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Lymphatic Filariasis

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CDC Publications on Lymphatic Filariasis


Diagnosis and Treatment

Dreyer G, Addiss D, Gadelha P, Lapa E, Williamson J, Dreyer A. Interdigital skin lesions of the lower limbs among patients with lymphoedema in an area endemic for bancroftian filariasis. Trop Med Internat Health. 2006;11:1475-1481.

Dreyer G, Addiss D, Williamson J, Norões J. Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti. Trans Roy Soc Trop Med Hyg. 2006;100:1118-1125.

McPherson T, Persaud S, Singh S, Fay MP, Addiss D, Nutman TB, et al. Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area. Br J Dermatol. 2006 May;154(5):933-41.

Critchley J, Addiss D, Gamble C, Garner P, Gelband H, Ejere H. Albendazole for lymphatic filariasis. International Filariasis Review Group. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD003753. Review.

Fox LM, Wilson SF, Addiss DG, Louis-Charles J, Beau de Rochars MV, Lammie PJ. Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions. Am J Trop Med Hyg. 2005 Oct;73(4):759-65.

Critchley J, Addiss D, Ejere H, Gamble C, Garner P, Gelband H. Albendazole for the control and elimination of lymphatic filariasis: systematic review. International Filariasis Review Group. Trop Med Int Health. 2005 Sep;10(9):818-25. Review.

Fox LM, Furness BW, Haser JK, Desire D, Brissau JM, Milord MD, et al. Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. Am J Trop Med Hyg. 2005 Jul;73(1):115-21.

Fox LM, Furness BW, Haser JK, Brissau JM, Louis-Charles J, Wilson SF, et al. Ultrasonographic examination of Haitian children with lymphatic filariasis: a longitudinal assessment in the context of antifilarial drug treatment. Am J Trop Med Hyg. 2005 May;72(5):642-8.

Addiss DG, Mackenzie C. LF disease – Clinical management. Am J Trop Med Hyg. 2004;71(suppl):12-15.

Wilson SF, Guarner J, Valme AL, Louis-Charles J, Jones TL, Addiss DG. Histopathologic improvement with lymphedema management, Leogane, Haiti. Emerg Infect Dis. 2004 Nov;10(11):1938-46.

Noroes J, Addiss D, Cedenho A, Figueredo-Silva J, Lima G, Dreyer G. Pathogenesis of filarial hydrocele: risk associated with intrascrotal nodules caused by death of adult Wuchereria bancrofti. Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):561-6.

Baird JB, Charles JL, Streit TG, Roberts JM, Addiss DG, Lammie PJ. Reactivity to bacterial, fungal, and parasite antigens in patients with lymphedema and elephantiasis. Am J Trop Med Hyg. 2002 Feb;66(2):163-9.

Horton J, Witt C, Ottesen EA, Lazdins JK, Addiss DG, Awadzi K, et al. An analysis of the safety of the single dose, two drug regimens used in programmes to eliminate lymphatic filariasis. Parasitology. 2000;121 Suppl: S147-60. Review.

Schuetz A, Addiss DG, Eberhard ML, Lammie PJ. Evaluation of the whole blood filariasis ICT test for short-term monitoring after antifilarial treatment. Am J Trop Med Hyg. 2000 Apr;62(4):502-3.

Dreyer G, Santos A, Noroes J, Addiss D. Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis. Trop Med Int Health. 1999 Aug;4(8):575-9.

Dreyer G, Noroes J, Addiss D, Santos A, Medeiros Z, Figueredo-Silva J. Bancroftian filariasis in a paediatric population: an ultrasonographic study. Trans R Soc Trop Med Hyg. 1999 Nov-Dec;93(6):633-6.

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Epidemiology and Public Health

Person B, Addiss DG, Bartholomew LK, Meijer C, Pou V, Borne BV. Health-seeking behaviors and self-care practices of Dominican women with lymphedema of the leg: implications for lymphedema management programs. Filaria J. 2006 Dec 22;5(1):13.

Burkot TR, Durrheim DN, Melrose W, Speare R, Ichimori K. The argument for integrating vector control with multiple drug administration campaigns to ensure elimination of lymphatic filariasis. Filaria J. 2006;5:10.

Mathieu E, Direny AN, de Rochars MB, Streit TG, Addiss D, Lammie PJ. Participation in three consecutive mass drug administrations in Leogane, Haiti. Trop Med Int Health. 2006 Jun;11(6):862-8.

Lammie PJ. The promise of wolbachia-targeted chemotherapy as a public health intervention for lymphatic filariasis and onchocerciasis. Clin Infect Dis. 2006 Apr 15;42(8):1090-2. Epub 2006 Mar 14.

de Rochars MB, Kanjilal S, Direny AN, Radday J, Lafontant JG, Mathieu E, et al. The Leogane, Haiti demonstration project: decreased microfilaremia and program costs after three years of mass drug administration. Am J Trop Med Hyg. 2005 Nov;73(5):888-94.

Dreyer G, Addiss D, Noroes J. Does longevity of adult Wuchereria bancrofti increase with decreasing intensity of parasite transmission? Insights from clinical observations. Trans R Soc Trop Med Hyg. 2005 Dec;99(12):883-92. Epub 2005 Sep 13. Review.

Beau de Rochars MV, Milord MD, St Jean Y, Desormeaux AM, Dorvil JJ, Lafontant JG, et al. Geographic distribution of lymphatic filariasis in Haiti. Am J Trop Med Hyg. 2004 Nov;71(5):598-601.

de Rochars MB, Direny AN, Roberts JM, Addiss DG, Radday J, Beach MJ, et al. Community-wide reduction in prevalence and intensity of intestinal helminths as a collateral benefit of lymphatic filariasis elimination programs. Am J Trop Med Hyg. 2004 Oct;71(4):466-70.

