TABLE 1: Distribution of families by the observed number of first degree relatives with breast
cancer and by family history score (FHS): Cancer Prevention Study II, United States, 1982-1
0 |
420,136 |
0 |
0 |
0 |
k=0.65 (SEH=.0015) |
1 |
0 |
10,979 |
0 |
0 |
z = 430 |
2 |
0 |
10,871 |
104 |
0 |
|
3 |
0 |
9,268 |
1,585 |
130 |
|
Total |
420,136 |
31,118 |
1,689 |
130 |
|
* All families with positive FHS were divided into three equal groups, I.e.,1 = low, first 33%;
2 = medium, second 33%; and 3 = high FHS, third 33%.
H SE, standard error.
TABLE 2: Family characteristics by different methods of classifying family history of breast cancer:
Cancer Prevention Study II, United States, 1982-1991
Observed cases |
|
|
|
|
|
|
|
0 |
420136 |
3.3 (1.3) |
60.4 (9.9) |
93.8 |
0.0 |
0.048 (.027) |
0.0 |
1 |
31118 |
3.6 (1.3) |
61.1 (9.1) |
96.4 |
1.0 |
0.049 (.030) |
5.0 (2.0) |
2 |
1689 |
4.5 (1.2) |
62.6 (8.0) |
97.3 |
2.0 |
0.063 (.030) |
8.6 (2.8) |
3+ |
130 |
5.5 (1.1) |
62.2 (7.7) |
97.7 |
3.0 |
0.073 (.034) |
12.5 (4.1) |
FHSI |
|
|
|
|
|
|
|
0 |
420136 |
3.3 (1.3) |
60.4 (9.9) |
93.8 |
0.0 |
0.048 (.027) |
0.0 |
1 |
10979 |
4.6 (1.2) |
66.4 (7.0) |
97.6 |
1.0 |
0.082 (.025) |
3.3 (0.5) |
2 |
10975 |
3.3 (1.0) |
61.4 (7.7) |
96.3 |
1.1 (0.1) |
0.042 (.011) |
4.8 (0.4) |
3 |
10983 |
2.9 (1.1) |
55.8 (9.1) |
95.5 |
1.2 (0.4) |
0.026 (.018) |
7.6 (2.2) |
All families |
453073 |
3.3 (1.3) |
60.5 (9.9) |
94.0 |
0.08 (0.28) |
0.049 (.027) |
0.38 (1.5) |
* The family includes mothers and sisters only.
H SD = Standard deviation; FHS, family history score.
I We divided all families with positive family history score (FHS) into three equal groups (1 = low, first 33%; 2 = medium, second 33%;
and 3 = high FHS, third 33%)
TABLE 3: Comparison of the effect of different family history definitions on the risk of fatal breast cancer:
Cancer Prevention Study II, United States, 1982-1991
Unadjusted |
|
|
|
|
|
|
|
|
|
|
< 40 |
4.9 |
2.0-11.8 |
I |
I |
I |
I |
I |
I |
5.1 |
2.1-12.4 |
40-49 |
2.3 |
1.6-3.4 |
0.99 |
0.26-4.2 |
0.75 |
0.11-5.4 |
1.7 |
1.3-2.8 |
3.3 |
2.2-4.9 |
50-59 |
1.8 |
1.4-2.4 |
1.06 |
0.25-4.2 |
1.4 |
0.80-2.3 |
1.9 |
1.3-2.8 |
1.9 |
1.3-3.0 |
>= 60 |
1.3 |
0.96-1.6 |
1.07 |
0.40-2.9 |
1.0 |
0.68-1.5 |
1.5 |
0.97-2.2 |
1.7 |
0.96-2.9 |
All age |
1.7 |
1.4-2.0 |
2.0 |
1.1-3.6 |
1.3 |
0.97-1.7 |
1.8 |
1.4-2.3 |
2.0 |
1.6-2.6 |
Fully adjusted ζ |
|
|
|
|
|
|
|
|
|
|
All age |
1.6 |
1.4-1.9 |
1.7 |
0.94-3.1 |
1.0 |
0.8-1.4 |
1.6 |
1.3-2.1 |
2.3 |
1.8-2.9 |
* FHS, family history score; CI, confidence interval.
H All families with positive FHS were divided into three equal groups, I.e., 1 = low, first 33%; 2 = medium, second 33%; and 3 = high FHS, third 33%.
I The relative hazard can not be calculated because there were no cases of breast cancer in the category.
ζ Estimates were adjusted for menopausal status; age at menarche; age when first living child was born; history of breast cysts; oral contraceptive
use; other estrogen use; body-mass index; diethystilbestrol (DES); education; religion; race; alcohol use; smoking status;
and among postmenopausal women, the age at which periods stopped.
TABLE 4: Summary of estimates from proportional hazard and logistic analysis by different family history classifications:
Cancer Prevention Study II, United States, 1982-1991
Observed breast cancer casesI |
1.49 |
1.30-1.73 |
1.50 |
1.30-1.73 |
0.033 |
0.085 |
0.73 |
FHSHI |
1.10 |
1.07-1.13 |
1.10 |
1.07-1.12 |
0.036 |
0.091 |
0.75 |
Observed breast cancer casesζ |
|
|
|
|
|
|
|
0 |
1.0 |
|
1.0 |
|
|
|
|
1 |
1.59 |
1.36-1.27 |
1.59 |
1.36-1.28 |
|
|
|
2+ |
1.71 |
0.94-3.09 |
1.72 |
0.95-3.10 |
0.035 |
0.087 |
0.73 |
FHSζ |
|
|
|
|
|
|
|
0 |
1.0 |
|
1.0 |
|
|
|
|
1 |
1.06 |
0.78-1.43 |
1.06 |
0.78-1.45 |
|
|
|
2 |
1.64 |
1.27-2.14 |
1.66 |
1.29-2.19 |
|
|
|
3 |
2.31 |
1.80-2.96 |
2.30 |
1.80-2.95 |
0.039 |
0.099 |
0.77 |
* Estimates were adjusted for menopausal status; age at menarche; age when first living child was born; history of breast cysts;
oral contraceptive use; other estrogen use; body-mass index; diethystilbestrol (DES); education; religion; race; alcohol use; smoking
status; and among postmenopausal women, the age at which periods stopped.
H CI, confidence interval; FHS, family history score.
I Observed breast cancer cases and FHS used as continuous variables.
ζ Observed breast cancer cases and FHS used as categorical variables. All families with positive FHS were divided into three equal
groups, i.e., 1 = low, first 33%; 2 = medium, second 33%; and 3 = high FHS, third 33%.
|
|