E to read as follows:  yOD  721.2287 DDT.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance DDT (CAS No. 50 - 29 - 3) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {OP  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] h. By adding new 721.2355 to subpart E to read as follows: :#00*$$Ԍ yO  721.2355 Diethylstilbestrol.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance diethylstilbestrol (CAS No. 56 - 53 - 1) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {Oz  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O   (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] i. By adding new 721.3350 to subpart E to read as follows:  yO  721.3350 N-Nitrosodiethanolamine.  {ON  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance N-nitrosodiethanolamine (CAS No. 1116 - 54 - 7) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O8  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance:  721.125(a), (b), and (c). (2) [Reserved] j. By adding new  721.3430 to subpart E to read as follows:  yO|  721.3430 4-Bromophenyl phenyl ether.  {O   (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance 4-bromophenyl phenyl ether (CAS No. 101 - 55 - 3) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance:  721.125(a), (b), and (c). (2) [Reserved] k. By adding new  721.4080 to subpart E to read as follows:  yO:#  721.4080 MNNG (N-methyl-N'-nitro-N-nitrosoguanidine).:#10*$$Ԍ {O ԙ (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance MNNG (N-methyl-N'-nitro-N- nitrosoguanidine) (CAS No. 70 - 25 - 7) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {OD  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] l. By adding new 721.4150 to subpart E to read as follows:  yO  721.4150 Hexachlorophene.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance hexachlorophene (CAS No. 70 - 30 - 4) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {Op  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] m. By adding new 721.4155 to subpart E to read as follows:  yO  721.4155 Hexachloropropene.  {OD  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance hexachloropropene (CAS No. 1888 - 71 - 7) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O.  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance:  721.125(a), (b), and (c). (2) [Reserved] n. By adding new 721.5175 to subpart E to read as follows:  yOr"  721.5175 Mitomycin C. :#20*$$Ԍ {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance mitomycin C (CAS No. 50 - 07 - 7) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O|  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] o. By adding new 721.5640 to subpart E to read as follows:  yO.  721.5640 Paraldehyde.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance paraldehyde (CAS No. 123 - 63 - 7) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O:  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] p. By adding new 721.5710 to subpart E to read as follows:  yO  721.5710 Phenacetin.  {O|  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance phenacetin (CAS No. 62 - 44 - 2) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {Of  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] q. By adding new 721.9000 to subpart E to read as follows:  yO!  721.9000 N-Nitrosopyrrolidine.  {O:#  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance:#30*$$ N-nitrosopyrrolidine (CAS No. 930 - 55 - 2) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O   (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] r. By adding new 721.9470 to subpart E to read as follows:  yOd  721.9470 Reserpine.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance reserpine (CAS No. 50 - 55 - 5) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {Op  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance:  721.125(a), (b), and (c). (2) [Reserved] s. By adding new 721.9660 to subpart E to read as follows:  yO"  721.9660 Methylthiouracil.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance methylthiouracil (CAS No. 56 - 04 - 2) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O.  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] t. By adding new 721.9957 to subpart E to read as follows:  yO  721.9957 N-Nitroso-N-methylurethane.  {Op"  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance N-nitroso-N-methylurethane (CAS No. 615 - 53 - 2) is subject to reporting under this section for the significant new:#40*$$ use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {OX  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] u. By adding new 721.9580 to subpart E to read as follows:  yO  721.9580 Ethyl methanesulfonate.  {O,  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance ethyl methanesulfonate (CAS No. 62 - 50 - 0) is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {O  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance: 721.125(a), (b), and (c). (2) [Reserved] v. By adding new 721.9967 to subpart E to read as follows:  yOZ  721.9967 Warfarin and salts.  {O  (a) Chemical substance and significant new use subject to reporting. (1) The chemical substance warfarin and its salts is subject to reporting under this section for the significant new use described in paragraph (a)(2) of this section. (2) The significant new use is: Manufacture, import, or processing of 25,000 pounds or more per year per facility for any use.  {O  (b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph.  {Of  (1) Recordkeeping. The following recordkeeping requirements are applicable to manufacturers, importers, and processors of this substance:  721.125(a), (b), and (c). (2) [Reserved] [FR Doc. 92 - 21534 Filed 9 - 4 - 92; 8:45 am]  yOP  BILLING CODE 6560 - 50 - F