The Registry of Toxic Effects of Chemical Substances
m - Xylene |
UPDATE: May 2008 | MW: 106.18 | MF: C8H10 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
5 mg/24 hour
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severe
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85JCAE -,30,1986
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skin | rat
1,00%/1 hour
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TOXID9 72,379,2003
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skin | rabbit
10 µg/24 hour open irritation test
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severe
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AIHAAP 23,95,1962
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skin | rabbit
20 mg/24 hour
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moderate
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85JCAE -,30,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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DNA damage
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human
fibroblast
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0.34 mmol/L/1 hour
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TOLED5 147,35,2004
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lowest published toxic concentration: 500 mg/m3/12 hour (6-15 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
ATSUDG 8,425,1985
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inhalation | rat
lowest published toxic concentration: 3,000 mg/m3/24 hour (7-14 day pregnant)
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Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 18,61,1980
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inhalation | rabbit
lowest published toxic concentration: 500 mg/m3/24 hour (7-20 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetal death
ATSUDG 8,425,1985
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oral | mouse
lowest published toxic dose: 12 mg/kg (12-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
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APTOD9 19,A22,1980
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oral | mouse
lowest published toxic dose: 30 mg/kg (6-15 day pregnant)
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Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
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APTOD9 19,A22,1980
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | human
lowest published toxic concentration: 50 ppm/2 hour
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Brain and Coverings: Other degenerative changes | Liver: Other changes Biochemical: Metabolism (intermediary): Other
TOXID9 60,428,2001
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inhalation | mammal (species unspecified)
lowest published toxic concentration: 300 ppm
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Lung, Thorax, or Respiration: Other changes | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 66,97,2002
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inhalation | man
lowest published toxic concentration: 424 mg/m3/6 hour/6 day
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Behavioral: Change in motor activity (specific assay)
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TOLED5 1000(Sp Iss 1),74,1980
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inhalation | man
lowest published toxic concentration: 870 mg/m3/4 hour- intermittent
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Behavioral: Ataxia | Behavioral: Irritability
ATSUDG 7,412,1984
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inhalation | mouse
lowest published lethal concentration: 2,010 ppm/24 hour
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N/R
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JPBAA7 46,95,1938
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inhalation | mouse
lethal concentration (50 percent kill): 5,267 ppm/6 hour
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N/R
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VCVGH* -,159,1990
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inhalation | rat
lowest published lethal concentration: 8,000 ppm/4 hour
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N/R
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AIHAAP 23,95,1962
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inhalation | rat
lowest published toxic dose: 100 ppm/6 hour
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Olfaction: Other olfaction effects | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
INHTE5 16,125,2004
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inhalation | rat
lowest published toxic dose: 300 ppm/6 hour
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Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
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INHTE5 16,125,2004
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inhalation | rat
lowest published toxic concentration: 100 ppm/6 hour
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Olfaction: Other olfaction effects | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
INHTE5 16,125,2004
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inhalation | rat
lowest published toxic concentration: 300 ppm/6 hour
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Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
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INHTE5 16,125,2004
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intraperitoneal | mammal (species unspecified)
lowest published lethal dose: 2 gm/kg
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N/R
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JPBAA7 46,95,1938
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intraperitoneal | mouse
lethal dose (50 percent kill): 2,003 µL/kg
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N/R
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ARTODN 58,106,1985
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oral | rat
lethal dose (50 percent kill): 4,988 mg/kg
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N/R
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VCVGH* -,160,1990
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subcutaneous | mammal (species unspecified)
lowest published lethal dose: 5 gm/kg
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N/R
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JPBAA7 46,95,1938
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skin | guinea pig
lowest published toxic dose: 500 µL/kg/1 hour
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Skin: After topical application: Primary irritation
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TOXID9 1,59,2001
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skin | rat
lowest published toxic dose: 0.92 mL/kg
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Skin: After topical application: Primary irritation | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Biochemical: Metabolism (intermediary): Other proteins
ARTODN 79,294,2005
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skin | rat
lowest published toxic dose: 1,250 µL/kg/1 hour
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Skin: After topical application: Primary irritation
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TOXID9 1,59,2001
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skin | rabbit
lethal dose (50 percent kill): 14,100 µL/kg
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N/R
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AIHAAP 23,95,1962
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent
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Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ARTODN 45,117,1980
