New article, “The Key to Your Health”, published in the Summer 2008 issue of AARP SegundJuventud. See quotes by Dr. Rodolfo Valdez, Epidemiologist, National Office of Public Health Genomics, CDC, and other experts.
	The U.S. Department of Health and Human Services considers adding genetic information to electronic health records . Read a related HHS press release.
	What's New in HuGENet™ June 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
A new cell line expressing a novel type of TMPRSS2-ERG gene fusion derived from primary tumors of familial prostate cancer patient, Medical News Today, June 12	The high-resolution genomic profiling using whole-genome single nucleotide polymorphism genotyping in clear cell renal cell carcinoma, Medical News Today, June 11
Cancer risk factors to be studied in large-scale study, cbc.ca, June 11	More opt for preventive surgery, BBC News, June 9
The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population, 7th Space, June 11	Pitt researchers identify gene that influences damage from radiation therapy, Medical News Today, June 9
Novel therapeutic strategy for colon cancer treatment, Medical News Today, June 11	MicroRNA expression profile in clear-cell kidney cancer, Medical News Today, June 8
Outing the outliers: Strategy matches oncogene with subtype of prostate cancer, Science Daily, June 11

Synthesis of genetic association studies for pertinent gene-disease associations  requires appropriate methodological and statistical approaches Zintzaras E & Lau J J Clin Epidemiol 2008 Jul;61(7):634-45

Genetic association analysis: a primer on how it works, its strengths and its weaknesses
Rodriguez-Murillo L & Greenberg DA
Int J Androl 2008 Jun

The search for genes contributing to endometriosis risk
Montgomery GW, et al.
Hum Reprod Update 2008 Jun

Depression and the serotonin transporter 5-HTTLPR polymorphism: A review and a hypothesis concerning gene-environment interaction
Brown GW & Harris TO
J Affect Disord 2008 Jun

PRODH variants and risk for schizophrenia
Willis A, et al.
Amino Acids 2008 Jun

Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease
Rudkowska I & Jones PJ
Nutr Rev 2008 Jun;66(6):343-8

Management of colorectal cancer: A role for genetics in prevention and treatment?
Sengupta N, et al.
Pathol Res Pract 2008 Jun

Gene-environment interactions for complex traits: definitions, methodological requirements and challenges
Dempfle A, et al.
Eur J Hum Genet 2008 Jun

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
Oksenberg JR, et al.
Nat Rev Genet 2008 Jun

Genetic basis of ventricular arrhythmias
Boussy T, et al.
Cardiol Clin 2008 Aug;26(3):335-53

Phenotypic Variants of the Deafness-Associated Mitochondrial DNA A7445G Mutation
Maasz A, et al.
Curr Med Chem 2008;15(13):1257-62

Genetics of Sarcoidosis
Muller-Quernheim J, et al.
Clin Chest Med 2008 Sep;29(3):391-414

Estimation and testing of gene-environment interactions in family-based association studies
Cordell HJ
Genomics 2008 Jun

Polymorphisms in the IGF1 and IGF1R genes and children born small for gestational age: results of large population studies
Ester WA & Hokken-Koelega AC
Best Pract Res Clin Endocrinol Metab 2008 Jun;22(3):415-31

Prevalence, Family History, and Prevention of Reported Osteoporosis in U.S. Women
Robitaille J, et al.
Am J Prev Med 2008 Jul;35(1):47-54

Association of family history with cancer recurrence and survival among patients with stage III colon cancer
Chan JA, et al.
JAMA 2008 Jun;299(21):2515-23

Benign Breast Disease among First-Degree Relatives of Young Breast Cancer Patients
Bertelsen L, et al.
Am J Epidemiol 2008 Jun

Family history of cardiovascular disease does not predict risk-reducing behavior
Elis A, et al.
Eur J Cardiovasc Prev Rehabil 2008 Jun;15(3):325-8

 

Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy
Olivotto I, et al.
Mayo Clin Proc 2008 Jun;83(6):630-8

 

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
Cooper GM, et al.
Blood 2008 Jun

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 11, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
 

For more information on HuGE, please visit the HuGENet™ home page