Mathieu E, Lammie PJ, Radday J, Beach MJ, Streit T, Wendt J, et al. Factors associated with participation in a campaign of mass treatment against lymphatic filariasis, in Leogane, Haiti. Ann Trop Med Parasitol. 2004 Oct;98(7):703-14.

Washington CH, Radday J, Streit TG, Boyd HA, Beach MJ, Addiss DG, et al. Spatial clustering of filarial transmission before and after a Mass Drug Administration in a setting of low infection prevalence. Filaria J. 2004 May 5;3(1):3.

Boyd HA, Waller LA, Flanders WD, Beach MJ, Sivilus JS, Lovince R, et al. Community- and individual-level determinants of Wuchereria bancrofti infection in Leogane Commune, Haiti. Am J Trop Med Hyg. 2004 Mar;70(3):266-72.

Cuenco KT, Halloran ME, Louis-Charles J, Lammie PJ. A family study of lymphedema of the leg in a lymphatic filariasis-endemic area. Am J Trop Med Hyg. 2004 Feb;70(2):180-4.

Cuenco KT, Halloran ME, Lammie PJ. Assessment of families for excess risk of lymphedema of the leg in a lymphatic filariasis-endemic area. Am J Trop Med Hyg. 2004 Feb;70(2):185-90.

Rheingans RD, Haddix AC, Messonnier ML, Meltzer M, Mayard G, Addiss DG. Willingness to pay for prevention and treatment of lymphatic filariasis in Leogane, Haiti. Filaria J. 2004 Jan 30;3(1):2.

Addiss DG, Rheingans R, Twum-Danso NA, Richards FO. A Framework for Decision-Making for Mass Distribution of Mectizan(R) in Areas Endemic for Loa loa. Filaria J. 2003 Oct 24;2 Suppl 1:S9.

Mathieu E, Deming M, Lammie PJ, McLaughlin SI, Beach MJ, Deodat DJ, et al. Comparison of methods for estimating drug coverage for filariasis elimination, Leogane Commune, Haiti. Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):501-5.

McLaughlin SI, Radday J, Michel MC, Addiss DG, Beach MJ, Lammie PJ, et al. Frequency, severity, and costs of adverse reactions following mass treatment for lymphatic filariasis using diethylcarbamazine and albendazole in Leogane, Haiti, 2000. Am J Trop Med Hyg. 2003 May;68(5):568-73.

Freeman AR, Lammie PJ, Houston R, LaPointe MD, Streit TG, Jooste PL, et al. A community-based trial for the control of lymphatic filariasis and iodine deficiency using salt fortified with diethylcarbamazine and iodine. Am J Trop Med Hyg. 2001 Dec;65(6):865-71.

Beach MJ, Streit TG, Houston R, May WA, Addiss DG, Lammie PJ. Short report: documentation of iodine deficiency in Haitian schoolchildren: implication for lymphatic filariasis elimination in Haiti. Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2):56-7.

Rawlins SC, Lammie P, Tiwari T, Pons P, Chadee DD, Oostburg BF, et al. Lymphatic filariasis in the Caribbean region: the opportunity for its elimination and certification. Rev Panam Salud Publica. 2000 May;7(5):319-24.

Seim AR, Dreyer G, Addiss DG. Controlling morbidity and interrupting transmission: twin pillars of lymphatic filariasis elimination. Rev Soc Bras Med Trop. 1999 May-Jun;32(3):325-8. Review.

Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg. 1999 Mar;60(3):479-86.

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Lammie PJ, Weil G, Noordin R, Kaliraj P, Steel C, Goodman D, et al. Recombinant antigen-based antibody assays for the diagnosis and surveillance of lymphatic filariasis - a multicenter trial. Filaria J. 2004 Sep 3;3(1):9.

Punkosdy GA, Addiss DG, Lammie PJ. Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis. Infect Immun. 2003 Sep;71(9):5104-14.

Goodman DS, Orelus JN, Roberts JM, Lammie PJ, Streit TG. PCR and Mosquito dissection as tools to monitor filarial infection levels following mass treatment. Filaria J. 2003 Jul 7;2(1):11.

Lammie PJ, Cuenco KT, Punkosdy GA. The pathogenesis of filarial lymphedema: is it the worm or is it the host? Ann NY Acad Sci. 2002 Dec;979:131-42; discussion 188-96. Review.

Williams SA, Laney SJ, Bierwert LA, Saunders LJ, Boakye DA, Fischer P, et al. Development and standardization of a rapid, PCR-based method for the detection of Wuchereria bancrofti in mosquitoes, for xenomonitoring the human prevalence of bancroftian filariasis. Ann Trop Med Parasitol. 2002 Dec;96 Suppl 2:S41-6.

Punkosdy GA, Dennis VA, Lasater BL, Tzertzinis G, Foster JM, Lammie PJ. Detection of serum IgG antibodies specific for Wolbachia surface protein in rhesus monkeys infected with Brugia malayi. J Infect Dis. 2001 Aug 1;184(3):385-9. Epub 2001 Jul 3.

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Page last modified: April 24, 2008
Page last reviewed: February 27, 2007
Content Source: Division of Parasitic Diseases (DPD)
National Center for Zoonotic, Vector-borne, and Enteric Diseases (ZVED)
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