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inhalation | rat
lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent
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Behavioral: Analgesia | Behavioral: Alteration of operant conditioning Behavioral: Alteration of classical conditioning
NRTXDN 22,79,2001
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inhalation | rat
lowest published toxic concentration: 1,000 ppm/6 hour/8 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Behavioral: Food intake (animal)
FCTOD7 41,415,2003
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oral | rat
lowest published toxic dose: 10 gm/kg/4 week- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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TIHEEC 1(3),67,1985
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skin | rat
lowest published toxic dose: 0.96 mL/kg/4 day- intermittent
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Skin: After topical application: Primary irritation | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Biochemical: Metabolism (intermediary): Other proteins
ARTODN 79,294,2005
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REVIEWS:
ORGANIZATION
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STANDARD
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| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 100 ppm;short term exposure limit 150 ppm
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DTLVS* TLV/BEI,2007
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not classifiable as human carcinogen
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DTLVS* TLV/BEI,2007
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Inadequate Evidence
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IMEMDT 71,1189,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMEMDT 71,1189,1999
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMEMDT 71,1189,1999
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TOXICOLOGY REVIEW
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TOLED5 127,111,2002
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TOXICOLOGY REVIEW
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ENTOX* -,470,2005
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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| REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 100 ppm (440 mg/m3) (skin)
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DTLVS* 3,281,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 100 ppm (435 mg/m3)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 100 ppm (435 mg/m3)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 100 ppm (435 mg/m3)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 100 ppm (435 mg/m3)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - DENMARK
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time-weighted average 25 ppm (109 mg/m3), OCT 2002
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Occupational Exposure Limit - EC
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time-weighted average 221 mg/m3 (50 ppm); | short term exposure limit 442 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FRANCE
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VME 50 ppm (221 mg/m3), VLE 100 ppm (442 mg/m3), Skin, FEB2006
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Occupational Exposure Limit - GERMANY
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MAK 440 mg/m3 (100 mL/m3), 2005
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 50 ppm (217 mg/m3), APR2007
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Occupational Exposure Limit - MEXICO
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time-weighted average 100 ppm (435 mg/m3); | short term exposure limit 150 ppm (655 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND
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time-weighted average 50 ppm (217 mg/m3), JAN2002
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Occupational Exposure Limit - NORWAY
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time-weighted average 25 ppm (108 mg/m3), JAN1999
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Occupational Exposure Limit - SWEDEN
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time-weighted average 50 ppm (200 mg/m3); | short term exposure limit 100 ppm (450 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND
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MAK- week 100 ppm (435 mg/m3),KZG- week 200 ppm (870 mg/m3),Skin, DEC2006
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 50 ppm (220 mg/m3); |
short term exposure limit 100 ppm (skin), 2005 |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-XYLENE-air
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10 hour time-weighted average 100 ppm; | short term exposure limit 150 ppm
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: M1027; | Number of Industries 5; Total Number of Facilities 96; Number of Occupations 21; Total Number of Employees Exposed 4,621
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: M1027 |
![]() Number of Industries 33; Total Number of Facilities 4,113; Number of Occupations 36; Total Number of Employees Exposed 39,864; Total Number of Female Employees Exposed 7,449 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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| REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
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FEREAC 47,26992,82
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Used as intermediate in preparation of ISOPHTHALIC ACID
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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OSHA ANALYTICAL METHOD #1002
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REFERENCES:
CODEN
|
| REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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APTOD9
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Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802)
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ARTODN
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Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
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ATSUDG
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Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way, Secaucus, NJ 07094) No.1- 1978-
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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ENTOX*
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Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
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FCTOD7
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Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.20- 1982-
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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INHTE5
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Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P
4EE) V.1- 1989-
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JPBAA7
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Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher
information, see JPTLAS.
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NRTXDN
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Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
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TIHEEC
|
Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ
08540) V.1- 1985-
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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VCVGH*
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"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
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