TABLE 1: Prevalence of family history of cancer among female relatives of controls
in the Cancer and Steroid Hormone study (CASH), 1980-1982, N=4530
| Breast |
First-degree |
290 |
6.4 |
5.7, 7.1 |
|
Second-degree |
602 |
13.3 |
12.3, 14.3 |
|
None |
3593 |
79.3 |
78.1, 80.5 |
|
Unknown b |
45 |
1.0 |
0.7, 1.3 |
| Ovary |
First-degree |
50 |
1.1 |
0.8, 1.4 |
|
Second-degree |
65 |
1.4 |
1.1, 1.7 |
|
None |
4363 |
96.3 |
95.8, 96.8 |
|
Unknown b |
52 |
1.2 |
0.8, 1.4 |
| Endometrium |
First-degree |
158 |
3.5 |
3.0, 4.0 |
|
Second-degree |
119 |
2.6 |
2.1, 3.1 |
|
None |
4204 |
92.8 |
92.0, 93.6 |
|
Unknown b |
49 |
1.1 |
0.8, 1.4 |
| Cervix c |
First-degree |
96 |
2.1 |
1.7, 2.5 |
|
None |
4370 |
96.5 |
96.0, 97.0 |
|
Unknown b |
42 |
0.9 |
0.6, 1.2 |
| Colorectal c |
First-degree |
110 |
2.4 |
2.1, 2.9 |
|
None |
4279 |
94.5 |
93.8, 95.2 |
|
Unknown b |
48 |
1.1 |
0.8, 1.4 |
| Lung c |
First-degree |
69 |
1.5 |
1.2, 1.8 |
|
None |
4390 |
96.9 |
93.4, 97.4 |
|
Unknown b |
47 |
1.0 |
0.7, 1.3 |
| Thyroid c |
First-degree |
22 |
0.5 |
0.3, 0.7 |
|
None |
4455 |
98.3 |
97.9, 98.7 |
|
Unknown b |
49 |
1.1 |
0.8, 1.4 |
| Other c |
First-degree |
406 |
9.0 |
8.2, 9.8 |
|
None |
3778 |
83.4 |
82.3, 84.5 |
|
Unknown b |
33 |
0.7 |
0.5, 0.9 |
a May not total 100% due to incomplete information on second-degree relatives.
b Respondent did not know if her first-degree relatives had this cancer type.
c Second-degree prevalence not reported due to incomplete information on aunts.
TABLE 2: Prevalence of family history of cancer among female relatives by age of respondents,
Cancer and Steroid Hormone (CASH) study, 1980-1982, N=4262 a
| Breast |
1° |
42 |
4.3 |
3.0, 5.6 |
133 |
6.9 |
5.8, 8.0 |
112 |
8.3 *** |
6.8, 9.8 |
|
2 ° |
145 |
14.8 |
12.6, 17.0 |
261 |
13.5 |
12.0, 15.0 |
165 |
12.2 |
10.5, 13.9 |
|
None |
790 |
80.6 |
78.1, 83.1 |
1513 |
78.5 |
76.7, 80.3 |
1056 |
77.9 |
75.7, 80.1 |
|
Unk c |
3 |
0.3 |
0, 0.6 |
20 |
1.0 |
0.6, 1.4 |
22 |
1.6 ** |
0.9, 2.3 |
| Ovary |
1° |
9 |
0.9 |
0.3, 1.5 |
20 |
1.0 |
0.6, 1.4 |
17 |
1.3 |
0.7, 1.9 |
|
2 ° |
16 |
1.6 |
0.8, 2.4 |
29 |
1.5 |
1.0, 2.0 |
18 |
1.3 |
0.7, 1.9 |
|
None |
951 |
97.0 |
95.9, 98.1 |
1855 |
96.3 |
95.5, 97.1 |
1295 |
95.6 |
94.5, 96.7 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
23 |
1.2 |
0.7, 1.7 |
25 |
1.9 * |
1.2, 2.6 |
| Endometrium |
1° |
26 |
2.7 |
1.7, 3.7 |
77 |
4.0 |
3.1, 4.9 |
52 |
3.8 |
2.8, 4.8 |
|
2 ° |
28 |
2.9 |
1.8, 4.0 |
49 |
2.5 |
1.8, 3.2 |
35 |
2.6 |
1.8, 3.4 |
|
None |
922 |
94.1 |
92.6, 95.6 |
1782 |
92.5 |
91.3, 93.7 |
1242 |
91.7 |
96.2, 93.2 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
19 |
1.0 |
0.6, 1.4 |
26 |
1.9 ** |
1.2, 2.6 |
| Cervix d |
1° |
15 |
1.5 |
0.8, 2.2 |
47 |
2.4 |
1.7, 3.1 |
31 |
2.3 |
1.5, 3.1 |
|
None |
953 |
97.2 |
96.2, 98.2 |
1859 |
96.5 |
95.8, 97.2 |
1296 |
95.7 |
94.9, 96.5 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
15 |
0.8 |
0.4, 1.2 |
23 |
1.7 ** |
1.0, 2.4 |
| Colon d |
1° |
15 |
1.5 |
0.8, 2.2 |
49 |
2.5 |
1.8, 3.2 |
45 |
3.3 ** |
2.3, 4.3 |
|
None |
928 |
94.7 |
93.3, 96.1 |
1817 |
94.3 |
93.3, 95.3 |
1268 |
93.6 |
92.3, 94.9 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
17 |
0.9 |
0.5, 1.3 |
27 |
2.0 ** |
1.3, 2.7 |
| Lung d |
1° |
10 |
1.0 |
0.4, 1.6 |
34 |
1.8 |
1.2, 2.4 |
23 |
1.7 |
1.0, 2.4 |
|
None |
958 |
97.8 |
96.9, 98.7 |
1865 |
96.8 |
96.0, 97.6 |
1304 |
96.2 |
95.2, 97.2 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
18 |
0.9 |
0.5, 1.3 |
25 |
1.9 ** |
1.2, 2.6 |
| Thyroid d |
1° |
5 |
0.5 |
0.1, 0.9 |
11 |
0.6 |
0.3, 0.9 |
5 |
0.4 |
0, 0.7 |
|
None |
970 |
99.0 |
98.4, 99.6 |
1896 |
98.4 |
97.8, 99.0 |
1322 |
97.6 |
96.8, 98.4 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
18 |
0.9 |
0.5, 1.3 |
27 |
2.0 ** |
1.3, 2.7 |
| Other d |
1° |
54 |
5.5 |
4.1, 6.9 |
176 |
9.1 |
7.8, 10.4 |
161 |
11.9 |
10.2, 13.6 |
|
None |
822 |
83.9 |
83.5, 84.3 |
1618 |
84.0 |
82.4, 85.6 |
1108 |
81.8 |
79.7, 83.9 |
|
Unk c |
4 |
0.4 |
0, 0.8 |
12 |
0.6 |
0.3, 0.9 |
17 |
1.3 * |
0.7, 1.9 |
a Women aged 20-20 years were excluded as too few reported a positive family history to generate stable estimates.
