CDC's National Office of Public Health Genomics is looking for a nurse consultant. For more information about the position, click on the U.S. Department of Health and Human Services web site and enter the vacancy number (HHS-CDC-T2-2009-0188 (408KB) – for current employees or HHS-CDC-D2-2009-0085  (318KB) – for non-federal applicants). Application deadline: December 31, 2008, 11:59 p.m. (EST)
	The American Public Health Association (APHA) Genomics Forum makes a call for genomics-related abstracts (576KB) for the 137th APHA Annual Meeting & Expo to be held November 7-11, 2009, in Philadelphia, Pennsylvania. Deadline: February 10, 2009. For more information, contact Dean Hosgood hosgoodd@mail.nih.gov.
	The University of Michigan Center for Public Health and Community Genomics releases study findings on Genomics and Public Health Practice: Lessons from State Pilot Projects. (176KB)

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
In lung cancer, silencing one crucial gene disrupts normal functioning of genome, Medical News Today. December 31	Drinkers with the ADH1C gene at greater risk of colorectal cancer, News-Medical.Net, December 22
Prostate cancer screening has pros and cons, nj.com, December 30	Scientists find gene that is a powerful predictor of colon cancer metastasis, News-Medical.Net, December 22
Many studies needed to tie genes to cancer: study, Reuters Health, December 30	Baby girl free of breast cancer gene due to be born soon, Medical News Today, December 21
Targeted nanoparticles deliver therapeutic DNA to cancer cells, News-Medical.Net, December 29	Researchers identify gene linked to inherited form of fatal lung disease, News-Medical.Net, December 21
The Von Hippel-Lindau Gene: Turning discovery into therapy, Medical News Today, December 25	Researchers create 'suped up' gene that forces cancer cells to self destruct, News-Medical.Net, December 18
Breast cancer genome shows evolution, instability of cancer, Science Daily, December 24

Public Awareness and Use of Direct-to-Consumer Genetic Tests: Results From 3 State Population-Based Surveys, 2006 Goddard KA, et al. Am J Public Health 2008 Dec

Cohort studies and the genetics of complex disease
Manolio TA
Nat Genet 2009 Jan;41(1):5-6

All we need is GWAS: Genome-Wide Association Studies in Type 2 Diabetes Mellitus  presented on the 2008 EASD Meeting in Rome
Klupa T & Malecki MT
Rev Diabet Stud 2008 Fall;5(3):175-9

SNPHarvester: a filtering-based approach for detecting epistatic interactions in  genome-wide association studies
Yang C, et al.
Bioinformatics 2008 Dec

Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not  help at all
Delgado-Escueta AV & Bourgeois BF
Epilepsia 2008 Dec;49 Suppl 9:13-24

Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova A, et al.
Nat Rev Genet 2009 Jan;10(1):43-55

Breast cancer susceptibility: current knowledge and implications for genetic counseling
Ripperger T, et al.
Eur J Hum Genet 2008 Dec

Legal update: living with the Genetic Information Nondiscrimination Act
Erwin C
Genet Med 2008 Dec;10(12):869-73

Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders
Moskowitz SM, et al.
Genet Med 2008 Dec;10(12):851-68

Pharmacogenetics in breast cancer therapy
Tan SH, et al.
Clin Cancer Res 2008 Dec;14(24):8027-41

Genetic susceptibility loci for breast cancer by estrogen receptor status
Garcia-Closas M & Chanock S
Clin Cancer Res 2008 Dec;14(24):8000-9

The genetic basis for type 1 diabetes
Mehers KL & Gillespie KM
Br Med Bull 2008;88(1):115-29

Asking the Right Questions: Views on Genetic Variation Research Among Black and White Research Participants
Bussey-Jones J, et al.
J Gen Intern Med 2008 Dec

Pharmacokinetics and pharmacogenomics in breast cancer chemotherapy
Marsh S & Liu G
Adv Drug Deliv Rev 2008 Dec

Pharmacogenetics in acute lymphoblastic leukemia
Cheok MH, et al.
Semin Hematol 2009 Jan;46(1):39-51

MedRefSNP: a database of medically investigated SNPs
Rhee H & Lee JS
Hum Mutat 2008 Dec

Prostate cancer genomics: towards a new understanding
Witte JS
Nat Rev Genet 2008 Dec

Oophorectomy for breast cancer prevention in women with BRCA1 or BRCA2 mutations
Metcalfe KA
Womens Health (Lond Engl) 2009 Jan;5(1):63-8

Clinical geneticists in birth defects surveillance and epidemiology research programs: Past, present and future roles
Lin AE, et al.
Birth Defects Res A Clin Mol Teratol 2008 Dec

Relation of familial patterns of coronary heart disease, stroke, and diabetes to  subclinical atherosclerosis: the multi-ethnic study of atherosclerosis
Scheuner MT, et al.
Genet Med 2008 Dec;10(12):879-87

Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation
Metcalfe KA, et al.
Br J Cancer 2008 Dec

Patient interest in recording family histories of cancer via the Internet
Simon C, et al.
Genet Med 2008 Dec;10(12):895-902

Familial risks for amyotrophic lateral sclerosis and autoimmune diseases
Hemminki K, et al.
Neurogenetics 2008 Dec

Serum adiponectin is associated with family history of diabetes independently of  obesity and insulin resistance in healthy Korean men and women
Sull JW, et al.
Eur J Endocrinol 2009 Jan;160(1):39-43

 

Selecting a BRCA risk assessment model for use in a familial cancer clinic
Panchal S, et al.
BMC Med Genet 2008 Dec;9(1):116

Clinical Utility of Genetic Tests for Inherited Hypertrophic and Dilated Cardiomyopathies
Colombo MG, et al.
Cardiovasc Ultrasound 2008 Dec;6(1):62

The influence of acculturation and breast cancer-specific distress on perceived barriers to genetic testing for breast cancer among women of African descent
Sussner KM, et al.
Psychooncology 2008 Dec

Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda
Meiser B, et al.
Breast Cancer Res 2008 Nov;10(6):216

The impact of direct-to-consumer marketing of cancer genetic testing on women according to their genetic risk
Lowery JT, et al.
Genet Med 2008 Dec;10(12):888-94

Molecular diagnosis of Fragile X syndrome
Sofocleous C, et al.
Expert Rev Mol Diagn 2009 Jan;9(1):23-30

Hereditary breast and ovarian cancer syndrome : the impact of race on uptake of genetic counseling and testing
Simon MS & Petrucelli N
Methods Mol Biol 2009;471:487-500

Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts
Muglia P, et al.
Mol Psychiatry 2008 Dec

New sequence variants associated with bone mineral density
Styrkarsdottir U, et al.
Nat Genet 2008 Dec

A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume
Meisinger C, et al.
Am J Hum Genet 2008 Dec

Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples
Johnson C, et al.
BMC Med Genet 2008 Dec;9(1):113

Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study
Dalmasso C, et al.
PLoS ONE 2008;3(12):e3907

 

Cytochrome P-450 Polymorphisms and Response to Clopidogrel
Mega JL, et al.
N Engl J Med 2008 Dec

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events
Simon T, et al.
N Engl J Med 2008 Dec

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