The original PRS efficacy review, including studies published between 1988 and 1996, identified 24 evidence-based behavioral interventions. These interventions were summarized in the Compendium of HIV Prevention Interventions with Evidence of Effectiveness (CDC, 1999) [1].  Refer to Review findings for more details about the original and updated findings. This original review was based on the Compendium criteria. Since then PRS strengthened its criteria for identifying evidence-based, individual- and group-level behavioral interventions. More details about these criteria can be found at Efficacy criteria

Half of the 24 HIV behavioral interventions that were identified in the original Compendium of HIV Prevention Interventions with Evidence of Effectiveness using the less rigorous Compendium criteria meet either the current best-evidence criteria or the current promising-evidence criteria. There are 12 of the original 24 Compendium interventions that either (1) do not meet the best-evidence and promising-evidence criteria; or (2) have not been evaluated because they are community-level interventions. Eight Compendium interventions are individual- (ILIs) or group-level (GLIs) interventions that do not meet the current criteria for best- or promising-evidence and are listed below, most commonly due to low retention rates or small analytical sample sizes. Most of these ILIs/GLIs fit in Tier III of the Tiers of Evidence Framework.

Four Compendium interventions listed below are community-level interventions (CLIs), which have not yet been evaluated. Because most CLIs have study and design characteristics that do not lend themselves to evaluation with the ILIs and GLIs efficacy criteria, PRS, in consultation with expert methodologists and interventionists, is developing new efficacy criteria for community-level interventions. CDC expects that the review of CLIs will be completed by Spring, 2008.

CDC-funded programs using DEBIs that are among the 4 CLIs not yet reviewed or among the 8 ILIs/GLIs not meeting the best-evidence or promising-evidence criteria, can continue implementing these interventions for the time being. Agencies that are planning to implement a new ILI or GLI are encouraged to select an intervention from among the best-evidence or promising-evidence ILI and GLI interventions.

KEY: HS=Heterosexual; HIV+=HIV-positive; HR=High-risk; MSM=Men who have sex with men; DU=Drug users; M=Males; F=Females; W=White; AA=African American; AI=American Indian; H=Hispanic; API=Asian/Pacific Islander; O=Other racial/ethnic group; GLI=group-level intervention; ILI=individual-level intervention

Individual-level and group-level interventions meeting previous Compendium criteria: 

• Behavioral Self-Management and Assertion Skills
  Risk category: MSM
  Sex: 100% M
  Race: 87% W, 13% AA or H
  Delivery Unit: GLI

• Cognitive-Behavioral Skills Training Group
  Risk category: HS Adult
  Sex: 100% F
  Race: 87% AA, 6% W, 4% AI, 3% H
  Delivery Unit: GLI

• Condom Skills Education
  Risk category: HS Adult
  Sex: 69% M, 41% F
  Race: 76% AA, 15% H, 9% O
  Delivery Unit: GLI

• Enhanced AIDS Education
  Risk category: DU
  Sex: 67% M, 33% F
  Race: 81% W, 19% O
  Delivery Unit: ILI , GLI

• Reducing AIDS Risk Activity
  Risk category: HS Adult
  Sex: 100% F
  Race: 57% AA, 40% W, 3% O
  Delivery Unit: GLI

• SISTA
  Risk category: HS Adult
  Sex: 100% F
  Race: 100% AA
  Delivery Unit: GLI

• Skill Building
  Risk category: DU
  Sex: 100% F
  Race: 64% H, 36% AA
  Delivery Unit: GLI

• Small-group Lecture Plus Skill Training
  Risk category: MSM
  Sex: 100% M
  Race: 95% W, 2% AA, 1% API, 1% H, 1% O
  Delivery Unit: ILI , GLI

Community-Level Interventions:

• Community PROMISE
  Risk category: DU, HR Youth, HS Adult, MSM
  Sex: 45% M, 55% F
  Race: 54% AA, 22% W, 19% H, 5% O
  Delivery Unit: CLI, ILI

• Mpowerment
  Risk category: MSM
  Sex: 100% M
  Race: 81% W, 7% API, 6% H, 4% AA, 2% O
  Delivery Unit: CLI, GLI, ILI

• POL
  Risk category: MSM
  Sex: 100% M
  Race: 86% W, 14% AA or H
  Delivery Unit: CLI, GLI, ILI

• RAPP
  Risk category: HS Adult
  Sex: 100% F
  Race: 73% AA, 27% O
  Delivery Unit: CLI, GLI, ILI

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