b May not total 100% due to incomplete information on second-degree relatives.
c Respondent did not know if her first-degree relatives had this cancer type.
d Second-degree prevalence not reported due to incomplete information on aunts.
*?² trend: p<0.05; **?² , p<0.01 ; ***? ², p<0.001
TABLE 3: Age-adjusted prevalence of family history of cancer among female relatives by race of respondent, Cancer and Steroid Hormone study, 1980-1982a, N=4530
| Breast |
1° |
258 |
6.6 |
5.8, 7.4 |
22 |
4.7 |
2.8, 6.6 |
10 |
2.1 * |
0.4, 3.8 |
|
2° |
547 |
14.9 |
13.8, 16.0 |
40 |
7.8 ** |
5.4, 10.2 |
15 |
7.1 *** |
4.1, 10.1 |
|
None |
2941 |
81.3 |
80.1, 82.5 |
396 |
87.4 *** |
84.3, 90.4 |
256 |
91.0 *** |
87.7, 94.3 |
|
Unk b |
36 |
0.5 |
0.3, 0.7 |
4 |
0.7 |
0, 1.5 |
5 |
0.7 |
0, 1.7 |
| Endometrium |
1° |
130 |
2.4 |
1.9, 2.9 |
20 |
4.2 |
2.4, 6.0 |
8 |
1.4 |
0, 2.8 |
|
2° |
98 |
2.9 |
2.4, 3.4 |
12 |
2.8 |
1.3, 4.3 |
9 |
2.1 |
0.4, 3.8 |
|
None |
3513 |
95.0 |
94.3, 95.7 |
427 |
93.2 |
90.9, 95.5 |
264 |
96.4 |
94.3, 98.6 |
|
Unk b |
41 |
0.5 |
0.3, 0.7 |
3 |
0.6 |
0, 1.3 |
5 |
0.7 |
0, 1.7 |
a Age-adjusted to 1990 SEER U.S. standard population for mortality.
b Respondent did not know if her first-degree relatives had this cancer type.
* versus white women: p<0.05; ** p<0.001; *** p<0.0001.
TABLE 4: Prevalence of family history of breast cancer among first-degree female relatives of controls
from the Cancer and Steroid Hormone (CASH) study (1980-1982)
and the Women’s Interview Study on Health (WISH) (1990-1992),
Atlanta and Seattle
| Overall (%) |
877 |
5.9 |
4.3, 7.5 |
|
1544 |
6.2 |
5.0, 7.4 |
|
| Age-specific (%) |
|
|
|
|
|
|
|
|
| 20-29 years |
63 |
0 |
|
NC |
36 |
11.1 |
9.5, 12.7 |
2.06 |
| 30-39 years |
240 |
4.2 |
2.9, 5.5 |
1.00 b |
430 |
5.8 |
4.6, 7.0 |
1.00 b |
| 40-49 years |
343 |
7.3 |
5.6, 9.0 |
2.31 * |
818 |
5.8 |
4.6, 7.0 |
0.98 |
| 50-54 years |
231 |
7.4 |
5.7, 9.1 |
2.26 * |
260 c |
7.3 |
6.0, 8.6 |
1.22 |
| Race-specific (%) |
|
|
|
|
|
|
|
|
| White |
727 |
6.6 |
5.0, 8.2 |
1.00 b |
1186 |
6.7 |
5.5, 7.9 |
1.00 b |
| Black |
123 |
1.6 |
0.8, 2.4 |
0.24 * |
278 |
5.0 |
3.9, 6.1 |
0.72 |
| Other |
27 |
7.4 |
5.7, 9.1 |
1.22 |
80 |
1.3 |
0.8, 1.9 |
0.18 |
a Separate multivariate models for each study were adjusted for age as a continuous variable and race. Women aged 20-29 years were excluded from the CASH model.
b Referent group
c All women 50-54 years from the WISH study were from Atlanta.
* OR statistically significant.
NC – not calculated
|
|